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Expression of uncoupling protein 1 in bovine muscle tissues.

Expression of uncoupling protein 1 in bovine muscle tissues.
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Transcriptional regulation of the uncoupling protein-1 gene.

Biochimie, 2017
Regulated transcription of the uncoupling protein-1 (UCP1) gene, and subsequent UCP1 protein synthesis, is a hallmark of the acquisition of the differentiated, thermogenically competent status of brown and beige/brite adipocytes, as well as of the responsiveness of brown and beige/brite adipocytes to adaptive regulation of thermogenic activity.
F. Villarroya, Marion Peyrou, M. Giralt
semanticscholar   +4 more sources

Nucleotide specificity of human uncoupling protein 1 inhibition

Biochimica et Biophysica Acta (BBA) - Bioenergetics
Scott A Jones, Alice P. Sowton, Denis Lacabanne, Martin S. King, Edmund R. S. Kunji   +4 more
semanticscholar   +2 more sources

Uncoupling Proteins 1 and 3 Are Regulated Differently

Biochemistry, 2000
Using a heterologous yeast expression system, we have previously found a marked discordance between the effects of uncoupling protein (UCP) 1 and UCP3L on basal O(2) consumption in whole yeast versus isolated mitochondria. In whole yeast, UCP3L produces a greater stimulation of basal O(2) consumption, while in isolated mitochondria, UCP1 produces a ...
T, Hagen, C Y, Zhang, C R, Vianna, B B, Lowell   +3 more
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Fish Oil Protects Wild Type and Uncoupling Protein 1‐Deficient Mice from Obesity and Glucose Intolerance by Increasing Energy Expenditure

Molecular Nutrition & Food Research, 2019
SCOPE The mechanisms and involvement of uncoupling protein 1 (UCP1) in the protection from obesity and insulin resistance induced by intake of a high-fat diet rich in omega-3 (n-3) fatty acids are investigated. METHODS AND RESULTS C57BL/6J mice are fed
Tiago E. Oliveira, Érique Castro, Thiago Belchior, M. L. Andrade, A. Chaves-Filho, Á. Peixoto, Mayara F Moreno, Milene Ortiz-Silva, R. Moreira, Alex Inague, M. Yoshinaga, S. Miyamoto, N. Moustaid‐Moussa, W. Festuccia   +13 more
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A mitochondrial uncoupling artifact can be caused by expression of uncoupling protein 1 in yeast

Biochemical Journal, 2001
Uncoupling protein 1 (UCP1) from mouse was expressed in yeast and the specific (GDP-inhibitable) and artifactual (GDP-insensitive) effects on mitochondrial uncoupling were assessed. UCP1 provides a GDP-inhibitable model system to help interpret the uncoupling effects of high expression in yeast of other members of the mitochondrial carrier protein ...
J A, Stuart, J A, Harper, K M, Brindle, M B, Jekabsons, M D, Brand   +4 more
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Uncoupling protein 1 expression and high-fat diets

American Journal of Physiology-Regulatory, Integrative and Comparative Physiology, 2011
Uncoupling protein 1 (Ucp1) is the key component of β-adrenergically controlled nonshivering thermogenesis in brown adipocytes. This process combusts stored and nutrient energy as heat. Cold exposure not only activates Ucp1-mediated thermogenesis to maintain normothermia but also results in adaptive thermogenesis, i.e., the recruitment of thermogenic ...
Tobias, Fromme, Martin, Klingenspor
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Uncoupling protein 1 in nonadipose tissue

American Journal of Physiology-Endocrinology and Metabolism
Our findings reveal UCP1 expression begins from E10.5, particularly in the brain, kidney, ear, eye, mammary gland, and reproductive system. During embryonic development, UCP1 expression is more prevalent in nonadipose tissues, compared to adulthood, especially in epithelial cells.
Xi Hu, Donghua Hu, Kun Chen, Mengjiao Xu, Yaying Chen, Lisheng Fu, Deping Wu, Xinkai Qu, Jiqiu Wang, Chengchao Ruan, Junfeng Cai, Kailei Shi, Maoqing Ye   +12 more
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CREG1 promotes uncoupling protein 1 expression and brown adipogenesis in vitro

Journal of Biochemistry (Tokyo), 2018
Brown adipocytes play a critical role for adaptive thermogenesis to regulate body temperature in cold or to circumvent diet-induced obesity. In this study, we investigated the role of cellular repressor of E1A-stimulated genes 1 (CREG1) on brown ...
Tatsuya Kusudo, M. Hashimoto, N. Kataoka, Yongxue Li, Aya Nozaki, H. Yamashita   +5 more
semanticscholar   +1 more source