Results 211 to 220 of about 20,424,840 (239)

Lactiplantibacillus Plantarum GUANKE Alleviates Allergic Asthma by Restricting Monocyte‐to‐DC Differentiation Via Microbiota‐Associated IAA

Advanced Science, EarlyView.
Lactiplantibacillus plantarum GUANKE remodels the indigenous gut microbiota and is associated with microbiota‐dependent restoration of circulating IAA. IAA treatment attenuates JAK3‐STAT3 and Jag1‐Notch4‐Hey1 signaling and reduces CX3CR1+Ly6C− monocytic precursor generation and pulmonary CD11b+ DC accumulation, together with reduced Th2 inflammation ...
Yujia He, Jielan Mi, Zhiping Zhao, Xiao Zhang, Zhihan Yang, Kun Yue, Yuanming Huang, Liqiong Song, Xiaoting Wen, Jianguo Xu, Zhihong Ren   +10 more
wiley   +1 more source

Rapid Sterilization of Clinical Apheresis Blood Products Using Ultra-High Dose Rate Radiation. [PDF]

Int J Mol Sci
Melemenidis S, Nguyen KD, Baraceros-Pineda R, Barclay CK, Bautista J, Lau HD, Ashraf MR, Manjappa R, Dutt S, Soto LA, Katila N, Lau B, Viswanathan V, Yu AS, Surucu M, Skinner LB, Engleman EG, Loo BW, Pham TD.   +18 more
europepmc   +1 more source

Loss of E3 Ubiquitin Ligase RINES via CpG Methylation Relieves Suppression of STAT3 and MYC, Facilitating Multiple Tumorigeneses

Advanced Science, EarlyView.
Dysregulated protein modifications drive tumorigenesis. RINES, an E3 ubiquitin ligase, represses tumor cell proliferation and metastasis by facilitating RING domain‐dependent, ubiquitin–proteasome‐mediated degradation of STAT3 and MYC, which consequently restrains cancer stemness and oncogenic progression.
Lili Li, Ka Man Ng, Xingsheng Shu, Xiaoxue Chai, Kai Yau Wong, Gopesh Srivastava, Anthony T.C. Chan, Wai Yee Chan, Qian Tao   +8 more
wiley   +1 more source

Impact of Ultra-High-Dose-Rate Irradiation on DNA: Single-Strand Breaks and Base Damage. [PDF]

Int J Mol Sci
Wang Y, Zhang Y, Huang C, Fu Q, Huang T.
europepmc   +1 more source

Biofilm‐Binding Phages Enhance Biofilm Eradication by Synergistic Photothermal and Photodynamic Therapy

Advanced Science, EarlyView.
Engineered phage‐based trifunctional nanofibers are developed for synergistic biofilm eradication. Biofilm‐binding phages, armed with AuNPs and TCPP, serve as both warheads and scaffolds, endowing the phototherapy agents with biofilm‐anchoring ability. Upon light irradiation, AuNPs induce photothermal therapy, while TCPP generates 1O2 for photodynamic ...
Ying Cao, Tao Yang, Rui Wang, Hui‐Da Li, Xiao‐Yu Zhang, Feng Cheng, Ying Liu, Jian‐Hua Wang, Ting Yang, Chuanbin Mao   +9 more
wiley   +1 more source

An Activity‐Reinforced P‐Modified Single‐Atom Cu Nanozyme Potentiates IDO Blockade‐Induced Tumor Radiotherapy

Advanced Science, EarlyView.
A phosphorus‐modified single‐atom copper nanozyme delivering the IDO1 inhibitor 1‐methyl‐tryptophan enhances breast cancer radioimmunotherapy by simultaneously relieving hypoxia and inducing immunogenic cell death through dual enzyme activities while blocking tryptophan metabolism to suppress regulatory T cell function.
Wei Zhao, Songliu Hu, Zhanggui Wang, Liqun Wang, Liming Zhang, Qi Li, Hua Tang, Yang Zhong, Zhongxian Zhang, Kelong Fan, Shipeng Ning, Xiyun Yan   +11 more
wiley   +1 more source

FLASH Radiotherapy is faster than a heartbeat: A compartmental model to illustrate the interplay between tissue oxygen perfusion and ultra-high dose rate effects

Ballesteros-Zebadua P, Jansen J, Grilj V, Franco-Perez J, Vozenin M, Abolfath R.   +5 more
europepmc   +1 more source

Investigating the Influence of Conventional vs. Ultra-High Dose Rate Proton Irradiation Under Normoxic or Hypoxic Conditions on Multiple Developmental Endpoints in Zebrafish Embryos. [PDF]

Cancers (Basel)
Faggian A, Pucci G, Verroi E, Fasolini A, Lorentini S, Citter S, Mione MC, Calvaruso M, Russo G, Scifoni E, Forte GI, Tommasino F, Bisio A.   +12 more
europepmc   +1 more source

A safety study of ultra-high dose rate FLASH radiotherapy in the treatment of superficial skin tumors: study protocol of a phase I trial (ChiCTR2400080935). [PDF]

Precis Radiat Oncol
Yang C, Luo H, Leijie M, Mao R, Lei H, Zhang Y, Xu M, Wang Y, Wu M, Liu H, Chen P, Ge H.   +11 more
europepmc   +1 more source