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The unfolded protein response: controlling cell fate decisions under ER stress and beyond
Nature Reviews Molecular Cell Biology, 2012Claudio Hetz
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The mammalian unfolded protein response.
Annual Review of Biochemistry, 2003▪ Abstract In the endoplasmic reticulum (ER), secretory and transmembrane proteins fold into their native conformation and undergo posttranslational modifications important for their activity and structure. When protein folding in the ER is inhibited, signal transduction pathways, which increase the biosynthetic capacity and decrease the biosynthetic
M. Schröder, R. Kaufman
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Sphingolipids and the unfolded protein response
Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, 2019The unfolded protein response (UPR) is a response by the endoplasmic reticulum to stress, classically caused by any disruption to cell homeostasis that results in an accumulation in unfolded proteins. However, there is an increasing body of research demonstrating that the UPR can also be activated by changes in lipid homeostasis, including changes in ...
Melissa K. Bennett +3 more
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2017
Under the unfolded protein response (UPR), transcripts encoding the endoplasmic reticulum (ER) chaperones are increased and those encoding proteins synthesized in the ER are decreased. To reproducibly detect such changes of an expression profile, homogeneous growth of plants is desired. In addition, uniform treatment with drugs inducing the UPR is also
Yuji Iwata +2 more
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Under the unfolded protein response (UPR), transcripts encoding the endoplasmic reticulum (ER) chaperones are increased and those encoding proteins synthesized in the ER are decreased. To reproducibly detect such changes of an expression profile, homogeneous growth of plants is desired. In addition, uniform treatment with drugs inducing the UPR is also
Yuji Iwata +2 more
openaire +3 more sources
Molecular Biotechnology, 2006
The unfolded protein response (UPR) is a signal transduction network activated by inhibition of protein folding in the endoplasmic reticulum (ER). The UPR coordinates adaptive responses to this stress situation, including induction of ER resident molecular chaperone and protein foldase expression to increase the protein folding capacity of the ER ...
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The unfolded protein response (UPR) is a signal transduction network activated by inhibition of protein folding in the endoplasmic reticulum (ER). The UPR coordinates adaptive responses to this stress situation, including induction of ER resident molecular chaperone and protein foldase expression to increase the protein folding capacity of the ER ...
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Hypoxia and the Unfolded Protein Response
2007Tumor hypoxia refers to the development of regions within solid tumors in which the oxygen concentration is lower (0-3%) compared to that in most normal tissues (4-9%) (Vaupel and Hockel, 2000). Considerable experimental and clinical evidence exists supporting the notion that hypoxia fundamentally alters the physiology of the tumor towards a more ...
Douglas E. Feldman +4 more
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Control of immune cell function by the unfolded protein response
Nature reviews. Immunology, 2023Giusy Di Conza +3 more
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Endoplasmic reticulum stress and unfolded protein response in cardiovascular diseases
Nature Reviews Cardiology, 2021Jun Ren +4 more
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The unfolded protein response and cancer: a brighter future unfolding?
Journal of Molecular Medicine, 2007Mammalian cells are bathed in an interstitial fluid that has a tightly regulated composition in healthy states. Interstitial fluid provides cells with all the necessary metabolic substrates (oxygen, glucose, amino acids, etc.), and waste molecules are removed by diffusion gradients that are controlled by local vascular perfusion.
A. Graham Pockley +3 more
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The Unfolded Protein Response: From Stress Pathway to Homeostatic Regulation
Science, 2011P. Walter, D. Ron
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