Results 211 to 220 of about 31,798 (239)
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The burgeoning family of unconventional T cells
Nature Immunology, 2015While most studies of T lymphocytes have focused on T cells reactive to complexes of peptide and major histocompatibility complex (MHC) proteins, many other types of T cells do not fit this paradigm. These include CD1-restricted T cells, MR1-restricted mucosal associated invariant T cells (MAIT cells), MHC class Ib-reactive T cells, and γδ T cells ...
Jamie Rossjohn +2 more
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The role of unconventional T cells in maintaining tissue homeostasis
Seminars in Immunology, 2022Jonathan Melamed +1 more
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2010
1 Defining Unconventional T Cells 2 Subtypes of Unconventional T Cells: γδ T Cells 3 Subtypes of Unconventional T Cells: αβ T Cells Keywords: unconventional T cells; defining unconventional T cells; ‘professional’ antigen-presenting cells (APC); TCR gene cDNA (complementary DNA); murine dendritic epidermal T cells (DETC ...
Adrian Hayday, Carrie Steele
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1 Defining Unconventional T Cells 2 Subtypes of Unconventional T Cells: γδ T Cells 3 Subtypes of Unconventional T Cells: αβ T Cells Keywords: unconventional T cells; defining unconventional T cells; ‘professional’ antigen-presenting cells (APC); TCR gene cDNA (complementary DNA); murine dendritic epidermal T cells (DETC ...
Adrian Hayday, Carrie Steele
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The clinical landscape of CAR-engineered unconventional T cells
Trends in CancerUnconventional T cells, such as invariant natural killer T (iNKT), γδ T, and mucosal-associated invariant T (MAIT) cells, play a pivotal role in bridging innate and adaptive immunity. Their capacity for rapid tumor targeting and effective modulation of the tumor microenvironment (TME) makes them promising candidates for cancer immunotherapy.
Yan-Ruide Li, Yichen Zhu
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Unconventional recognition of peptides by T cells and the implications for autoimmunity
Nature Reviews Immunology, 2012The interaction of antigen-presenting cells with free peptides or a denatured protein can give rise to peptide-MHC class II complexes that are distinct from those generated after the processing of the whole protein. Such atypical peptide-MHC complexes can be recognized by unconventional 'type B' T cells that are not a component of the normal immune ...
Emil R. Unanue
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Phenotypical and Functional Characterization of Cytotoxic Unconventional T-Cells
2021During the last two decades, the immunology field has been focused on the study of conventional T-cells, leading to important advances in identification of specific subsets involved in promoting and suppressing immune response in patients with cancer, autoimmune disease or transplanted patients.
Gigante M., Ranieri E.
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Landscape of unconventional γδ T cell subsets in cancer
Molecular Biology ReportsT cells are broadly categorized into two groups, namely conventional and unconventional T cells. Conventional T cells are the most prevalent and well-studied subset of T cells. On the other hand, unconventional T cells exhibit diverse functions shared between innate and adaptive immune cells.
Parviz, Azimnasab-Sorkhabi +3 more
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Activation and Function of Unconventional T Cells
2018Efferent innate immune responses include the function of unconventional T cells with partial innate properties. While most studies of T lymphocytes have focused on T cells involved in adaptive immune responses by reacting to complexes of peptide and major histocompatibility complex proteins, many other types of T cells do not match this paradigm.
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Breaking the mold: Unconventional T cells in cancer therapy
Cancer CellUnconventional T cells, including invariant natural killer T (iNKT) cells, gamma delta (γδ) T cells, and mucosal-associated invariant T (MAIT) cells, play important roles in both innate and adaptive immunity. These cells respond to tumors rapidly and influence the tumor microenvironment (TME).
Yan-Ruide, Li +4 more
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The unconventional role of LTαβ in T cell differentiation
Trends in Immunology, 2007Lymphotoxin (LT)αβ, a member of the tumor necrosis factor cytokine superfamily, and its receptor, the LTβ receptor (LTβR), have a well defined role in secondary lymphoid organogenesis but an unexpected function in T cell differentiation. Although earlier studies indicated that conventional T cell subsets were normal in mice deficient in the LTβR ...
Dirk Elewaut, Carl F. Ware
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