Results 41 to 50 of about 989,519 (369)
Unfolded Protein Responses With or Without Unfolded Proteins? [PDF]
Cells, 2012 The endoplasmic reticulum (ER) is the site of secretory protein biogenesis. The ER quality control (QC) machinery, including chaperones, ensures the correct folding of secretory proteins. Mutant proteins and environmental stresses can overwhelm the available QC machinery.
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Untangling the unfolded protein response [PDF]
Cell Cycle, 2008 Resistance to current cancer therapies has forced scientists to investigate new avenues of therapy distinct from those aimed at single targets, to strategies based on targeting families of proteins, on which cancers rely for their ability to survive stress.
Faith E. Davies +2 more
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Unfolded Protein Response in Arabidopsis [PDF]
, 2017 The unfolded protein response (UPR) is a highly regulated signaling pathway that is largely conserved across eukaryotes. It is essential for cell homeostasis under environmental and physiological conditions that perturb the protein folding in the endoplasmic reticulum (ER).
Cristina Ruberti, Federica Brandizzi
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Tidy up - The unfolded protein response in sepsis
Frontiers in Immunology, 2022 Pathogens, their toxic byproducts, and the subsequent immune reaction exert different forms of stress and damage to the tissue of the infected host. This stress can trigger specific transcriptional and post-transcriptional programs that have evolved to ...
Wolfgang Vivas +5 more
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Endoplasmic Reticulum Stress and Unfolded Protein Response in Neurodegenerative Diseases
International Journal of Molecular Sciences, 2020 The endoplasmic reticulum (ER) is an important organelle involved in protein quality control and cellular homeostasis. The accumulation of unfolded proteins leads to an ER stress, followed by an adaptive response via the activation of the unfolded ...
Rose Ghemrawi, Mostafa Khair
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eLife, 2015 Eukaryotic cells possess a variety of signaling pathways that prevent accumulation of unfolded and misfolded proteins. Chief among these is the heat shock response (HSR), which is assumed to respond to unfolded proteins in the cytosol and nucleus alike ...
Yusuke Miyazaki +4 more
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StresSeed: The Unfolded Protein Response During Seed Development
Frontiers in Plant Science, 2022 During seed development, the endoplasmic reticulum (ER) takes care of the synthesis and structural maturation of very high amounts of storage proteins in a relatively short time.
Alessandro Vitale, Emanuela Pedrazzini
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Wolfram Syndrome protein, Miner1, regulates sulphydryl redox status, the unfolded protein response, and Ca2+ homeostasis. [PDF]
, 2013 Miner1 is a redox-active 2Fe2S cluster protein. Mutations in Miner1 result in Wolfram Syndrome, a metabolic disease associated with diabetes, blindness, deafness, and a shortened lifespan.
Andreyev, Alexander Y +12 more
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Haematologica, 2012 Background Multiple myeloma, a malignancy of the antibody-secreting plasma cells, remains incurable by current therapy. However, the proteasome inhibitor bortezomib and other new drugs are revolutionizing its treatment.
Silvia C. W. Ling +11 more
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Evolution of the Unfolded Protein Response in Plants.
Plant, Cell and Environment, 2021 The Unfolded Protein Response (UPR) in plants is elicited by endoplasmic reticulum stress which can be brought about by adverse environmental conditions.
S. Howell
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