Results 121 to 130 of about 52,959 (267)

28* Study of the unfolded protein response (UPR) in cystic fibrosis (CF)

Journal of Cystic Fibrosis, 2007
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Kerbiriou, M., Trouvé, P., Férec, C.
openaire   +2 more sources

Resilience to Endoplasmic Reticulum Stress Mitigates Membrane Hyperexcitability Underlying Late Disease Onset in a Murine Model of SCA6

Annals of Neurology, EarlyView.
Objective An enduring puzzle in many inherited neurological disorders is the late onset of symptoms despite expression of function‐impairing mutant protein early in life. We examined the basis for onset of impairment in spinocerebellar ataxia type 6 (SCA6), a canonical late‐onset neurodegenerative ataxia which results from a polyglutamine expansion in ...
Haoran Huang, Taylor L. Charron, Min Fu, Miranda Dunn, Deborah M. Jones, Praveen Kumar, Satoshi Ishishita, Allan‐Hermann Pool, Ashwinikumar Kulkarni, Genevieve Konopka, Vikram G. Shakkottai   +10 more
wiley   +1 more source

Methods for Monitoring Endoplasmic Reticulum Stress and the Unfolded Protein Response

International Journal of Cell Biology, 2010
The endoplasmic reticulum (ER) is the site of folding of membrane and secreted proteins in the cell. Physiological or pathological processes that disturb protein folding in the endoplasmic reticulum cause ER stress and activate a set of signaling ...
Afshin Samali, Una FitzGerald, Shane Deegan, Sanjeev Gupta   +3 more
doaj   +1 more source

Navigating the Genetic Risk of Chemotherapy‐Induced Hearing Loss in the Stria Vascularis

Clinical Pharmacology &Therapeutics, EarlyView.
Cisplatin is a chemotherapy drug that causes permanent hearing loss by damaging a critical tissue lining the inner ear, called the stria vascularis (SV). Currently, the molecular mechanisms of SV damage are largely unknown and the incidence of ototoxicity in patients cannot be reliably predicted.
Tara Lazetic, Deanne Nixie R. Miao, Britt I. Drögemöller, Alain Dabdoub, Julia M. Abitbol   +4 more
wiley   +1 more source

A conformational RNA zipper promotes intron ejection during non-conventional XBP1 mRNA splicing. [PDF]

, 2015
The kinase/endonuclease IRE1 is the most conserved signal transducer of the unfolded protein response (UPR), an intracellular signaling network that monitors and regulates the protein folding capacity of the endoplasmic reticulum (ER).
Acosta-Alvear, Diego, Mendez, Aaron S, Peschek, Jirka, Walter, Peter   +3 more
core   +1 more source

A New Role for Estrogen Receptor α in Cell Proliferation and Cancer: Activating the Anticipatory Unfolded Protein Response

Frontiers in Endocrinology, 2018
Cells react to a variety of stresses, including accumulation of unfolded or misfolded protein, by activating the endoplasmic reticulum (EnR) stress sensor, the unfolded protein response (UPR).
Mara Livezey, Ji Eun Kim, David J. Shapiro, David J. Shapiro   +3 more
doaj   +1 more source

Differential Proteomic Analysis to Reveal the Mechanism of Heat Damage in Soybean Using a Data‐Independent Acquisition (DIA) Strategy

Food Safety and Health, EarlyView.
Heat‐stressed soybeans adapt to elevated temperatures through coordinate regulation of destructive and protective protein expression ‐ suppressing detrimental proteins while enhancing beneficial ones. ABSTRACT Soybean represents the largest imported agricultural product in China. Imported soybeans are typically transported via maritime shipping. During
Pengdi Ding, Qinfei Xie, Jiajing Duan, Yinghao Feng, Fengzhong Wang, Yufeng Sun   +5 more
wiley   +1 more source

Projected Warming of the Southern Ocean Disrupts Embryonic Development and Hatch Timing in Antarctic Fish

Global Change Biology Communications, EarlyView.
Embryos are particularly sensitive to thermal challenge. Antarctic fish embryos raised at projected Southern Ocean temperatures hatch during the winter, have a high incidence of morphological abnormalities, have shorter body lengths, and express genes indicative of cellular stress.
Margaret Streeter, Nathalie R. Le François, Thomas Desvignes, Jacob Grondin, John H. Postlethwait, H. William Detrich III, Jacob M. Daane   +6 more
wiley   +1 more source

Management of the endoplasmic reticulum stress by activation of the heat shock response in yeast [PDF]

, 2014
In yeast Saccharomyces cerevisiae, accumulation of misfolded proteins in the endoplasmic reticulum (ER) causes ER stress and activates the unfolded protein response (UPR), which is mediated by Hac1p.
Bandhakavi, Bharadwaj, Brown, Caldwell, Castells-Roca, Ciplys, Dina Petranovic, Eastmond, Erkine, Geiler-Samerotte, Hahn, Hahn, Harbison, Hauptmann, Haynes, Hongting Tang, Jens Nielsen, Jin Hou, Kimata, Liu, Livak, Metzger, Mumberg, Neef, Nishikawa, Oliveira, Patil, Petranovic, Pineau, Plemper, Raitt, Rasheva, Rowley, Ruenwai, Sampaio-Marques, Sewell, Tan, Taxis, Tobias Österlund, Tokunaga, Travers, Tu, Tyo, Wu, Zihe Liu   +44 more
core   +1 more source

Unfolding the role of stress response signaling in endocrine resistant breast cancers

Frontiers in Oncology, 2015
The unfolded protein response (UPR) is an ancient stress response that enables a cell to manage the energetic stress that accompanies protein folding.
Robert eClarke, Katherine L Cook
doaj   +1 more source