Results 21 to 30 of about 1,004,483 (288)
XBP-1 Regulates a Subset of Endoplasmic Reticulum Resident Chaperone Genes in the Unfolded Protein Response [PDF]
Molecular and Cellular Biology, 2003 Ann–Hwee Lee +2 more
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A statistical mechanics investigation of unfolded protein response across organisms [PDF]
Scientific ReportsLiving systems rely on coordinated molecular interactions, especially those related to gene expression and protein activity. The Unfolded Protein Response is a crucial mechanism in eukaryotic cells, activated when unfolded proteins exceed a critical ...
Nicole Luchetti +5 more
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The Unfolding Tale of the Unfolded Protein Response [PDF]
Cell, 2001 Surface and secreted proteins are synthesized in the endoplasmic reticulum where they must fold and assemble before being transported. Changes in the ER that interfere with their proper maturation initiate the unfolded protein response pathway. New studies have filled in a missing link between the yeast and mammalian pathways.
Yanjun Ma, Linda M. Hendershot
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The unfolded protein response in virus infections. [PDF]
Frontiers in Microbiology, 2014 Unfolded protein response (UPR) is a cellular adaptive response for restoring endoplasmic reticulum (ER) homeostasis in response to ER stress. Perturbation of the UPR and failure to restore ER homeostasis inevitably leads to diseases. It has now become evident that perturbation of the UPR is the cause of many important human diseases such as ...
Shiu-Wan eChan
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The unfolded protein response [PDF]
Current Biology, 2005 Where does the UPR function? Between the endoplasmic reticulum (ER) and the nucleus of eukaryotic cells. All secreted proteins and proteins that reside in secretory compartments translocate as nascent peptide chains into the ER, where they may undergo folding, modification and assembly before assuming their functional conformations.
Aditi Chawla, Maho Niwa
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Frontiers in Molecular Neuroscience, 2022 Aging and age-related neurodegeneration are both associated with the accumulation of unfolded and abnormally folded proteins, highlighting the importance of protein homeostasis (termed proteostasis) in maintaining organismal health.
Andrew P. K. Wodrich +7 more
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The unfolded protein response in immunity and inflammation [PDF]
Nature Reviews Immunology, 2016 The unfolded protein response (UPR) is a highly conserved pathway that allows the cell to manage endoplasmic reticulum (ER) stress that is imposed by the secretory demands associated with environmental forces. In this role, the UPR has increasingly been shown to have crucial functions in immunity and inflammation.
J. Grootjans +3 more
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The Unfolded Protein Response and Diabetic Retinopathy [PDF]
Journal of Diabetes Research, 2014 Diabetic retinopathy, a common complication of diabetes, is the leading cause of blindness in adults. Diabetes chronically damages retinal blood vessels and neurons likely through multiple pathogenic pathways such as oxidative stress, inflammation, and endoplasmic reticulum (ER) stress.
Jacey Hongjie Ma +2 more
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Unfolded protein response [PDF]
Current Biology, 2012 SummaryIn eukaryotic cells, the endoplasmic reticulum (ER) is a membrane-enclosed interconnected organelle responsible for the synthesis, folding, modification, and quality control of numerous secretory and membrane proteins. The processes of protein folding and maturation are highly assisted and scrutinized but are also sensitive to changes in ER ...
Stewart Siyan Cao, Randal J. Kaufman
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The unfolded protein response protects from tau neurotoxicity in vivo. [PDF]
PLoS ONE, 2010 The unfolded protein response is a critical system by which the cell handles excess misfolded protein in the secretory pathway. The role of the system in modulating the effects of aggregation prone cytosolic proteins has received less attention.
Carin A Loewen, Mel B Feany
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