New twists in the unfolded protein response
eLife, 2012 The response of S. pombe, also known as fission yeast, to misfolded proteins involves mechanisms that have not been observed in other species.
Benedict C S Cross, David Ron
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Consensus clustering and functional interpretation of gene-expression data [PDF]
, 2004 Microarray analysis using clustering algorithms can suffer from lack of inter-method consistency in assigning related gene-expression profiles to clusters.
Kellam, P. +6 more
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The unfolded protein response in multiple sclerosis
Frontiers in Neuroscience, 2015 The unfolded protein response (UPR) occurs in response to endoplasmic reticulum (ER) stress caused by the accumulation of unfolded or misfolded proteins in the ER.
Wensheng eLin, Sarrabeth eStone
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Fibrillary Glomerulonephritis, DNAJB9, and the Unfolded Protein Response
Glomerular Diseases, 2022 Background: Fibrillary glomerulonephritis (FGN) is found in approximately 1% of native kidney biopsies and was traditionally defined by glomerular deposition of fibrils larger than amyloid (12–24 nm diameter) composed of polyclonal IgG.
Nicole K. Andeen +5 more
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Inhibition of IRE1α-mediated XBP1 mRNA cleavage by XBP1 reveals a novel regulatory process during the unfolded protein response [PDF]
, 2017 Background: The mammalian endoplasmic reticulum (ER) continuously adapts to the cellular secretory load by the activation of an unfolded protein response (UPR).
Bulleid, Neil J. +4 more
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A conformational RNA zipper promotes intron ejection during non-conventional XBP1 mRNA splicing. [PDF]
, 2015 The kinase/endonuclease IRE1 is the most conserved signal transducer of the unfolded protein response (UPR), an intracellular signaling network that monitors and regulates the protein folding capacity of the endoplasmic reticulum (ER).
Acosta-Alvear, Diego +3 more
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The Unfolded Protein Response at the Tumor-Immune Interface
Frontiers in Immunology, 2022 The tumor-immune interface has surged to primary relevance in an effort to understand the hurdles facing immune surveillance and cancer immunotherapy.
Maurizio Zanetti +3 more
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Ethanol Induced Disordering of Pancreatic Acinar Cell Endoplasmic Reticulum: An ER Stress/Defective Unfolded Protein Response Model. [PDF]
, 2018 Background & aimsHeavy alcohol drinking is associated with pancreatitis, whereas moderate intake lowers the risk. Mice fed ethanol long term show no pancreas damage unless adaptive/protective responses mediating proteostasis are disrupted. Pancreatic
Abrol, Ravinder +13 more
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A Systems Biology Approach towards Deciphering the Unfolded Protein Response in Huntington's Disease [PDF]
, 2012 Although the disease causing gene huntingtin has been known for some time, the exact cause of neuronal cell death during _Huntington's disease_ (HD) remains unknown.
Kameshwar R. Ayasolla +2 more
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Unfolded Protein Response and Macroautophagy in Alzheimer’s, Parkinson’s and Prion Diseases
Molecules, 2015 Proteostasis are integrated biological pathways within cells that control synthesis, folding, trafficking and degradation of proteins. The absence of cell division makes brain proteostasis susceptible to age-related changes and neurodegeneration. Two key
Irina Milisav +2 more
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