Results 21 to 30 of about 989,519 (369)
Indonesian Journal of Biotechnology, 2021 Plants activate the unfolded protein response as part of cellular adaptation, thereby maintaining the endoplasmic reticulum homeostasis during external stresses exposure.
Galang Rizki Ramadhan +3 more
doaj +1 more source
The unfolded protein response [PDF]
Journal of Cell Science, 2003 The endoplasmic reticulum (ER) is a principal site for folding and maturation of transmembrane, secretory and ER-resident proteins. Perturbations that alter ER homeostasis can lead to accumulation of unfolded proteins (UPs), which is a threat to all living cells.
Randal J. Kaufman, Chuan Yin Liu
openaire +3 more sources
IRE1β negatively regulates IRE1α signaling in response to endoplasmic reticulum stress [PDF]
, 2020 IRE1β is an ER stress sensor uniquely expressed in epithelial cells lining mucosal surfaces. Here, we show that intestinal epithelial cells expressing IRE1β have an attenuated unfolded protein response to ER stress.
Acosta-Alvear +54 more
core +1 more source
Journal of Hematology & Oncology, 2022 Mitochondria are essential for tumor growth and progression. However, the heavy demand for mitochondrial activity in cancer leads to increased production of mitochondrial reactive oxygen species (mtROS), accumulation of mutations in mitochondrial DNA ...
J. Inigo, D. Chandra
semanticscholar +1 more source
Herpesviruses and the Unfolded Protein Response [PDF]
Viruses, 2019 Herpesviruses usurp cellular stress responses to promote viral replication and avoid immune surveillance. The unfolded protein response (UPR) is a conserved stress response that is activated when the protein load in the ER exceeds folding capacity and misfolded proteins accumulate.
Benjamin P. Johnston +2 more
openaire +4 more sources
Uterine Endoplasmic Reticulum Stress and Its Unfolded Protein Response May Regulate Caspase 3 Activation in the Pregnant Mouse Uterus [PDF]
, 2013 We have previously proposed that uterine caspase-3 may modulate uterine contractility in a gestationally regulated fashion. The objective of this study was to determine the mechanism by which uterine caspase-3 is activated and consequently controlled in ...
Condon, Jennifer C. +5 more
core +6 more sources
Cellular Response to Unfolded Proteins in Depression [PDF]
Life, 2021 Despite many scientific studies on depression, there is no clear conception explaining the causes and mechanisms of depression development. Research conducted in recent years has shown that there is a strong relationship between depression and the endoplasmic reticulum (ER) stress.
Mateusz Kowalczyk +5 more
openaire +3 more sources
Frontiers in Cellular Neuroscience, 2022 Ischemic stroke is an acute cerebrovascular disease characterized by sudden interruption of blood flow in a certain part of the brain, leading to serious disability and death.
Lei Wang +8 more
semanticscholar +1 more source
Regulation of lipid metabolism by the unfolded protein response
Journal of Cellular and Molecular Medicine, 2021 The endoplasmic reticulum (ER) is the site of protein folding and secretion, Ca2+ storage and lipid synthesis in eukaryotic cells. Disruption to protein folding or Ca2+ homeostasis in the ER leads to the accumulation of unfolded proteins, a condition ...
Matthieu Moncan +5 more
semanticscholar +1 more source
Mitochondria Retrograde Signaling and the UPR mt: Where Are We in Mammals? [PDF]
, 2015 Mitochondrial unfolded protein response is a form of retrograde signaling that contributes to ensuring the maintenance of quality control of mitochondria, allowing functional integrity of the mitochondrial proteome. When misfolded proteins or unassembled
Arnould, T., Michel, S., Renard, P.
core +6 more sources