The Unfolded Protein Response and its potential role in Huntington's disease [PDF]
, 2012 Huntington's disease (HD) is a progressive, neurodegenerative disease with fatal outcome. Although the disease-causing gene (huntingtin) has been known for some time, the exact cause of neuronal cell death is still unknown.
Kamesh Ayasolla +2 more
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Interplay between endoplasmic reticulum (ER) stress and autophagy induces mutant p53H273 degradation [PDF]
, 2020 The unfolded protein response (UPR) is an adaptive response to intrinsic and external stressors, and it is mainly activated by the accumulation of misfolded proteins at the endoplasmic reticulum (ER) lumen producing ER stress.
Cirone, Mara +5 more
core +1 more source
A small molecule UPR modulator for diabetes identified by high throughput screening
Acta Pharmaceutica Sinica B, 2021 Unfolded protein response (UPR) is a stress response that is specific to the endoplasmic reticulum (ER). UPR is activated upon accumulation of unfolded (or misfolded) proteins in the ER's lumen to restore protein folding capacity by increasing the ...
Valeria Marrocco +15 more
doaj
Using Arabidopsis Mesophyll Protoplasts to Study Unfolded Protein Response Signaling
Bio-Protocol, 2018 Various environmental stresses or artificial reagents can trigger unfolded protein accumulation in the endoplasmic reticulum (ER) due to the folding capacity of the ER being exceeded.
Yan Bao, Diane Bassham
doaj +1 more source
Endoplasmic Reticulum Stress and Unfolded Protein Response Signaling in Plants
International Journal of Molecular Sciences, 2022 Plants are sensitive to a variety of stresses that cause various diseases throughout their life cycle. However, they have the ability to cope with these stresses using different defense mechanisms.
Hakim Manghwar, Jianming Li
semanticscholar +1 more source
Next-generation proteasome inhibitor oprozomib synergizes with modulators of the unfolded protein response to suppress hepatocellular carcinoma [PDF]
, 2016 Hepatocellular carcinoma (HCC) responds poorly to conventional systemic therapies. The first-in-class proteasome inhibitor bortezomib has been approved in clinical use for hematologic malignancies and has shown modest activity in solid tumors, including ...
Bogaerts, Eliene +12 more
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Ethanol Effects Involve Non-canonical Unfolded Protein Response Activation in Yeast Cells [PDF]
, 2017 The unfolded protein response (UPR) is a conserved intracellular signaling pathway that controls transcription of endoplasmic reticulum (ER) homeostasis related genes.
Navarro Tapia, Elisabet +2 more
core +1 more source
Crystal structures reveal transient
, 2015 Stress caused by accumulation of misfolded proteins within the endoplasmic reticulum (ER) elicits a cellular unfolded protein response (UPR) aimed at maintaining protein-folding capacity.
Ali, Maruf MU +3 more
core +1 more source
Insight into the mitochondrial unfolded protein response and cancer: opportunities and challenges
Cell & Bioscience, 2022 The mitochondrial unfolded protein response (UPR mt ) is an evolutionarily conserved protective transcriptional response that maintains mitochondrial proteostasis by inducing the expression of mitochondrial chaperones and proteases in response to various
Ge Wang, Yumei Fan, P. Cao, K. Tan
semanticscholar +1 more source
BLISTER-regulated vegetative growth is dependent on the protein kinase domain of ER stress modulator IRE1A in Arabidopsis thaliana [PDF]
, 2019 The unfolded protein response (UPR) is required for protein homeostasis in the endoplasmic reticulum (ER) when plants are challenged by adverse environmental conditions.
Hong, Zheng-Hui +4 more
core +1 more source