Results 21 to 30 of about 50,051 (221)
M2e-Based Universal Influenza A Vaccines [PDF]
Vaccines, 2015 The successful isolation of a human influenza virus in 1933 was soon followed by the first attempts to develop an influenza vaccine. Nowadays, vaccination is still the most effective method to prevent human influenza disease. However, licensed influenza vaccines offer protection against antigenically matching viruses, and the composition of these ...
Lei Deng +3 more
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Influenza Vaccines toward Universality through Nanoplatforms and Given by Microneedle Patches
Viruses, 2020 Influenza is one of the top threats to public health. The best strategy to prevent influenza is vaccination. Because of the antigenic changes in the major surface antigens of influenza viruses, current seasonal influenza vaccines need to be updated every
Sijia Tang, Wandi Zhu, Bao-Zhong Wang
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Recent Progress in Recombinant Influenza Vaccine Development Toward Heterosubtypic Immune Response
Frontiers in Immunology, 2022 Flu, a viral infection caused by the influenza virus, is still a global public health concern with potential to cause seasonal epidemics and pandemics. Vaccination is considered the most effective protective strategy against the infection. However, given
Mark B. Carascal +3 more
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Towards universal influenza vaccines? [PDF]
Philosophical Transactions of the Royal Society B: Biological Sciences, 2011 Vaccination is the most cost-effective way to reduce the considerable disease burden of seasonal influenza. Although seasonal influenza vaccines are effective, their performance in the elderly and immunocompromised individuals would benefit from improvement.
A. Osterhaus +2 more
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Broadly Protective Strategies Against Influenza Viruses: Universal Vaccines and Therapeutics
Frontiers in Microbiology, 2020 Influenza virus is a respiratory pathogen that can cause disease in humans, with symptoms ranging from mild to life-threatening. The vast majority of influenza virus infections in humans are observed during seasonal epidemics and occasional pandemics ...
Olivia A. Vogel, Balaji Manicassamy
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Hemagglutinin sequence conservation guided stem immunogen design from influenza A H3 subtype [PDF]
, 2015 Seasonal epidemics caused by influenza A (H1 and H3 subtypes) and B viruses are a major global health threat. The traditional, trivalent influenza vaccines have limited efficacy because of rapid antigenic evolution of the circulating viruses.
Citron, Michael +6 more
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Viruses, 2020 On average, there are 3–5 million severe cases of influenza virus infections globally each year. Seasonal influenza vaccines provide limited protection against divergent influenza strains.
Brigette N. Corder +3 more
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Universal Flu mRNA Vaccine: Promises, Prospects, and Problems
Vaccines, 2022 The seasonal flu vaccine is, essentially, the only known way to prevent influenza epidemics. However, this approach has limited efficacy due to the high diversity of influenza viruses. Several techniques could potentially overcome this obstacle. A recent
Andrei A. Deviatkin +5 more
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Prospects and Challenges in the Development of Universal Influenza Vaccines
Vaccines, 2020 Current influenza vaccines offer suboptimal protection and depend on annual reformulation and yearly administration. Vaccine technology has rapidly advanced during the last decade, facilitating development of next-generation influenza vaccines that can ...
Anders Madsen, Rebecca Jane Cox
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Nano/microparticle Formulations for Universal Influenza Vaccines [PDF]
The AAPS Journal, 2022 Influenza affects millions of people worldwide and can result in severe sickness and even death. The best method of prevention is vaccination; however, the seasonal influenza vaccine often suffers from low efficacy and requires yearly vaccination due to changes in strain and viral mutations.
Dylan A. Hendy +4 more
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