Results 51 to 60 of about 20,424,840 (239)

High Dose-Rate Versus Low Dose-Rate Brachytherapy for Lip Cancer

, 2012
To analyze the outcome after low-dose-rate (LDR) or high-dose-rate (HDR) brachytherapy for lip ...
Jens O. Brömme, Daniel M. Aebersold, Geretschläger, Andreas, Pica, Alessia, Bernhard Isaak, Beat Bojaxhiu, Brömme, Jens O, Aebersold, Daniel M, Ghadjar, Pirus, Simcock, Mathew, Isaak, Bernhard, Gut, Philipp, Wolfensberger, Patrick, Dario Terribilini, Bojaxhiu, Beat, Terribilini, Dario, Philipp Gut, Behrensmeier, Frank, Mathew Simcock, Alessia Pica, Patrick Wolfensberger, Pirus Ghadjar, Frank Behrensmeier, Andreas Geretschläger, Terribilini D, Aebersold DM, Gut P, Isaak B, Brömme JO, Brömme, Jens, Pica A, Behrensmeier F, Bojaxhiu B, Aebersold, Daniel Matthias, Geretschläger A, Wolfensberger P, Wolfensberger, Patrick Rudolf, Simcock M, Ghadjar P   +38 more
core   +1 more source

L‐aspartate oxidase provides new insights into fumarate reduction in anaerobic darkness in Synechocystis sp. PCC6803

FEBS Letters, EarlyView.
Synechocystis strains deficient in succinate dehydrogenase (SDH) secrete more succinate than the WT under dark anaerobic conditions, supporting that SDH then primarily acts as SDH, not as a fumarate reductase. L‐aspartate oxidase (Laspo) from Synechocystis is functional under anaerobic conditions, reducing fumarate to succinate.
Kateryna Kukil, Jeffrey A. Hawkes, Cecilia Blikstad, Pia Lindberg   +3 more
wiley   +1 more source

Modeling for predicting survival fraction of cells after ultra-high dose rate irradiation

, 2023
Objective. FLASH radiotherapy (FLASH-RT) with ultra-high dose rate (UHDR) irradiation (i.e. > 40 Gy s(-1)) spares the function of normal tissues while preserving antitumor efficacy, known as the FLASH effect.
Fukunaga, Hisanori, Matsuya, Yusuke, Kusumoto, Tamon, Shiraishi, Yuta   +3 more
core   +1 more source

Establishing Linearity of the MOSkin Detector for Ultra-High Dose-per-Pulse, Very-High-Energy Electron Radiotherapy Using Dose-Rate-Corrected EBT-XD Film

Applied Sciences
Very-high-energy electrons, coupled with ultra-high dose rates, are being explored for their potential use in radiotherapy to treat deep-seated tumours.
James Cayley, Elette Engels, Tessa Charles, Paul Bennetto, Matthew Cameron, Joel Poder, Daniel Hausermann, Jason Paino, Duncan Butler, Dean Cutajar, Marco Petasecca, Anatoly Rosenfeld, Yaw-Ren Eugene Tan, Michael Lerch   +13 more
doaj   +1 more source

Smaller is better: nanobodies meet NMR

FEBS Letters, EarlyView.
Nanobodies are single‐domain antigen‐binding fragments derived from camelid heavy chain antibodies. Their small size, high stability, and exceptional specificity make nanobodies uniquely useful probes for NMR studies of protein dynamics, transient conformational states, and protein–protein interactions.
Oleg Y. Dmitriev
wiley   +1 more source

Ultra-high dose rate effect on circulating immune cells: A potential mechanism for FLASH effect?

, 2020
Purpose “FLASH” radiotherapy (RT) is a potential paradigm-changing RT technology with marked tumor killing and normal tissue sparing. However, the mechanism of the FLASH effect is not well understood.
Kong, FMS, Gu, A, Wang, W, Machtay, M, Oleinick, NL, Jin, JY   +5 more
core   +1 more source

Instantaneous dose rate as a crucial factor in reducing mortality and normal tissue toxicities in murine total-body irradiation: a comparative study of dose rate combinations

Molecular Medicine
Purpose The ultra-high dose rate (UHDR) radiation shows promise in eradicating tumors while reducing normal tissue toxicities. However, the biological outcomes of UHDR are influenced by various factors, particularly the mean dose rate and instantaneous ...
Hongyu Zhu, Shihua Liu, Jiaqi Qiu, Ankang Hu, Wanyi Zhou, Jian Wang, Weihang Gu, Yinuo Zhu, Hao Zha, Rong Xiang, Junli Li, Rui Qiu, Chong Zhao, Peng Huang, Xiaowu Deng   +14 more
doaj   +1 more source

Comparison of intratumor and local immune response between MV X-ray FLASH and conventional radiotherapies

Clinical and Translational Radiation Oncology, 2023
Background/Purpose: Investigating the antitumor effect and intratumor as well as local immune response in breast cancer-bearing mice after MV X-ray ultra-high dose rate radiotherapy (FLASH-RT) and conventional dose rate radiotherapy (CONV-RT).
Hongyu Zhu, Dehuan Xie, Ying Wang, Runda Huang, Xi Chen, Yiwei Yang, Bin Wang, Yinglin Peng, Jianxin Wang, Dexin Xiao, Dai Wu, Chao-Nan Qian, Xiaowu Deng   +12 more
doaj   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Effects of ultra-high dose rate radiotherapy with different fractions and dose rate on acute and chronic lung injury in mice

Heliyon
Ultra-high dose rate radiotherapy (FLASH radiation) can naturally render normal tissues around the tumor tissue resistant to radiotherapy. In contrast, the tumor tissue remains sensitive to radiation under the same conditions.
Feng Gao, Binwei Lin, Yiwei Yang, Dexin Xiao, Zheng Zhou, Yu Zhang, Gang Feng, Jie Li, Dai Wu, Xiaobo Du, Qiuling Shi   +10 more
doaj   +1 more source