Results 51 to 60 of about 67,514 (293)
A crosstalk between p21 and UPR-induced transcription factor C/EBP homologous protein (chop) linked to type 2 diabetes [PDF]
, 2013 Type 2 diabetes (T2D) is a disease that is characterized by raised levels of glucose in the blood combined with insulin resistance and relative insulin deficiency.
Kiaris, Hippokratis +2 more
core +1 more source
Anti-pancreatic cancer activity of ONC212 involves the unfolded protein response (UPR) and is reduced by IGF1-R and GRP78/BIP. [PDF]
Oncotarget, 2017 Lev A +11 more
europepmc +3 more sources
International Journal of Molecular Sciences, 2023 Unfolded protein response (UPR) is an adaptive response which is used for re-establishing protein homeostasis, and it is triggered by endoplasmic reticulum (ER) stress.
Gregorio Bonsignore +2 more
semanticscholar +1 more source
Nature Communications, 2022 Endoplasmic Reticulum stress induces cell non-autonomous Unfolded Protein Response (UPR) activation. Here the authors show that long-chain ceramides are secreted from muscle cells in extracellular vesicles and induce cell non-autonomous UPR activation in
Ben D. McNally +15 more
doaj +1 more source
An unfolded protein-induced conformational switch activates mammalian IRE1. [PDF]
, 2017 The unfolded protein response (UPR) adjusts the cell's protein folding capacity in the endoplasmic reticulum (ER) according to need. IRE1 is the most conserved UPR sensor in eukaryotic cells.
Acosta-Alvear, Diego +5 more
core +3 more sources
Plants, 2022 The endoplasmic reticulum (ER), a eukaryotic organelle, is the major site of protein biosynthesis. The disturbance of ER function by biotic or abiotic stress triggers the accumulation of misfolded or unfolded proteins in the ER.
June-Sik Kim +2 more
doaj +1 more source
ER Stress, the Unfolded Protein Response and Osteoclastogenesis: A Review
Biomolecules, 2023 Endoplasmic reticulum (ER) stress and its adaptive mechanism, the unfolded protein response (UPR), are triggered by the accumulation of unfolded and misfolded proteins. During osteoclastogenesis, a large number of active proteins are synthesized. When an
Wan-fang Huang, Yining Gong, Liang Yan
semanticscholar +1 more source
Cancer microenvironment and endoplasmic reticulum stress response [PDF]
, 2015 Different stressful conditions such as hypoxia, nutrient deprivation, pH changes, or reduced vascularization, potentially able to act as growth-limiting factors for tumor cells, activate the unfolded protein response (UPR).
Conti, S +5 more
core +4 more sources
TP53 R249S mutation in hepatic organoids captures the predisposing cancer risk
Hepatology, EarlyView., 2022 The systematic approach in elucidating the gain‐of‐function (GOF) roles of TP53 mutations in early liver carcinogenesis. Unique downstream targets of TP53 L3 mutations were identified from chormatin immunoprecipitation sequencing in HCC cell lines, followed by a series of validation assays to substantiate the exclusive transcriptional regulations ...
Yin Kau Lam +10 more
wiley +1 more source
Targeting the IRE1α/XBP1s pathway suppresses CARM1-expressing ovarian cancer
Nature Communications, 2021 The unfolded protein response (UPR) promotes cell survival in cancers with hyperactive ER stress response. Here the authors show that CARM1, an arginine methyltransferase, controls the IRE1α/XBP1 pathway of the UPR and the inhibition of this pathway can ...
Jianhuang Lin +13 more
doaj +1 more source