Results 51 to 60 of about 52,959 (267)
Endoplasmic reticulum stress and liver diseases
Liver Research, 2019 Endoplasmic reticulum (ER) stress occurs when ER homeostasis is perturbed with accumulation of unfolded/misfolded protein or calcium depletion. The unfolded protein response (UPR), comprising of inositol-requiring enzyme 1α (IRE1α), double-stranded RNA ...
Xiaoying Liu, Richard M. Green
doaj +1 more source
Ethanol Effects Involve Non-canonical Unfolded Protein Response Activation in Yeast Cells [PDF]
, 2017 The unfolded protein response (UPR) is a conserved intracellular signaling pathway that controls transcription of endoplasmic reticulum (ER) homeostasis related genes.
Navarro Tapia, Elisabet +2 more
core +1 more source
Plants, 2022 The endoplasmic reticulum (ER), a eukaryotic organelle, is the major site of protein biosynthesis. The disturbance of ER function by biotic or abiotic stress triggers the accumulation of misfolded or unfolded proteins in the ER.
June-Sik Kim +2 more
doaj +1 more source
eLife, 2015 The unfolded protein response (UPR) is an essential cell signaling system that detects the accumulation of misfolded proteins within the endoplasmic reticulum (ER) and initiates a cellular response in order to maintain homeostasis.
Marta Carrara +4 more
doaj +1 more source
ER Stress and Unfolded Protein Response in Leukemia: Friend, Foe, or Both?
Biomolecules, 2021 The unfolded protein response (UPR) is an evolutionarily conserved adaptive signaling pathway triggered by a stress of the endoplasmic reticulum (ER) lumen compartment, which is initiated by the accumulation of unfolded proteins.
Kelly Féral +7 more
doaj +1 more source
A crosstalk between p21 and UPR-induced transcription factor C/EBP homologous protein (chop) linked to type 2 diabetes [PDF]
, 2013 Type 2 diabetes (T2D) is a disease that is characterized by raised levels of glucose in the blood combined with insulin resistance and relative insulin deficiency.
Kiaris, Hippokratis +2 more
core +1 more source
Cancer microenvironment and endoplasmic reticulum stress response [PDF]
, 2015 Different stressful conditions such as hypoxia, nutrient deprivation, pH changes, or reduced vascularization, potentially able to act as growth-limiting factors for tumor cells, activate the unfolded protein response (UPR).
Conti, S +5 more
core +4 more sources
Using Arabidopsis Mesophyll Protoplasts to Study Unfolded Protein Response Signaling
Bio-Protocol, 2018 Various environmental stresses or artificial reagents can trigger unfolded protein accumulation in the endoplasmic reticulum (ER) due to the folding capacity of the ER being exceeded.
Yan Bao, Diane Bassham
doaj +1 more source
Control of mammalian brain aging by the unfolded protein response (UPR) [PDF]
, 2020 AbstractAging is the major risk factor for the development of dementia and neurodegenerative disorders, and the aging brain manifests severe deficits in buffering capacity by the proteostasis network. Accordingly, we investigated the significance of the unfolded protein response (UPR), a major signaling pathway that copes with endoplasmic reticulum (ER)
Cabral-Miranda, Felipe +23 more
openaire +1 more source
BLISTER-regulated vegetative growth is dependent on the protein kinase domain of ER stress modulator IRE1A in Arabidopsis thaliana [PDF]
, 2019 The unfolded protein response (UPR) is required for protein homeostasis in the endoplasmic reticulum (ER) when plants are challenged by adverse environmental conditions.
Hong, Zheng-Hui +4 more
core +1 more source