Results 141 to 150 of about 2,019,877 (178)

An immunohistochemical and in situ hybridisation study of the postnatal development of uncoupling protein-1 and uncoupling protein-1 mRNA in lamb perirenal adipose tissue

Cell and Tissue Research, 1998
In the lamb, the uncoupling protein-1 (UCP1) content of perirenal adipose tissue at birth is an important factor in heat production by non-shivering thermogenesis and the prevention of hypothermia. This study examines UCP1 gene expression and protein content in perirenal adipose tissue over the first 15 days of life by in situ hybridisation and ...
D, Finn, M A, Lomax, P, Trayhurn
openaire   +2 more sources

Uncoupling protein 1: a short-circuit in the chemiosmotic process

Journal of Bioenergetics and Biomembranes, 2008
One of the significant naturally occurring short-circuits in the chemiosmotic process is manifest through the activity of uncoupling protein 1, most notably present in the inner membrane of mitochondria in brown adipose tissue. Much has been learnt about the mechanism of action of uncoupling protein 1 since its discovery in the 1970's, yet many areas ...
openaire   +2 more sources

Uncoupling protein 1 contributes to fat-reducing effect of leptin

Obesity Research & Clinical Practice, 2007
Leptin is proposed to reduce body fat by increasing energy expenditure, in addition to decreasing food intake, through the activation of brown adipose tissue (BAT) thermogenesis. To confirm this, we investigated the effects of leptin on whole body energy expenditure, BAT functions and adiposity in wild-type (WT) mice, and compared with those in mice ...
Yuko, Okamatsu-Ogura, Akihiro, Uozumi, Chitoku, Toda, Kazuhiro, Kimura, Hitoshi, Yamashita, Masayuki, Saito   +5 more
openaire   +2 more sources

The central matrix loop drives import of uncoupling protein 1 into mitochondria

Journal of Cell Science, 2000
ABSTRACT The uncoupling protein (UCP1) is a carrier protein of the inner mitochondrial membrane spanning the bilayer six times. It does not contain a typical amino-terminal targeting signal and the mechanism of targeting and insertion is unknown. Here we focus on the biogenesis of UCP1 by analysing the import signals contained within the
E, Schleiff, H, McBride
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The interaction of mitochondrial Uncoupling Protein-1 with regulatory ligands [PDF]

, 2021
Brown adipose tissue of mammals possesses the specialised ability to oxidise nutrients to generate heat for thermoregulation. In adult humans, the thermogenic capacity of the tissue has attracted much interest for its potential to help combat obesity and metabolic disease.
openaire  

Expression of uncoupling protein 1 in bovine muscle cells.

Journal of animal science, 2017
Uncoupling protein 1 (Ucp1) is predominantly expressed in brown/beige adipocytes in mammals. Although myogenic cells have been suggested to commit to a brown adipocyte lineage through the induction of Prdm16 expression, Prdm16 is also expressed in skeletal muscle. Thus, we examined expression of Ucp1 in bovine myogenic cells. Considering that Ucp1 is a
M A, Abd Eldaim, O, Hashimoto, H, Ohtsuki, T, Yamada, M, Murakami, K, Onda, R, Sato, Y, Kanamori, Y, Qiao, S, Tomonaga, T, Matsui, M, Funaba   +11 more
openaire   +1 more source

Uncoupling protein 1 controls reactive oxygen species in brown adipose tissue

Proceedings of the National Academy of Sciences of the United States of America, 2017
M. Jastroch
semanticscholar   +1 more source

Assessment of uncoupling activity of uncoupling protein 3 using a yeast heterologous expression system

FEBS Letters, 1999
Thilo Hagen, B B Lowell, C Y Zhang
exaly  

Uncoupling Protein-2 Protects Endothelial Function in Diet-Induced Obese Mice

Circulation Research, 2012
Yu Wang, Aimin Xu, Xiaoqiang Yao
exaly  

Uncoupling Protein-1

2008
openaire   +1 more source