Autophagy counterbalances endoplasmic reticulum expansion during the unfolded protein response. [PDF]
PLoS Biology, 2006 The protein folding capacity of the endoplasmic reticulum (ER) is regulated by the unfolded protein response (UPR). The UPR senses unfolded proteins in the ER lumen and transmits that information to the cell nucleus, where it drives a transcriptional ...
Sebastián Bernales +2 more
doaj +1 more source
Inhibition of IRE1α-mediated XBP1 mRNA cleavage by XBP1 reveals a novel regulatory process during the unfolded protein response [PDF]
, 2017 Background: The mammalian endoplasmic reticulum (ER) continuously adapts to the cellular secretory load by the activation of an unfolded protein response (UPR).
Bulleid, Neil J. +4 more
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Frontiers in Endocrinology, 2018 Cells react to a variety of stresses, including accumulation of unfolded or misfolded protein, by activating the endoplasmic reticulum (EnR) stress sensor, the unfolded protein response (UPR).
Mara Livezey +3 more
doaj +1 more source
BMEMat, EarlyView.This review highlights the complex roles of cellular senescence in cancer progression and suppression, discusses the mechanisms and regulatory pathways involved, and evaluates the efficacy of the “One‐Two punch” sequential treatment approach while addressing emerging challenges in this novel therapeutic strategy.
Qiuming Pan +12 more
wiley +1 more source
Methods for Monitoring Endoplasmic Reticulum Stress and the Unfolded Protein Response
International Journal of Cell Biology, 2010 The endoplasmic reticulum (ER) is the site of folding of membrane and secreted proteins in the cell. Physiological or pathological processes that disturb protein folding in the endoplasmic reticulum cause ER stress and activate a set of signaling ...
Afshin Samali +3 more
doaj +1 more source
Yeast Bax Inhibitor, Bxi1p, Is an ER-Localized Protein that Links the Unfolded Protein Response and Programmed Cell Death in \u3cem\u3eSaccharomyces cerevisiae\u3c/em\u3e [PDF]
, 2011 Bax inhibitor-1 (BI-1) is an anti-apoptotic gene whose expression is upregulated in a wide range of human cancers. Studies in both mammalian and plant cells suggest that the BI-1 protein resides in the endoplasmic reticulum and is involved in the ...
Austriaco, Nicanor +4 more
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Uterine Endoplasmic Reticulum Stress and Its Unfolded Protein Response May Regulate Caspase 3 Activation in the Pregnant Mouse Uterus [PDF]
, 2013 We have previously proposed that uterine caspase-3 may modulate uterine contractility in a gestationally regulated fashion. The objective of this study was to determine the mechanism by which uterine caspase-3 is activated and consequently controlled in ...
Condon, Jennifer C. +5 more
core +3 more sources
Bee‐Derived Antioxidants as a Protective Strategy Against Doxorubicin‐Induced Ovarian Damage
Chemistry &Biodiversity, EarlyView.Graphical abstract of Bee‐Derived Antioxidants as a Protective Strategy Against Doxorubicin‐Induced Ovarian Damage ABSTRACT Antineoplastic agents can induce tissue damage through oxidative stress mechanisms. Doxorubicin, a widely used chemotherapeutic agent, has been shown to cause permanent damage to reproductive tissues.
Meltem Arıkan Malkoc +3 more
wiley +1 more source
Unfolding the role of stress response signaling in endocrine resistant breast cancers
Frontiers in Oncology, 2015 The unfolded protein response (UPR) is an ancient stress response that enables a cell to manage the energetic stress that accompanies protein folding.
Robert eClarke, Katherine L Cook
doaj +1 more source
tRNA ligase structure reveals kinetic competition between non-conventional mRNA splicing and mRNA decay. [PDF]
, 2019 Yeast tRNA ligase (Trl1) is an essential trifunctional enzyme that catalyzes exon-exon ligation during tRNA biogenesis and the non-conventional splicing of HAC1 mRNA during the unfolded protein response (UPR).
Peschek, Jirka, Walter, Peter
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