Results 61 to 70 of about 20,424,840 (239)

Cancer‐associated mutations in endometriosis reframe a benign disease through molecular oncology

Molecular Oncology, EarlyView.
This review aims to comprehensively analyse cancer‐associated somatic mutations (CAMs) present in endometriotic lesions, emphasizing their biological roles, spatial distribution and implications for translational applications in medicine. By contextualizing a benign state within a genomic framework, this analysis seeks to establish its value as a ...
Clarissa Mujacic, Maria Concetta Vitale, Rita Siino, Emilia Di Giovanni, Carla Ferrante Bannera, Enrico Di Marco, Andrea Gottardo, Tancredi Didier Bazan Russo, Nadia Barraco, Alessandro Perez, Valerio Gristina, Antonio Galvano, Giuseppe Badalamenti, Antonio Russo, Viviana Bazan, Lorena Incorvaia   +15 more
wiley   +1 more source

Development of Ultra-High Dose Rate (FLASH) Particle Therapy [PDF]

, 2021
Research efforts in FLASH radiotherapy have increased at an accelerated pace recently. FLASH radiotherapy involves ultra-high dose rates and has shown to reduce toxicity to normal tissue while maintaining tumor response in pre-clinical studies when ...
Kim, Michele M., Dokic, Ivana, Ramos-Mendez, Jose, Dong, Lei, Schuemann, Jan, Petersson, Kristoffer, Darafsheh, Arash, Zhao, Tianyu, Lundh, Olle, Kim, Michele M, Ramos-Mendez, Jose,, Darafsheh, Arash,, Dokic, Ivana,, Petersson, Kristoffer,, Schuemann, Jan,, Kim, Michele M.,, Zhao, Tianyu,, Lundh, Olle,, Dong, Lei,, Lund University., Tianyu Zhao, Ivana Dokic, Arash Darafsheh, Kristoffer Petersson, Olle Lundh, Jose Ramos-Mendez, Jan Schuemann, Lei Dong, Michele M. Kim   +28 more
core   +1 more source

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

Enabling ultra-high dose rate radiotherapy through hybrid lightweight rotary anode design

Materials & Design
Compact X-ray sources for spatially fractionated and ultra-high-dose-rate radiotherapy are limited by the extreme thermal and mechanical loads imposed on conventional rotary anodes.
Wilfried Behr, Dirk Federmann, Sonja Groß-Barsnick, Thomas Koppitz, Andre Janes, Anne Vollmers, Torsten Ortmanns, Debora Wanhoff, Thomas Töpfer, Guido Offermanns, Michael Butzek, Ghaleb Natour, Anton Dimroth   +12 more
doaj   +1 more source

Cancer Cells Can Exhibit a Sparing FLASH Effect at Low Doses Under Normoxic In Vitro-Conditions

Frontiers in Oncology, 2021
BackgroundIrradiation with ultra-high dose rate (FLASH) has been shown to spare normal tissue without hampering tumor control in several in vivo studies. Few cell lines have been investigated in vitro, and previous results are inconsistent. Assuming that
Gabriel Adrian, Gabriel Adrian, Elise Konradsson, Sarah Beyer, Anders Wittrup, Anders Wittrup, Anders Wittrup, Karl T. Butterworth, Stephen J. McMahon, Mihaela Ghita, Kristoffer Petersson, Kristoffer Petersson, Crister Ceberg   +12 more
doaj   +1 more source

Gut microbiota alterations in patients with non‐small‐cell lung cancer undergoing chemoradiotherapy

Molecular Oncology, EarlyView.
We investigated the impact of concurrent chemoradiotherapy (CRT) on the gut microbiota in patients with locally advanced non‐small‐cell lung cancer. Overall gut microbiota composition remained largely stable throughout CRT while antibiotic exposure may influence microbial diversity.
Hanne Marte Nymoen, Zhi Zhao, Henrik Horndalsveen, Maria Moksnes Bjaanæs, Bjørn Henning Grønberg, Tarje Halvorsen, Tesfaye Madebo, Marianne Aanerud, Jussi Koivunen, Kersti Oselin, Saulius Cicenas, Nina Helbekkmo, Jarkko Ahvonen, Maria Silvoniemi, Tine Norman Alver, Tonje Dalen, Åsa Kristina Öjlert, Saima Jamil Farooqi, Åslaug Helland, Vilde Drageset Haakensen   +19 more
wiley   +1 more source

SU-GG-T-487: Lack of Dose Rate Effect with Ultra-High Dose Rate Irradiation of Normal Tissue Fibroblasts and RT112 Tumour Cells

, 2010
Purpose: Radiation biology studies have previously investigated the effects of dose rate on in vitro clonogenic survival in numerous cell lines. The effect on cells from ultra‐high dose rates (>1Gy/sec, have not been reported.
Jeynes, C., Kirkby, K.; id_orcid, J Stancanello, Burnet, N., R Jena, S Duane, Jena, R., J Peacock, Peacock, J., N Burnet, Stancanello, J., Duane, S., C Thomas, K Kirkby, Thomas, C., C Jeynes   +15 more
core   +1 more source

Extracellular vesicle lipidomics liquid biopsy reveals systemic and tumor microenvironment metabolic reprogramming in ovarian cancer

Molecular Oncology, EarlyView.
Extracellular vesicle (EV) lipidomic profiling of plasma and ascites from patients with high‐grade serous ovarian cancer and of ovarian cancer cell lines reveals enrichment of triglycerides (TGs), diacylglycerols (DGs), phosphatidylcholine (PCs), sphingomyelins (SMs), reflecting tumor metabolic reprogramming.
Shikha Rani, Dominic Guanzon, Andrew Lai, Katherin Scholz‐Romero, Sarah Reed, Edita Ritmejeryte, Rohan Lourie, Naven Chetty, Kaltin Ferguson, Carlos Salomon   +9 more
wiley   +1 more source

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source

Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer

Molecular Oncology, EarlyView.
Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba, Mark Shacker, Timothy P. Fleming, Michael A. Smith, Ross M. Bremner, Narendra V. Sankpal   +5 more
wiley   +1 more source