Results 71 to 80 of about 67,514 (293)

A multi-omics analysis reveals the unfolded protein response regulon and stress-induced resistance to folate-based antimetabolites

Nature Communications, 2020
The unfolded protein response (UPR) is a stress response pathway implicated in numerous diseases and chemotherapy resistance. Here, the authors define the UPR regulon with a multi-omics strategy, uncovering changes to mitochondrial one-carbon metabolism ...
Stefan Reich, Chi D. L. Nguyen, Canan Has, Sascha Steltgens, Himanshu Soni, Cristina Coman, Moritz Freyberg, Anna Bichler, Nicole Seifert, Dominik Conrad, Christiane B. Knobbe-Thomsen, Björn Tews, Grischa Toedt, Robert Ahrends, Jan Medenbach   +14 more
doaj   +1 more source

The Impact of Endoplasmic Reticulum-Associated Protein Modifications, Folding and Degradation on Lung Structure and Function

Frontiers in Physiology, 2021
The accumulation of unfolded/misfolded proteins in the endoplasmic reticulum (ER) causes ER stress and induces the unfolded protein response (UPR) and other mechanisms to restore ER homeostasis, including translational shutdown, increased targeting of ...
Emily M. Nakada, Emily M. Nakada, Rui Sun, Rui Sun, Utako Fujii, Utako Fujii, James G. Martin, James G. Martin   +7 more
doaj   +1 more source

Regulation of lipid metabolism by the unfolded protein response

Journal of Cellular and Molecular Medicine, 2021
The endoplasmic reticulum (ER) is the site of protein folding and secretion, Ca2+ storage and lipid synthesis in eukaryotic cells. Disruption to protein folding or Ca2+ homeostasis in the ER leads to the accumulation of unfolded proteins, a condition ...
Matthieu Moncan, K. Mnich, A. Blomme, Aitor Almanza, Afshin Samali, A. Gorman   +5 more
semanticscholar   +1 more source

Potential for therapeutic manipulation of the UPR in disease [PDF]

, 2013
Increased endoplasmic reticulum (ER) stress and the activated unfolded protein response (UPR) signaling associated with it play key roles in physiological processes as well as under pathological conditions.
Ozcan, Umut, Park, Sang Won
core   +2 more sources

Manipulation of the unfolded protein response: A pharmacological strategy against coronavirus infection

PLoS Pathogens, 2021
Coronavirus infection induces the unfolded protein response (UPR), a cellular signalling pathway composed of three branches, triggered by unfolded proteins in the endoplasmic reticulum (ER) due to high ER load.
Liliana Echavarría-Consuegra, Georgia M Cook, I. Busnadiego, Charlotte Lefèvre, Sarah Keep, Katherine Brown, Nicole Doyle, Giulia Dowgier, Krzysztof Franaszek, Nathan A Moore, S. Siddell, Erica Bickerton, B. G. Hale, A. Firth, I. Brierley, N. Irigoyen   +15 more
semanticscholar   +1 more source

A mechanism of ineffective erythropoiesis in β-thalassemia/Hb E disease

Haematologica, 2010
Background Cells respond to stress stimuli through a number of response pathways, of which one of the most important and well characterized is the unfolded protein response.
Pathrapol Lithanatudom, Amporn Leecharoenkiat, Tirawat Wannatung, Saovaros Svasti, Suthat Fucharoen, Duncan R. Smith   +5 more
doaj   +1 more source

The virulence of the opportunistic fungal pathogen Aspergillus fumigatus requires cooperation between the endoplasmic reticulum-associated degradation pathway (ERAD) and the unfolded protein response (UPR)

Virulence, 2011
The filamentous fungal pathogen Aspergillus fumigatus secretes hydrolytic enzymes to acquire nutrients from host tissues. The production of these enzymes exerts stress on the endoplasmic reticulum (ER), which is alleviated by two stress responses: the ...
Daryl L Richie, Xizhi Feng, Lukas Hartl, V. Aimanianda, K. Krishnan, Margaret V. Powers-Fletcher, Doug Watson, A. Galande, Stephanie M White, Taryn T. Willett, J. Latgé, J. C. Rhodes, D. Askew   +12 more
semanticscholar   +1 more source

Engineering of the unfolded protein response pathway in Pichia pastoris: enhancing production of secreted recombinant proteins

Applied Microbiology and Biotechnology, 2021
Folding and processing of proteins in the endoplasmic reticulum (ER) are major impediments in the production and secretion of proteins from Pichia pastoris (Komagataella sp.).
Hana Raschmanová, A. Weninger, Z. Knejzlík, K. Melzoch, K. Kovar   +4 more
semanticscholar   +1 more source

Unfolded protein response in cancer: the Physician's perspective

Journal of Hematology & Oncology, 2011
The unfolded protein response (UPR) is a cascade of intracellular stress signaling events in response to an accumulation of unfolded or misfolded proteins in the lumen of the endoplasmic reticulum (ER). Cancer cells are often exposed to hypoxia, nutrient
Li Zihai, Zhang Kezhong, Li Xuemei
doaj   +1 more source

Dicarbonyl stress, protein glycation and the unfolded protein response

Glycoconjugate Journal, 2021
The reactive dicarbonyl metabolite, methylglyoxal (MG), is increased in obesity and diabetes and is implicated in the development of insulin resistance, type 2 diabetes mellitus and vascular complications of diabetes.
N. Rabbani, M. Xue, Paul J Thornalley
semanticscholar   +1 more source