Results 91 to 100 of about 3,589 (156)

Effects of neonatal hypothyroidism on testicular development and undifferentiated spermatogonia in prepubertal rats

Andrology, Volume 14, Issue 1, Page 196-209, January 2026.
Abstract Background Thyroid hormones play a key role in testicular development, particularly in the regulation of Sertoli cell proliferation and differentiation. While congenital hypothyroidism is common and treatable, the effects of thyroid hormone insufficiency on early testicular development during the neonatal period remain unclear. Objectives This
Daisuke Matsumoto, Kentaro Mizuno, Hidenori Nishio, Hideyuki Kamisawa, Takuya Sakata, Taiki Kato, Akihiro Nakane, Satoshi Kurokawa, Tetsuji Maruyama, Yutaro Hayashi, Takahiro Yasui   +10 more
wiley   +1 more source

Periodic production of retinoic acid by meiotic and somatic cells coordinates four transitions in mouse spermatogenesis [PDF]

, 2017
Mammalian spermatogenesis is an elaborately organized differentiation process, starting with diploid spermatogonia, which include germ-line stem cells, and ending with haploid spermatozoa.
de Rooij, Dirk G., Endo, Tsutomu, Freinkman, Elizaveta, Page, David C   +3 more
core   +1 more source

Germ cell and other tumors in individuals with differences in sex development

CA: A Cancer Journal for Clinicians, Volume 75, Issue 6, Page 587-601, November/December 2025.
Abstract Approximately one in 3500 to one in 5100 live‐born infants have atypical external genital development, known as differences in sex development (DSD). In 2005, an expert consensus conference thoroughly reviewed aspects of health care for individuals with DSD.
Selma Feldman Witchel, Miguel Reyes‐Múgica   +1 more
wiley   +1 more source

Isolation of THY1+ Undifferentiated Spermatogonia from Mouse Postnatal Testes Using Magnetic-activated Cell Sorting (MACS)

Bio-Protocol, 2016
In mammals, homeostasis of many tissues rely on a subpopulation of cells, referred to as stem cells, to sustain an appropriate number of undifferentiated and differentiated cells.
Hung-Fu Liao, Joyce Kuo, Hsien-Hen Lin, Shau-Ping Lin   +3 more
doaj   +1 more source

Health effects in fish of long-term exposure to effluents from wastewater treatment works [PDF]

, 2006
The effects of simple mixtures of chemicals, with similar mechanisms of action, can be predicted using the concentration addition model (CA). The ability of this model to predict the estrogenic effects of more complex mixtures such as effluent discharges,
Babich H, Charles R. Tyler, Han XL, Josephine A. Hagger, Katherine E. Liney, Lee HB, Liehr JG, Michael H. Depledge, Nutter LM, Reimschuessel R, Salice CJ, Sheahan DA, Susan Jobling, Tamara S. Galloway   +13 more
core   +2 more sources

Cannabinoid Receptors Modulate Physiological Remodelling of the Blood–Testis Barrier

Journal of Cellular Physiology, Volume 240, Issue 11, November 2025.
ABSTRACT The endocannabinoid system, including the CB1 and CB2 receptors, has been associated with the modulation of blood–brain barrier and gut barrier. Herein, using CB1 knock‐out male mice, we studied the potential role of these receptors in maintenance of blood–testis barrier (BTB) integrity during the seminiferous epithelium remodelling phase ...
Francesco Manfrevola, Giulia Ricci, Antonio Suglia, Vincenza Grazia Mele, Antonella Migliaccio, Rosanna Chianese, Gilda Cobellis, Teresa Chioccarelli   +7 more
wiley   +1 more source

MRE11 is essential for the long‐term viability of undifferentiated spermatogonia

Cell Proliferation
AbstractIn the meiotic prophase, programmed SPO11‐linked DNA double‐strand breaks (DSBs) are repaired by homologous recombination (HR). The MRE11‐RAD50‐NBS1 (MRN) complex is essential for initiating DNA end resection, the first step of HR. However, residual DNA end resection still occurs in Nbs1 knockout (KO) spermatocytes for unknown reasons. Here, we
Zhenghui Tang, Zhongyang Liang, Bin Zhang, Xiaohui Xu, Peng Li, Lejun Li, Lin‐Yu Lu, Yidan Liu   +7 more
openaire   +2 more sources

The Role of Plzf in Spermatogonial Stem Cell Maintenance and Differentiation: Mapping the Transcriptional Dynamics and Key Interactions

Cells
Spermatogonial stem cells (SSCs) sustain and modulate spermatogenesis through intricate signaling pathways and transcription factors. Promyelocytic leukemia zinc-finger (Plzf, also known as Zbtb16) has been identified as a critical transcription factor ...
Nima Ghasemi, Hossein Azizi, Seyedeh-Kiana Razavi-Amoli, Thomas Skutella   +3 more
doaj   +1 more source

Characterization of spermatogonial stem cells lacking intercellular bridges and genetic replacement of a mutation in spermatogonial stem cells. [PDF]

PLoS ONE, 2012
Stem cells have a potential of gene therapy for regenerative medicine. Among various stem cells, spermatogonial stem cells have a unique characteristic in which neighboring cells can be connected by intercellular bridges.
Naoki Iwamori, Tokuko Iwamori, Martin M Matzuk   +2 more
doaj   +1 more source

Developmental expression of BMP4/ALK3/SMAD5 signaling pathway in the mouse testis: a potential role of BMP4 in spermatogonia differentiation [PDF]

, 2003
It is well established that the c-kit gene plays an essential role in the proliferation of differentiating spermatogonia in prepuberal mice. However, the mechanisms that regulate the onset of spermatogenesis, i.e.
DOLCI IANNINI, S, Geremia, R, Grimaldi, P, Pellegrini, M, Rossi, P   +4 more
core   +2 more sources