Results 91 to 100 of about 52,959 (267)

Activation of the unfolded protein response is required for defenses against bacterial pore-forming toxin in vivo.

PLoS Pathogens, 2008
Pore-forming toxins (PFTs) constitute the single largest class of proteinaceous bacterial virulence factors and are made by many of the most important bacterial pathogens. Host responses to these toxins are complex and poorly understood. We find that the
Larry J Bischof, Cheng-Yuan Kao, Ferdinand C O Los, Manuel R Gonzalez, Zhouxin Shen, Steven P Briggs, F Gisou van der Goot, Raffi V Aroian   +7 more
doaj   +1 more source

Zhangfei/CREB-ZF - a potential regulator of the unfolded protein response. [PDF]

PLoS ONE, 2013
Cells respond to perturbations in the microenvironment of the endoplasmic reticulum (ER), and to the overloading of its capacity to process secretory and membrane-associate proteins, by activating the Unfolded Protein Response (UPR).
Rui Zhang, Noreen Rapin, Zhengxin Ying, Erika Shklanka, Timothy W Bodnarchuk, Valerie M K Verge, Vikram Misra   +6 more
doaj   +1 more source

An Opto‐Actuated Hydrogel for Cell Mechanoactuation and Real‐Time Force Monitoring

Advanced Science, EarlyView.
Researchers developed a mechanoactuated hydrogel interface where nanomachines exert forces on adhesion receptors and allow monitoring of traction force responses in real time. They demonstrate reversible talin recruitment, enhanced F‐actin polymerization, and a reduction in cell traction force when force is locally applied to focal adhesions of ...
Rinku Kumar, Marc A. Fernandez‐Yague, Adrien Bessaguet, Hosoowi Lee, Nicolas Giuseppone, Andrés J. García, Aránzazu del Campo   +6 more
wiley   +1 more source

IRE1 phosphatase PP2Ce regulates adaptive ER stress response in the postpartum mammary gland. [PDF]

, 2013
We recently reported that the PPM1l gene encodes an endoplasmic reticulum (ER) membrane targeted protein phosphatase (named PP2Ce) with highly specific activity towards Inositol-requiring protein-1 (IRE1) and regulates the functional outcome of ER stress.
Lane, Timothy F, Lu, Gang, Ota, Asuka, Ren, Shuxun, Vondriska, Thomas M, Wang, Yibin, Zhou, Z Hong   +6 more
core   +2 more sources

Endoplasmic Reticulum Stress in Intestinal Epithelial Cell Function and Inflammatory Bowel Disease

Gastroenterology Research and Practice, 2015
In eukaryotic cells, perturbation of protein folding homeostasis in the endoplasmic reticulum (ER) causes accumulation of unfolded and misfolded proteins in the ER lumen, which activates intracellular signaling pathways termed the unfolded protein ...
Katherine Luo, Stewart Siyan Cao
doaj   +1 more source

CircTspan3 Promotes Cartilage Development Through ANNEXIN A2‐Mediated Ferroptosis and Apoptosis Inhibition and Exosome‐Mediated Paracrine Signaling

Advanced Science, EarlyView.
This study reveals that XBP1s drives production of circTspan3, a circular RNA that strengthens cartilage by boosting anabolic activity and limiting cell death. Phosphorylated ANXA2 directs circTspan3 into exosomes, enabling paracrine repair. Exosomal circTspan3 expands growth‐plate cartilage and promotes in vivo regeneration, highlighting its promise ...
Yiming Pan, Fengmei Zhang, Jiayan Zhong, Qian Gong, Nana Geng, Biao Kuang, Qiumei Lan, Miao Yi, Qiqi Zeng, Cheng Chen, Mengtian Fan, Chunliang Zhao, Deping Zeng, Yu Du, Mao Nie, Zhibiao Wang, Fengjin Guo   +16 more
wiley   +1 more source

STING-mediated disruption of calcium homeostasis chronically activates ER stress and primes T cell death [PDF]

, 2019
STING gain-of-function mutations cause lung disease and T cell cytopenia through unknown mechanisms. Here, we found that these mutants induce chronic activation of ER stress and unfolded protein response (UPR), leading to T cell death by apoptosis in ...
Chen, Yu-Ju, Dobbs, Nicole, Liou, Jen, Miner, Jonathan J, Sakai, Tomomi, Wu, Jianjun, Yan, Nan   +6 more
core   +1 more source

The proteasome biogenesis regulator Rpn4 cooperates with the unfolded protein response to promote ER stress resistance

, 2019
Misfolded proteins in the endoplasmic reticulum (ER) activate the unfolded protein response (U PR), which enhances protein folding to restore homeostasis.
Aviram, Barlowe, Berner, Bicknell, Bonilla, Boos, Bosis, Braakman, Chen, Christiano, Conz, Cox, Cox, Cox, Dohmen, Finger, Foresti, Foresti, Gasch, Gething, Goldberg, Görner, Hahn, Hahn, Hahn, Hallstrom, Hampton, Hanssum, Hao, Harbison, Higuchi-Sanabria, Hitchcock, Ho, Hou, Huebert, Itzhak, Janke, Jelinsky, Jonikas, Kawaguchi, Khmelinskii, Kim, Knop, Kostova, Leber, Lee, Liu, Longtine, Mannhaupt, Martínez-Pastor, Meiners, Metzger, Mitsiades, Mumberg, Nasmyth, Ng, Ng, Nishitoh, Obeng, Owsianik, Patil, Pincus, Pincus, Prasad, Radhakrishnan, Rapoport, Rousseau, Schuck, Sikorski, Spear, Spear, Sprouffske, Steffen, Stirling, Szoradi, Tkach, Travers, Tyanova, Verghese, Vogel, Walter, Wang, Wang, Wrobel, Xie, Yamamoto, Young, Zheng   +87 more
core   +1 more source

Engineered GM1 Intersects Between Mitochondrial and Synaptic Pathways to Ameliorate ALS Pathology

Advanced Science, EarlyView.
Amyotrophic Lateral Sclerosis (ALS) is a fatal neurodegenerative disease driven by genetic and molecular disruptions affecting energy balance, protein homeostasis, and stress responses in nerve cells. Studies using human and rodent models identified convergent defects in mitochondria and synaptic function.
Federica Pilotto, Tristan Dellazizzo Toth, Silvano Bond, Alexander Schmitz, Rim Diab, Sara Y. Ngo Tenlep, Brian Mooney, Silvia Erni, Martina Schobesberger, Olivier Scheidegger, Camille Peitsch, Smita Saxena   +11 more
wiley   +1 more source

Ethanol Induced Disordering of Pancreatic Acinar Cell Endoplasmic Reticulum: An ER Stress/Defective Unfolded Protein Response Model. [PDF]

, 2018
Background & aimsHeavy alcohol drinking is associated with pancreatitis, whereas moderate intake lowers the risk. Mice fed ethanol long term show no pancreas damage unless adaptive/protective responses mediating proteostasis are disrupted. Pancreatic
Abrol, Ravinder, Capri, Joseph, Cohn, Whitaker, Faull, Kym F, Freeman, Michael R, Lugea, Aurelia, Pandol, Stephen J, Piplani, Honit, Sakkiah, Sugunadevi, Su, Hsin-Yuan, Waldron, Richard T, Whitelegge, Julian P, Yang, Wei, Zhou, Bo   +13 more
core   +3 more sources