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The duplexity of unconventional T cells in cancer [PDF]
International Journal of Biochemistry and Cell Biology, 2022 Unconventional T cells and their involvement in cancer are understudied in comparison to conventional T cells, but recent findings indicate that these cells play important roles in both cancer progression and inhibition. Here, we briefly review the dichotomous role of three unconventional T cell lineages: γδ T cells, MAIT cells and NKT cells.
Robert Wiesheu, Seth B. Coffelt
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Developmental & Comparative Immunology, 2022
Pigs are important domestic livestock and a comprehensive understanding of their immune system is critical to improve swine vaccine efficacy. Pig models represent an excellent animal model for immunological studies because of their anatomical and physiological similarities to humans.
Miaomiao Wu +4 more
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Pigs are important domestic livestock and a comprehensive understanding of their immune system is critical to improve swine vaccine efficacy. Pig models represent an excellent animal model for immunological studies because of their anatomical and physiological similarities to humans.
Miaomiao Wu +4 more
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The burgeoning family of unconventional T cells
Nature Immunology, 2015While most studies of T lymphocytes have focused on T cells reactive to complexes of peptide and major histocompatibility complex (MHC) proteins, many other types of T cells do not fit this paradigm. These include CD1-restricted T cells, MR1-restricted mucosal associated invariant T cells (MAIT cells), MHC class Ib-reactive T cells, and γδ T cells ...
Jamie Rossjohn +2 more
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2010
1 Defining Unconventional T Cells 2 Subtypes of Unconventional T Cells: γδ T Cells 3 Subtypes of Unconventional T Cells: αβ T Cells Keywords: unconventional T cells; defining unconventional T cells; ‘professional’ antigen-presenting cells (APC); TCR gene cDNA (complementary DNA); murine dendritic epidermal T cells (DETC ...
Adrian Hayday, Carrie Steele
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1 Defining Unconventional T Cells 2 Subtypes of Unconventional T Cells: γδ T Cells 3 Subtypes of Unconventional T Cells: αβ T Cells Keywords: unconventional T cells; defining unconventional T cells; ‘professional’ antigen-presenting cells (APC); TCR gene cDNA (complementary DNA); murine dendritic epidermal T cells (DETC ...
Adrian Hayday, Carrie Steele
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The clinical landscape of CAR-engineered unconventional T cells
Trends in CancerUnconventional T cells, such as invariant natural killer T (iNKT), γδ T, and mucosal-associated invariant T (MAIT) cells, play a pivotal role in bridging innate and adaptive immunity. Their capacity for rapid tumor targeting and effective modulation of the tumor microenvironment (TME) makes them promising candidates for cancer immunotherapy.
Yan-Ruide Li, Yichen Zhu
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Dysfunctional states of unconventional T-cell subsets in cancer
Journal of Leukocyte Biology, 2023Abstract Unconventional T cells represent a promising therapeutic agent to overcome the current limitations of immunotherapies due to their universal T-cell receptors, ability to respond directly to cytokine stimulation, and capacity to recruit and modulate conventional immune cells in the tumor microenvironment.
Elizabeth N, Katsnelson +7 more
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Unconventional recognition of peptides by T cells and the implications for autoimmunity
Nature Reviews Immunology, 2012The interaction of antigen-presenting cells with free peptides or a denatured protein can give rise to peptide-MHC class II complexes that are distinct from those generated after the processing of the whole protein. Such atypical peptide-MHC complexes can be recognized by unconventional 'type B' T cells that are not a component of the normal immune ...
Emil R. Unanue
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Phenotypical and Functional Characterization of Cytotoxic Unconventional T-Cells
2021During the last two decades, the immunology field has been focused on the study of conventional T-cells, leading to important advances in identification of specific subsets involved in promoting and suppressing immune response in patients with cancer, autoimmune disease or transplanted patients.
Gigante M., Ranieri E.
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Landscape of unconventional γδ T cell subsets in cancer
Molecular Biology ReportsT cells are broadly categorized into two groups, namely conventional and unconventional T cells. Conventional T cells are the most prevalent and well-studied subset of T cells. On the other hand, unconventional T cells exhibit diverse functions shared between innate and adaptive immune cells.
Parviz, Azimnasab-Sorkhabi +3 more
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Activation and Function of Unconventional T Cells
2018Efferent innate immune responses include the function of unconventional T cells with partial innate properties. While most studies of T lymphocytes have focused on T cells involved in adaptive immune responses by reacting to complexes of peptide and major histocompatibility complex proteins, many other types of T cells do not match this paradigm.
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