Results 251 to 260 of about 80,560 (274)

Beyond Histones: Unveiling the Functional Roles of Protein Acetylation in Prokaryotes and Eukaryotes

Cell Biology International, EarlyView.
ABSTRACT Lysine acetylation plays a crucial role in cellular processes and is found across various evolutionary organisms. Recent advancements in proteomic techniques revealed the presence of acetylation in thousands of non‐histone proteins. Here, we conducted extensive meta‐analysis of 48 acetylomes spanning diverse organisms, including archaea ...
Bruno Sousa Bonifácio, Ariely Barbosa Leite, Ana Caroline de Castro Nascimento Sousa, Suellen Rodrigues Maran, Antoniel Augusto Severo Gomes, Elton J. R. Vasconcelos, Nilmar Silvio Moretti   +6 more
wiley   +1 more source

Deep Learning for Hyperpolarized NMR of Intrinsically Disordered Proteins Without Resolution Loss: Access to Short‐Lived Intermediates

Chemistry – A European Journal, EarlyView.
Abstract The inherently low sensitivity of solution‐state Nuclear Magnetic Resonance (NMR) has long limited its ability to characterize transient biomolecular states at atomic resolution. While dissolution dynamic nuclear polarization (dDNP) offers a compensating signal enhancement, its broader use has been hindered by rapid polarization decay, causing
Ertan Turhan, Christopher Pötzl, Dörte Brandis, Federico Faglia, Milan Zachrdla, Dennis Kurzbach   +5 more
wiley   +1 more source

Drugging the unfolded protein response in acute leukemias [PDF]

core   +1 more source

Dynamic Combinatorial Chemistry Generates Adaptative Libraries of Glyco‐Dyn[n]Arenes That can Be Templated to Produce Anti‐Adhesive Glycoconjugates Targeting Pseudomonas aeruginosa

Chemistry – A European Journal, EarlyView.
DCC enables the formation of glycocluster libraries through reversible disulfide exchange. Nanomolar ligands for multiple lectins (ConA, LecA, and LecB) were identified in a simple experimental set up, purified, and displayed nanomolar affinity with anti‐infectious properties.
Fanny Demontrond, Yoann Pascal, Marion Donnier‐Maréchal, Corentin Raillon, Baptiste Luton, Clara De La Tramblais, Laurent Vial, David Gueyrard, Wessam Galia, Emmanuelle Berger, Alain Géloën, Benoit Cournoyer, Julien Leclaire, Sébastien Vidal   +13 more
wiley   +1 more source

Beyond Docking: A Multitier Computational Pipeline for USP7 Inhibitor Optimization

ChemMedChem, EarlyView.
A multitier computational strategy discovers potential USP7 inhibitors using similarity‐based virtual screening, physics‐driven molecular simulations, binding free energy estimations, binary QSAR modeling, and steered molecular dynamics analysis. This integrated approach prioritizes and optimizes lead compounds with strong predicted affinity, offering ...
Ehsan Sayyah, Muhammet Eren Ulug, Serdar Durdağı   +2 more
wiley   +1 more source

Broad‐Spectrum Diffusion Coefficient Measurements via Surface Plasmon Resonance: From Thermodynamics to Protein Conformational Disorders

ChemPhysChem, EarlyView.
Recent advancements in surface plasmon resonance protocols and simulations have enhanced the measurement and prediction of diffusion coefficients (D) for chemical species in microfluidic channels. These developments enable precise determination of D values for molecules ranging from a few angstroms to nanometric aggregates, facilitating detailed ...
Giuseppe Stefano Basile, Damiano Calcagno, Nunzio Tuccitto, Diego Sbardella, Giuseppe Grasso   +4 more
wiley   +1 more source

Multiorgan characterization of inflammasome component expression in a rat model of advanced heart failure

ESC Heart Failure, EarlyView.
Abstract Aims Targeting inflammasomes in heart failure (HF) might represent a novel therapeutic option. Nevertheless, previous studies focused only on myocardial inflammasome alterations, and data are scarce regarding their regulation and role in HF‐associated multiorgan dysfunction.
Dávid Nagy, Zsófia Onódi, Márton Kocsis, Artúr Tóth, Tímea Bálint, Attila Oláh, Alex Ali Sayour, Bálint András Barta, Béla Merkely, Péter Ferdinandy, Tamás Radovits, Zoltán V. Varga, Mihály Ruppert   +12 more
wiley   +1 more source

Mitochondrial targets in ischaemic heart disease and heart failure, and their potential for a more efficient clinical translation. A scientific statement of the ESC Working Group on Cellular Biology of the Heart and the ESC Working Group on Myocardial Function

European Journal of Heart Failure, EarlyView.
Improving clinical translation of mitoprotective therapies. 31P MRI, phosphorus‐31 magnetic resonance imaging; hiPSC‐CM, human‐induced pluripotent stem cell‐derived cardiomyocyte; IHD, ischaemic heart disease. Abstract Acute myocardial infarction (MI) remains a major cause of death and disability worldwide.
Melanie Paillard, Mahmoud Abdellatif, Ioanna Andreadou, Christian Bär, Luc Bertrand, Bianca J.J.M. Brundel, Gemma Chiva‐Blanch, Sean M. Davidson, Dana Dawson, Fabio Di Lisa, Paul Evans, Zoltan Giricz, Derek J. Hausenloy, Petra Kleinbongard, Frank Lezoualc'h, Elisa Liehn, Christoph Maack, Ange Maguy, Elizabeth Murphy, Cinzia Perrino, Maurizio Pesce, Peter P. Rainer, Katrin Streckfuss‐Bömeke, Matthias Thielmann, Rong Tian, Carlo G. Tocchetti, Jolanda Van Der Velden, Sophie Van Linthout, Serena Zacchigna, Thomas Krieg   +29 more
wiley   +1 more source

Plant Protein‐Dietary Polyphenol Interactions: Implications for Protein Structural and Functional Properties and Digestibility

Food Chemistry International, EarlyView.
The importance of the plant proteins, their interaction with polyphenols, and the significance of functional properties and digestibility. ABSTRACT The interaction between plant proteins and dietary polyphenols has garnered significant interest due to its impact on the structural, functional, and digestibility properties of proteins.
Harthika Mylvaganam, Fahrul Nurkolis, Apollinaire Tsopmo   +2 more
wiley   +1 more source

Natural Products Targeting Protein Disulfide Isomerases: New Frontiers for Diabetes, Cancer, and Coagulation

Food Frontiers, EarlyView.
PDIA4 is significantly upregulated in response to nutrient overload in pancreatic β‐cells, resulting in aberrant ROS production, β‐cell failure, and diabetes. PDIA4 facilitates cancer development by inhibiting caspase‐mediatedcell death in cancer and promoting VEGF‐mediated protumoral immunity andangiogenesis in the tumor microenvironment, highlighting
Yi‐San Lee, Catherine Ortega, Tien‐Fen Kuo, Greta Yang, Wen‐Chin Yang   +4 more
wiley   +1 more source