Results 51 to 60 of about 42,982 (161)

Metabolomics-Based Screening of Inborn Errors of Metabolism: Enhancing Clinical Application with a Robust Computational Pipeline

Metabolites, 2021
Inborn errors of metabolism (IEM) are inherited conditions caused by genetic defects in enzymes or cofactors. These defects result in a specific metabolic fingerprint in patient body fluids, showing accumulation of substrate or lack of an end-product of ...
Brechtje Hoegen, Alan Zammit, Albert Gerritsen, Udo F. H. Engelke, Steven Castelein, Maartje van de Vorst, Leo A. J. Kluijtmans, Marleen C. D. G. Huigen, Ron A. Wevers, Alain J. van Gool, Christian Gilissen, Karlien L. M. Coene, Purva Kulkarni   +12 more
doaj   +1 more source

Metabolomics: a review of liquid chromatography mass spectrometry-based methods and clinical applications

Türk Biyokimya Dergisi
Metabolomics is a rapidly growing field that aims to understand the complex metabolic pathways involved in health and disease. Liquid chromatography mass spectrometry (LC-MS) based untargeted metabolomics has emerged as a powerful tool for investigating ...
Doğan Halef Okan
doaj   +1 more source

Effective data visualization strategies in untargeted metabolomics [PDF]

LC-MS/MS-based untargeted metabolomics is a rapidly developing research field spawning increasing numbers of computational metabolomics tools assisting researchers with their complex data processing, analysis, and interpretation tasks.
Koetsier, Robert A., Ehlers, Henry, van der Hooft, Justin J. J., Mildau, Kevin, de Jonge, Niek F., Torres Ortega, Laura Rosina, Tugizimana, Fidele, Singh, Kumar Saurabh, Del Pup, Elena, Meisenburg, Mara, Ferreira, Dora, Othibeng, Kgalaletso, Huber, Florian   +12 more
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Automated Sequential Analysis of Hydrophilic and Lipophilic Fractions of Biological Samples : Increasing Single-Injection Chemical Coverage in Untargeted Metabolomics [PDF]

, 2021
In order to increase metabolite coverage in LC-MS-based untargeted metabolomics, HILIC- and RPLC-mode separations are often combined. Unfortunately, these two techniques pose opposite requirements on sample composition, necessitating either dual sample ...
Curt Pettersson, Laurell, Göran,, Kristian Pirttilä, Pettersson, Curt,, Göran Laurell, Pirttilä, Kristian, Laurell, Göran, Hedeland, Mikael,, Mikael Hedeland, Pettersson, Curt, Hedeland, Mikael, Pirttilä, Kristian,   +11 more
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Analysis of potential biomarkers for diabetic kidney disease and non-diabetic kidney disease based on urinary metabolomics analysis

BMC Nephrology
Background Diabetic kidney disease (DKD) is a leading cause of chronic renal failure. However, not all patients with type 2 diabetes mellitus (T2DM) develop DKD.
Qiuyue He, Binbin Ye, Huanqin Li, Yuqing Pan, Yan Du, Kai Yang   +5 more
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488 From discovery to the clinical laboratory: a methodological appraisal of untargeted metabolomics platforms to characterize inborn errors of metabolism.

Journal of Clinical and Translational Science
OBJECTIVES/GOALS: Untargeted metabolomics platforms are powerful biomarker discovery tools. However, the absence of uniform study design, data analysis, and reporting standards limits translation of this research into the clinical lab.
Rachel Wurth, Coleman Turgeon, Zinandré Stander, Devin Oglesbee   +3 more
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Metabolomics and wood development [PDF]

, 2013
The tree industry is one of Sweden's most important economic sectors, producing pulp, paper, wooden goods and wood as a bioenergy source. Understanding the biology behind the processes of tree growth and wood development is a key to maximizing the use of
Johansson, Annika I.
core  

ZF Kidney Untargeted Metabolomics in High Calorie Diet - Supplemental Material [PDF]

, 2023
Supplemental material for publication on untargeted metabolomics in a zebrafish model of obesity related kidney disease.
Evan Zeitler (11998577), Ronald Falk (15369173), Yuanyuan Li (15369178), Susan Sumner (15369177)   +3 more
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The Metabolic and Lipidomic Fingerprint of Torin1 Exposure in Mouse Embryonic Fibroblasts Using Untargeted Metabolomics [PDF]

Torin1, a selective kinase inhibitor targeting the mammalian target of rapamycin (mTOR), remains widely used in autophagy research due to its potent autophagy-inducing abilities, regardless of its unspecific properties.
Katyeny Manuela da Silva, Sigrid Stroobants, Elias Iturrospe, Maria van de Lavoir, Alexander L. N. van Nuijs, Adrian Covaci, Vincent Timmerman, Rani Robeyns, Angela Sisto   +8 more
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Targeted and untargeted metabolomics uncovering the effects of Jiawei Ermiao Granule on patients with persistent HPV infection

Frontiers in Cellular and Infection Microbiology
Jiawei Ermiao Granule (JWEMG) is a traditional Chinese herbal formulation widely used in China for the treatment of human papilloma virus (HPV) infections. However, the mechanisms underlying their efficacy in clearing HPV infections remain unclear.
Xiu Li, Xiu Li, Li Ning, Li Ning, Hongting Zhao, Yating Xu, Yating Xu, Yu Si, Yu Si, Jiayi Hua, Qingling Ren, Qingling Ren   +11 more
doaj   +1 more source