Results 41 to 50 of about 167,289 (308)

PYCR1 inhibition in bone marrow stromal cells enhances bortezomib sensitivity in multiple myeloma cells by altering their metabolism

Molecular Oncology, EarlyView.
This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert, Lauren van den Broecke, Osman Aksoy, Judith Lind, Sonia Vallet, Arne Van der Vreken, Gamze Ates, Ann Massie, Ken Maes, Kim De Veirman, Elke De Bruyne, Karin Vanderkerken, Klaus Podar, Eline Menu   +13 more
wiley   +1 more source

Regulation of Endoplasmic Reticulum Stress-Autophagy: A Potential Therapeutic Target for Ulcerative Colitis

Frontiers in Pharmacology, 2021
Ulcerative colitis (UC) is a chronic nonspecific inflammation that mainly affects the mucosa and submucosa of the rectum and colon. Numerous studies have shown that endoplasmic reticulum stress (ERS)-induced autophagy plays a vital role in the ...
Dan Qiao, Ziwei Zhang, Yali Zhang, Qian Chen, Yujun Chen, Yingjue Tang, Xiong Sun, Zhipeng Tang, Yancheng Dai   +8 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

The endoplasmic reticulum in plant immunity and cell death [PDF]

, 2012
The endoplasmic reticulum (ER) is a highly dynamic organelle in eukaryotic cells and a major production site of proteins destined for vacuoles, the plasma membrane, or apoplast in plants.
Eichmann, Ruth, Schäfer, P. (Patrick)
core   +2 more sources

Overexpression of factor VIII after AAV delivery is transiently associated with cellular stress in hemophilia A mice

Molecular Therapy: Methods & Clinical Development, 2016
Factor VIII (FVIII) is a large glycoprotein that is challenging to express both in vitro and in vivo. Several studies suggest that high levels of FVIII expression can lead to cellular stress.
Amy M Lange, Ekaterina S Altynova, Giang N Nguyen, Denise E Sabatino   +3 more
doaj   +1 more source

IRE1-independent gain control of the unfolded protein response. [PDF]

PLoS Biology, 2004
Nonconventional splicing of the gene encoding the Hac1p transcription activator regulates the unfolded protein response (UPR) in Saccharomyces cerevisiae. This simple on/off switch contrasts with a more complex circuitry in higher eukaryotes.
Jess H Leber, Sebastián Bernales, Peter Walter   +2 more
doaj   +1 more source

Rethinking plastic waste: innovations in enzymatic breakdown of oil‐based polyesters and bioplastics

FEBS Open Bio, EarlyView.
Plastic pollution remains a critical environmental challenge, and current mechanical and chemical recycling methods are insufficient to achieve a fully circular economy. This review highlights recent breakthroughs in the enzymatic depolymerization of both oil‐derived polyesters and bioplastics, including high‐throughput protein engineering, de novo ...
Elena Rosini, Nicolò Antonelli, Gianluca Molla   +2 more
wiley   +1 more source

The fail-safe mechanism of post-transcriptional silencing of unspliced HAC1 mRNA

eLife, 2016
HAC1 encodes a transcription factor that is the central effector of the unfolded protein response (UPR) in budding yeast. When the UPR is inactive, HAC1 mRNA is stored as an unspliced isoform in the cytoplasm and no Hac1 protein is detectable.
Rachael Di Santo, Soufiane Aboulhouda, David E Weinberg   +2 more
doaj   +1 more source

HSP70 governs permeability and mechanotransduction in primary human endothelial cells

FEBS Open Bio, EarlyView.
HSP70 chemical inhibition reduces endothelial cell proliferation and increases permeability, the latter supported by normal interendothelial junctional protein distribution. HSP70 also plays a role in shear stress response, a hemodynamic force naturally present in blood vessels and correlated with vessel protection.
Andrea Pinto‐Martinez, Everton G. Melo, Isadora C. B. Pavan, Percíllia V. S. Oliveira, Luiza B. C. T. Coimbra, Thaís L. S. Araujo   +5 more
wiley   +1 more source

CCPG1 Is a Non-canonical Autophagy Cargo Receptor Essential for ER-Phagy and Pancreatic ER Proteostasis [PDF]

, 2018
Mechanisms of selective autophagy of the ER, known as ER-phagy, require molecular delineation, particularly in vivo. It is unclear how these events control ER proteostasis and cellular health.
Adamson, Alain J. Kemp, Alex von Kriegsheim, Antonucci, Axe, B'Chir, Behrends, Chen, Christian Behrends, Cox, Deosaran, Di Bartolomeo, Diakopoulos, Dunlop, Edwards, Egan, Farré, Fracchiolla, Fumagalli, Gammoh, Ganley, Ge, Grasso, Grumati, Hailey, Hamasaki, Hara, Hashimoto, Hayashi-Nishino, Heo, Hess, Hosokawa, Houck, Huh, Huttlin, Ichimura, Itakura, Jia, Jimi Wills, Joo, Jung, Kamber, Khaminets, Khaminets, Kim, Kostenko, Kraft, Ktistakis, Lazarou, Lee, Lin, Lipatova, Liu, Longatti, Lum, Maejima, Mali, Margaret E. Harley, Mark Arends, Martin Lee, Matthew D. Smith, Mizushima, Mochida, Newman, Newman, Nguyen, Ogata, Pankiv, Pengo, Ran, Ravikumar, Rouschop, Russell, Simon Wilkinson, Slobodkin, Sowa, Teckman, Thurston, Tian, Tooze, Tooze, Torggler, Tsuboyama, Wang, Wild, Wisniewski, Wong, Zheng   +87 more
core   +1 more source