Results 71 to 80 of about 1,004,483 (288)

The Unfolded Protein Response at the Tumor-Immune Interface

Frontiers in Immunology, 2022
The tumor-immune interface has surged to primary relevance in an effort to understand the hurdles facing immune surveillance and cancer immunotherapy.
Maurizio Zanetti, Su Xian, Magalie Dosset, Hannah Carter   +3 more
doaj   +1 more source

Unfolded protein response (UPR) integrated signaling networks determine cell fate during hypoxia

Cellular & Molecular Biology Letters, 2020
During hypoxic conditions, cells undergo critical adaptive responses that include the up-regulation of hypoxia-inducible proteins (HIFs) and the induction of the unfolded protein response (UPR).
Sylwia Bartoszewska, J. Collawn
semanticscholar   +1 more source

Ethanol Induced Disordering of Pancreatic Acinar Cell Endoplasmic Reticulum: An ER Stress/Defective Unfolded Protein Response Model. [PDF]

, 2018
Background & aimsHeavy alcohol drinking is associated with pancreatitis, whereas moderate intake lowers the risk. Mice fed ethanol long term show no pancreas damage unless adaptive/protective responses mediating proteostasis are disrupted. Pancreatic
Abrol, Ravinder, Capri, Joseph, Cohn, Whitaker, Faull, Kym F, Freeman, Michael R, Lugea, Aurelia, Pandol, Stephen J, Piplani, Honit, Sakkiah, Sugunadevi, Su, Hsin-Yuan, Waldron, Richard T, Whitelegge, Julian P, Yang, Wei, Zhou, Bo   +13 more
core   +3 more sources

Structure and Molecular Mechanism of ER Stress Signaling by the Unfolded Protein Response Signal Activator IRE1

Frontiers in Molecular Biosciences, 2019
The endoplasmic reticulum (ER) is an important site for protein folding and maturation in eukaryotes. The cellular requirement to synthesize proteins within the ER is matched by its folding capacity.
Christopher J. Adams, M. Kopp, Natacha Larburu, Piotr R. Nowak, Maruf M. U. Ali   +4 more
semanticscholar   +1 more source

The Unfolded Protein Response in Amelogenesis and Enamel Pathologies [PDF]

, 2017
During the secretory phase of their life-cycle, ameloblasts are highly specialized secretory cells whose role is to elaborate an extracellular matrix that ultimately confers both form and function to dental enamel, the most highly mineralized of all ...
Barron, Bartlett, Basseri, Brookes, Brookes, Brookes, Brookes, Chen, Chlubek, Coelho, Credle, Den Besten, Denny, Dey, DiGiuseppe, Dobson, Eletto, Fava, Fribley, Galvan, Gardner, Gonzales, Gregersen, Han, Harding, Hassunuma, Hetz, Hetz, Hetz, Hollien, Hu, Inkielewicz-Stepniak, Iwasaki, Joseph, Joseph, Joseph, Kim, Kimata, Kopito, Kubota, Lacruz, Lakshminarayanan, Lee, Li, Li, Lin, Malhotra, Malhotra, Matsuo, Melchior, Moore, Moore, Moradian-Oldak, Moukdar, Nishio, Nomura, Novosyadlyy, Oakes, Ow, Ozcan, Paine, Prischi, Puthalakath, Reith, Ron, Rutkowski, Ryu, Santos, Schonthal, Schroder, Schubert, Selkoe, Sharma, Sharma, Sire, Smith, Smith, Smith, Smith, Su, Suzuki, Suzuki, Tabas, Tanabe, Teske, Tsuchiya, Tsuru, Tye, Upton, Valastyan, Vilatoba, Wang, Wei, Wu, Yam, Yoshida, Yue, Zhu, Zode   +98 more
core   +2 more sources

Unfolded Protein Response and Macroautophagy in Alzheimer’s, Parkinson’s and Prion Diseases

Molecules, 2015
Proteostasis are integrated biological pathways within cells that control synthesis, folding, trafficking and degradation of proteins. The absence of cell division makes brain proteostasis susceptible to age-related changes and neurodegeneration. Two key
Irina Milisav, Dušan Šuput, Samo Ribarič   +2 more
doaj   +1 more source

Unfolded protein response is activated in Lewy body dementias [PDF]

, 2018
K
Aarsland, Dag, Attems, Johannes, Baek, Jean-Ha, Ballard, Clive G., Bereczki, Erika, Francis, Paul T., Hortobágyi, Tibor, Howlett, David R., Whitfield, David   +8 more
core   +1 more source

When is the unfolded protein response not the unfolded protein response?

Plant Science, 2017
As sessile organisms, plants are subjected to variety of stresses for which they have evolved different protection mechanisms. One mechanism involves endoplasmic reticulum (ER) stress in which the process of protein folding is disturbed and misfolded proteins accumulate in the ER. ER stress elicits the unfolded protein response (UPR) whereby the stress
openaire   +3 more sources

Stress Management: How the Endoplasmic Reticulum Mitigates Protein Misfolding and Oxidative Stress by the Dual Role of Glutathione Peroxidase 8

Biomolecules
The endoplasmic reticulum mediates essential processes such as protein folding, transport, and post-translational modifications. Disruptions in endoplasmic reticulum function can lead to the accumulation of unfolded or misfolded proteins, initiating ...
Yong Yang, Hao Peng, Danni Meng, Zizhu Fa, Chen Yao, Xinyu Lin, Joel Schick, Xiang Jin   +7 more
doaj   +1 more source

Treatment with the HIV protease inhibitor nelfinavir triggers the unfolded protein response and may overcome proteasome inhibitor resistance of multiple myeloma in combination with bortezomib: a phase I trial (SAKK 65/08)

Haematologica, 2016
Downregulation of the unfolded protein response mediates proteasome inhibitor resistance in multiple myeloma. The Human Immunodeficieny Virus protease inhibitor nelfinavir activates the unfolded protein response in vitro.
Christoph Driessen, Marianne Kraus, Markus Joerger, Hilde Rosing, Jürgen Bader, Felicitas Hitz, Catherine Berset, Alexandros Xyrafas, Hanne Hawle, Gregoire Berthod, Hermann S. Overkleeft, Christiana Sessa, Alwin Huitema, Thomas Pabst, Roger von Moos, Dagmar Hess, Ulrich J.M. Mey   +16 more
doaj   +1 more source