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Universal influenza vaccines: from viruses to nanoparticles [PDF]
Expert Review of Vaccines, 2018 Introduction: The current seasonal influenza vaccine confers only limited protection due to waning antibodies or the antigenic shift and drift of major influenza surface antigens. A universal influenza vaccine which induces broad cross-protection against
Ye Wang +3 more
doaj +3 more sources
The Hurdles From Bench to Bedside in the Realization and Implementation of a Universal Influenza Vaccine [PDF]
Frontiers in Immunology, 2018 Influenza viruses circulate worldwide causing annual epidemics that have a substantial impact on public health. This is despite vaccines being in use for over 70 years and currently being administered to around 500 million people each year.
Sophie A. Valkenburg +9 more
doaj +2 more sources
Options and Obstacles for Designing a Universal Influenza Vaccine [PDF]
Viruses, 2014 Since the discovery of antibodies specific to a highly conserved stalk region of the influenza virus hemagglutinin (HA), eliciting such antibodies has been considered the key to developing a universal influenza vaccine that confers broad-spectrum ...
Yo Han Jang, Baik Lin Seong
doaj +2 more sources
Biomimetic nanoparticles as universal influenza vaccine. [PDF]
Smart Mater Med, 2020 Pandemic virus infections pose a major public health threat globally. Much efforts have been devoted to suppress the virus, including vaccine prevention, autoimmunity enhancement, and anti-virus drugs treatment. Among these strategies, development of novel and improved vaccine technologies attracts broad attention as they can nip the virus outbreak in ...
Wang F, Chen G, Zhao Y.
europepmc +4 more sources
Is It Possible? A Different Approach to Creating a Universal Influenza Vaccine [PDF]
mBio, 2015 The best way to combat influenza virus infection is to prevent it. However, the continual evolution of circulating influenza virus strains and the constant threat of newly emerging viruses forces the public health community to annually update seasonal ...
Stacey Schultz-Cherry
doaj +2 more sources
Influenza Vaccine Effectiveness and Progress Towards a Universal Influenza Vaccine. [PDF]
DrugsAt various times in recent decades, surges have occurred in optimism about the potential for universal influenza vaccines that provide strong, broad, and long-lasting protection and could substantially reduce the disease burden associated with seasonal influenza epidemics as well as the threat posed by pandemic influenza.
Cowling BJ, Okoli GN.
europepmc +3 more sources
Targeting Antigens for Universal Influenza Vaccine Development. [PDF]
Viruses, 2021 Traditional influenza vaccines generate strain-specific antibodies which cannot provide protection against divergent influenza virus strains. Further, due to frequent antigenic shifts and drift of influenza viruses, annual reformulation and revaccination are required in order to match circulating strains.
Nguyen QT, Choi YK.
europepmc +5 more sources
Development of a Universal Influenza Vaccine. [PDF]
J Immunol, 2019 Abstract The severity of the 2017–18 influenza season, combined with the low efficacy for some vaccine components, highlights the need to improve our current seasonal influenza vaccine. Thus, the National Institute of Allergy and Infectious Diseases recently announced a strategic plan to improve current influenza vaccines and eventually ...
Estrada LD, Schultz-Cherry S.
europepmc +4 more sources
Influenza nucleoprotein delivered with aluminium salts protects mice from an influenza virus that expresses an altered nucleoprotein sequence [PDF]
, 2013 Influenza virus poses a difficult challenge for protective immunity. This virus is adept at altering its surface proteins, the proteins that are the targets of neutralizing antibody.
A Endo +51 more
core +11 more sources
Universal influenza vaccines: Shifting to better vaccines [PDF]
Vaccine, 2016 Influenza virus causes acute upper and lower respiratory infections and is the most likely, among known pathogens, to cause a large epidemic in humans. Influenza virus mutates rapidly, enabling it to evade natural and vaccine-induced immunity. Furthermore, influenza viruses can cross from animals to humans, generating novel, potentially pandemic ...
Berlanda Scorza, Francesco +2 more
openaire +2 more sources