Results 51 to 60 of about 50,051 (221)

Strategies towards universal pandemic influenza vaccines

Expert Review of Vaccines, 2015
Vaccination is considered to be the most effective and economical strategy against pandemic influenza. Vaccine development for multiple highly pathogenic avian influenza viruses, for example, H5N1, is hindered by antigenic drift, especially in the hemagglutinin (HA) sequence, as well as the antigenic shift.
Fang, He, Sonja, Leyrer, Jimmy, Kwang
openaire   +2 more sources

Summertime, and the livin is easy: Winter and summer pseudoseasonal life expectancy in the United States [PDF]

, 2017
In temperate climates, mortality is seasonal with a winter-dominant pattern, due in part to pneumonia and influenza. Cardiac causes, which are the leading cause of death in the United States, are also winter-seasonal although it is not clear why ...
Ho, Tina, Noymer, Andrew
core   +2 more sources

A Universal Influenza Virus Vaccine Candidate Tested in a Pig Vaccination-Infection Model in the Presence of Maternal Antibodies

Vaccines, 2018
The antigenically conserved hemagglutinin stalk region is a target for universal influenza virus vaccines since antibodies against it can provide broad protection against influenza viruses of different subtypes.
Sun-Young Sunwoo, Michael Schotsaert, Igor Morozov, Anne Sally Davis, Yuhao Li, Jinhwa Lee, Chester McDowell, Philip Meade, Raffael Nachbagauer, Adolfo García-Sastre, Wenjun Ma, Florian Krammer, Juergen A. Richt   +12 more
doaj   +1 more source

Chemical-free inactivated whole influenza virus vaccine prepared by ultrashort pulsed laser treatment [PDF]

, 2014
There is an urgent need for rapid methods to develop vaccines in response to emerging viral pathogens. Whole inactivated virus (WIV) vaccines represent an ideal strategy for this purpose; however, a universal method for producing safe and immunogenic ...
Achilefu, Samuel, Chen, Alexander, Donthi, Nisha, Hsieh, Wen-Han, Hung, Chien-Fu, Knoff, Jayne, La, Victor, Li, Yen-Der, Tsen, Kong-Thon, Tsen, Shaw-Wei David, Wu, Tzyy-Choou   +10 more
core   +2 more sources

Prospects for Universal Influenza Virus Vaccine

Emerging Infectious Diseases, 2006
The current vaccination strategy against influenza A and B viruses is vulnerable to the unanticipated emergence of epidemic strains that are poorly matched by the vaccine. A vaccine that is less sensitive to the antigenic evolution of the virus would be a major improvement.
Walter Gerhard, Krystyna Mozdzanowska, Darya Zharikova   +2 more
openaire   +3 more sources

Universal Live-Attenuated Influenza Vaccine Candidates Expressing Multiple M2e Epitopes Protect Ferrets against a High-Dose Heterologous Virus Challenge

Viruses, 2021
The development of an influenza vaccine with broad protection and durability remains an attractive idea due to the high mutation rate of the influenza virus.
Daria Mezhenskaya, Irina Isakova-Sivak, Victoria Matyushenko, Svetlana Donina, Andrey Rekstin, Konstantin Sivak, Kirill Yakovlev, Anastasia Katelnikova, Kirill Kryshen, Valery Makarov, Larisa Rudenko   +10 more
doaj   +1 more source

A human multi-epitope recombinant vaccinia virus as a universal T cell vaccine candidate against influenza virus. [PDF]

PLoS ONE, 2011
There is a need to develop a universal vaccine against influenza virus infection to avoid developing new formulations of a seasonal vaccine each year. Many of the vaccine strategies for a universal vaccine target strain-conserved influenza virus proteins,
Alan G Goodman, Paul P Heinen, Susana Guerra, Aneesh Vijayan, Carlos Oscar S Sorzano, Carmen E Gomez, Mariano Esteban   +6 more
doaj   +1 more source

Influenza Evolution and H3N2 Vaccine Effectiveness, with Application to the 2014/2015 Season [PDF]

, 2016
Influenza A is a serious disease that causes significant morbidity and mortality, and vaccines against the seasonal influenza disease are of variable effectiveness.
Deem, Michael W., Li, Xi
core   +2 more sources

Intrinsically Disordered Protein‐Inspired Nanovector‐Based Coacervates for the Direct Cytosolic Transport of Biomacromolecules

Advanced Materials, EarlyView.
Intrinsically disordered protein‐inspired nanovectors (IDP‐NVs) form stable nanocoacervates (NCs) with diverse biomacromolecules. In situ conformational changes confer stability and adaptability to NCs under dynamically changing physiological conditions.
Soyeong Jin, Hyemin Park, Seuk‐Min Ryu, Dagyeong Guk, Jaeeun Lee, Seongeon Jin, Changjoon Keum, Jinyoung Park, Myoung‐Hwan Park, Chaekyu Kim, Hojun Kim, Jaegeun Noh, Kwan Hyi Lee, Ja‐Hyoung Ryu, Youngdo Jeong   +14 more
wiley   +1 more source

Evaluation of the impact of immunization policies, including the addition of pharmacists as immunizers, on influenza vaccination coverage in Nova Scotia, Canada: 2006 to 2016

BMC Public Health, 2018
Background Influenza is a serious public health concern, resulting in morbidity, mortality and significant expense to healthcare systems worldwide. Annual vaccination is the most effective way to prevent influenza.
Jennifer E. Isenor, Beth A. O’Reilly, Susan K. Bowles   +2 more
doaj   +1 more source