Results 291 to 300 of about 1,143,124 (339)

The PERK signaling pathway as a marker of the unfolded protein response in patients with acute myeloid leukemia. [PDF]

Turk J Med Sci
Erkut N, Köksal T, Demir S, Menteşe A, Balta Ö, Sönmez M.   +5 more
europepmc   +1 more source

KIF5B-driven unfolded protein response reprograms breast cancer immunosuppressive microenvironment for single-cell guided therapeutic targeting. [PDF]

Discov Oncol
Liu Y, Li S, Luo Z, Xia Y, Zhang P.
europepmc   +1 more source

Mucin 2 and unfolded protein response reshape the mucus barrier in inflammatory bowel disease (Review). [PDF]

Mol Med Rep
Yuan Z, Xia Z, Ling L, Xie J, Zhang F.
europepmc   +1 more source

The Role of Endoplasmic Reticulum Stress and Unfolded Protein Response in Gynecological Cancers: A Narrative Review. [PDF]

Cureus
Flindris S, Flindris K, Foutadakis S, Kalinderis M, Traianos A, Kigka VI, Nteka F, Mpourazanis G, Styliara I, Styliara E, Tsirkas P, Petousis S, Margioula-Siarkou C, Navrozoglou I.   +13 more
europepmc   +1 more source

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The unfolded protein response: controlling cell fate decisions under ER stress and beyond

Nature Reviews Molecular Cell Biology, 2012
Claudio Hetz, Hetz Claudio
exaly   +2 more sources

Signal integration in the endoplasmic reticulum unfolded protein response

Nature Reviews Molecular Cell Biology, 2007
David Ron, Peter Walter, Ron David
exaly   +2 more sources

The mammalian unfolded protein response.

Annual Review of Biochemistry, 2003
▪ Abstract  In the endoplasmic reticulum (ER), secretory and transmembrane proteins fold into their native conformation and undergo posttranslational modifications important for their activity and structure. When protein folding in the ER is inhibited, signal transduction pathways, which increase the biosynthetic capacity and decrease the biosynthetic ...
M. Schröder, R. Kaufman
semanticscholar   +3 more sources

ER stress and the unfolded protein response in neurodegeneration [PDF]

Nature Reviews Neurology, 2017
The clinical manifestation of neurodegenerative diseases is initiated by the selective alteration in the functionality of distinct neuronal populations.
C. Hetz, Smita Saxena
semanticscholar   +2 more sources

The mitochondrial unfolded protein response: A multitasking giant in the fight against human diseases.

Ageing Research Reviews, 2022
Mitochondria, which serve as the energy factories of cells, are involved in cell differentiation, calcium homeostasis, amino acid and fatty acid metabolism and apoptosis.
Zixin Zhou, Yumei Fan, Rui-kai Zong, K. Tan   +3 more
semanticscholar   +1 more source

Targeting the unfolded protein response in disease [PDF]

Nature Reviews Drug Discovery, 2013
Artículo de publicación ISIStress induced by the accumulation of unfolded proteins in the endoplasmic reticulum (ER) is a feature of specialized secretory cells and is also observed in many diseases, including cancer, diabetes, autoimmune conditions ...
Claudio Hetz, Eric Chevet, Heather P Harding   +2 more
exaly   +2 more sources