Results 301 to 310 of about 1,143,124 (339)
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2017
Under the unfolded protein response (UPR), transcripts encoding the endoplasmic reticulum (ER) chaperones are increased and those encoding proteins synthesized in the ER are decreased. To reproducibly detect such changes of an expression profile, homogeneous growth of plants is desired. In addition, uniform treatment with drugs inducing the UPR is also
Kazuki, Tabara +2 more
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Under the unfolded protein response (UPR), transcripts encoding the endoplasmic reticulum (ER) chaperones are increased and those encoding proteins synthesized in the ER are decreased. To reproducibly detect such changes of an expression profile, homogeneous growth of plants is desired. In addition, uniform treatment with drugs inducing the UPR is also
Kazuki, Tabara +2 more
openaire +2 more sources
Sphingolipids and the unfolded protein response
Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, 2019The unfolded protein response (UPR) is a response by the endoplasmic reticulum to stress, classically caused by any disruption to cell homeostasis that results in an accumulation in unfolded proteins. However, there is an increasing body of research demonstrating that the UPR can also be activated by changes in lipid homeostasis, including changes in ...
Bennett, M.K. +2 more
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The mitochondrial unfolded protein response and its diverse roles in cellular stress.
International Journal of Biochemistry and Cell Biology, 2021Mitochondrial function is centrally involved in many cellular processes, such as energy production, metabolism of nucleotides, amino acids, and lipids, calcium buffering, and regulation of cell death.
Ioannis Smyrnias
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Hypoxia and the Unfolded Protein Response
2007Tumor hypoxia refers to the development of regions within solid tumors in which the oxygen concentration is lower (0-3%) compared to that in most normal tissues (4-9%) (Vaupel and Hockel, 2000). Considerable experimental and clinical evidence exists supporting the notion that hypoxia fundamentally alters the physiology of the tumor towards a more ...
Constantinos, Koumenis +4 more
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Mitochondrial unfolded protein response: an emerging pathway in human diseases.
Free Radical Biology & Medicine, 2020Mitochondrial unfolded protein response (UPRmt) is a mitochondria stress response, which the transcriptional activation programs of mitochondrial chaperone proteins and proteases are initiated to maintain proteostasis in mitochondria.
Li Zhu, Qionglin Zhou, Lu He, Linxi Chen
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Structural Basis of the Unfolded Protein Response
Annual Review of Cell and Developmental Biology, 2012The unfolded protein response (UPR) is a network of intracellular signaling pathways that maintain the protein-folding capacity of the endoplasmic reticulum (ER) in eukaryotic cells. Dedicated molecular sensors embedded in the ER membrane detect incompletely folded or unfolded proteins in the ER lumen and activate a transcriptional program that ...
Alexei, Korennykh, Peter, Walter
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Translational Control and the Unfolded Protein Response
Antioxidants & Redox Signaling, 2007Cellular stresses that disrupt the processing of proteins slated for the secretory pathway induce the unfolded protein response (UPR), a regulatory network involving both translational and transcriptional control mechanisms that is designed to expand the secretory pathway and alleviate cellular injury.
Ronald C, Wek, Douglas R, Cavener
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Endoplasmic reticulum stress and unfolded protein response in cardiovascular diseases
Nature Reviews Cardiology, 2021Jun Ren +4 more
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Control of immune cell function by the unfolded protein response
Nature reviews. Immunology, 2023Giusy Di Conza +3 more
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The Unfolded Protein Response: From Stress Pathway to Homeostatic Regulation
Science, 2011P. Walter, D. Ron
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