Results 41 to 50 of about 1,004,483 (288)
Unpacking the Unfolded Protein Response [PDF]
Cell, 2014 This year, the Albert Lasker Basic Medical Research Award will be shared by Peter Walter and Kazutoshi Mori for discoveries revealing the molecular mechanism of the unfolded protein response, an intracellular quality control system that detects harmful misfolded proteins in the endoplasmic reticulum and then signals the nucleus to carry out corrective ...
Jack E. Dixon, Carolyn A. Worby
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Regulation of lipid metabolism by the unfolded protein response
Journal of Cellular and Molecular Medicine, 2021 The endoplasmic reticulum (ER) is the site of protein folding and secretion, Ca2+ storage and lipid synthesis in eukaryotic cells. Disruption to protein folding or Ca2+ homeostasis in the ER leads to the accumulation of unfolded proteins, a condition ...
Matthieu Moncan +5 more
semanticscholar +1 more source
Unfolded Protein Response and Cancer [PDF]
Discoveries, 2014 Physiological stresses, such as hypoxia and oxidative stress, induce protein misfolding in the endoplasmic reticulum (ER). If proteasome degradation fails to remove the misfolded proteins, these proteins accumulate in the ER, triggering the unfolded protein response (UPR).
Shudong Zhu, Mary Chou, Lihua Wu
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Unfolded Protein Corona Surrounding Nanotubes Influence the Innate and Adaptive Immune System
Advanced Science, 2021 The plasma proteins around nanoparticles (NPs) form an outer protein corona, significantly influencing the subsequent immune response. However, it was uncertain whether the protein corona around NPs influences immune response.
Jun‐Young Park +6 more
doaj +1 more source
Melanoma and the Unfolded Protein Response [PDF]
Cancers, 2016 The UPR (unfolded protein response) has been identified as a key factor in the progression and metastasis of cancers, notably melanoma. Several mediators of the UPR are upregulated in cancers, e.g., high levels of GRP78 (glucose-regulator protein 78 kDa) correlate with progression and poor outcome in melanoma patients.
Swetlana Mactier +2 more
openaire +3 more sources
PLoS Pathogens, 2021 Coronavirus infection induces the unfolded protein response (UPR), a cellular signalling pathway composed of three branches, triggered by unfolded proteins in the endoplasmic reticulum (ER) due to high ER load.
Liliana Echavarría-Consuegra +15 more
semanticscholar +1 more source
An unfolded protein-induced conformational switch activates mammalian IRE1. [PDF]
, 2017 The unfolded protein response (UPR) adjusts the cell's protein folding capacity in the endoplasmic reticulum (ER) according to need. IRE1 is the most conserved UPR sensor in eukaryotic cells.
Acosta-Alvear, Diego +5 more
core +3 more sources
Applied Microbiology and Biotechnology, 2021 Folding and processing of proteins in the endoplasmic reticulum (ER) are major impediments in the production and secretion of proteins from Pichia pastoris (Komagataella sp.).
Hana Raschmanová +4 more
semanticscholar +1 more source
UPR Signal Activation by Luminal Sensor Domains [PDF]
, 2013 The unfolded protein response (UPR) is a cell-signaling system that detects the accumulation of unfolded protein within the endoplasmic reticulum (ER) and initiates a number of cellular responses to restore ER homeostasis.
Ali, Maruf +2 more
core +1 more source
The unfolded protein response has a protective role in yeast models of classic galactosemia
Disease Models & Mechanisms, 2014 Classic galactosemia is a human autosomal recessive disorder caused by mutations in the GALT gene (GAL7 in yeast), which encodes the enzyme galactose-1-phosphate uridyltransferase.
Evandro A. De-Souza +6 more
doaj +1 more source