Results 51 to 60 of about 124,046 (257)

Cobalt Single‐Atom Nanozyme for Enhanced Intestinal Radioprotection and Tumor Radiosensitization via Bidirectional ROS Modulation

Advanced Science, EarlyView.
Orally administered, pH‐responsive Co‐SAN exerts dual functions: in the alkaline intestinal milieu, it scavenges reactive oxygen species (ROS) and suppresses the PI3K/AKT pathway and NETs formation, thus providing radioprotection; whereas in the acidic tumor microenvironment, it generates ROS and alleviates hypoxia, thereby enhancing radiosensitization.
Shengqi Yin, Junjie Li, Yishu Zou, Yang Liu, Yilin Zheng, Lu Yu, Wanying Zheng, Yajun Zou, Zehui Zhang, Tao Li, Peiqun Yin, Jianlin Zhang, Yuen Wu, Yi Ding   +13 more
wiley   +1 more source

untargeted metabolomics data

Untargeted metabolomics study.
Karolina Kaźmierczak-Siedlecka (18430263)
core   +2 more sources

Analysis of potential biomarkers for diabetic kidney disease and non-diabetic kidney disease based on urinary metabolomics analysis

BMC Nephrology
Background Diabetic kidney disease (DKD) is a leading cause of chronic renal failure. However, not all patients with type 2 diabetes mellitus (T2DM) develop DKD.
Qiuyue He, Binbin Ye, Huanqin Li, Yuqing Pan, Yan Du, Kai Yang   +5 more
doaj   +1 more source

488 From discovery to the clinical laboratory: a methodological appraisal of untargeted metabolomics platforms to characterize inborn errors of metabolism.

Journal of Clinical and Translational Science
OBJECTIVES/GOALS: Untargeted metabolomics platforms are powerful biomarker discovery tools. However, the absence of uniform study design, data analysis, and reporting standards limits translation of this research into the clinical lab.
Rachel Wurth, Coleman Turgeon, Zinandré Stander, Devin Oglesbee   +3 more
doaj   +1 more source

Metabolomics-Based Screening of Inborn Errors of Metabolism: Enhancing Clinical Application with a Robust Computational Pipeline

Metabolites, 2021
Inborn errors of metabolism (IEM) are inherited conditions caused by genetic defects in enzymes or cofactors. These defects result in a specific metabolic fingerprint in patient body fluids, showing accumulation of substrate or lack of an end-product of ...
Brechtje Hoegen, Alan Zammit, Albert Gerritsen, Udo F. H. Engelke, Steven Castelein, Maartje van de Vorst, Leo A. J. Kluijtmans, Marleen C. D. G. Huigen, Ron A. Wevers, Alain J. van Gool, Christian Gilissen, Karlien L. M. Coene, Purva Kulkarni   +12 more
doaj   +1 more source

HMGCR‐Driven Cholesterol Metabolism Promotes Osteoarthritis Progression by Accelerating Synovial Fibroblast Senescence

Advanced Science, EarlyView.
In the pathological context of osteoarthritis (OA), the phosphorylation of AKT1 at Ser473 enhances its binding to Lys140 of Insig1, which facilitates the formation of AKT1–Insig1 complex. Subsequently, the activation of AKT1 promotes the phosphorylation of Insig1 at Ser189, potentially enhancing the dissociation of Insig1 from sterol regulatory element‑
Xiaoqi Zhang, Siru Zhou, Xi Liu, Wei Xiang, Xiuqin Peng, Yu Tian, Song Li, Hailin Wang, Bo Liao, Shunzheng Fang, Runze Jin, Jinhui Wu, Chuanqing Bai, Wei Zhang, Bo Huang, Bingfei Li, Lifeng Chen, Lin Chen, Bin Zhang, Zhenhong Ni   +19 more
wiley   +1 more source

Automated Signal Processing Applied to Volatile-Based Inspection of Greenhouse Crops [PDF]

, 2010
Gas chromatograph–mass spectrometers (GC-MS) have been used and shown utility for volatile-based inspection of greenhouse crops. However, a widely recognized difficulty associated with GC-MS application is the large and complex data generated by this ...
Roel Jansen, van Henten, E.J., Bouwmeester, H.J., Eldert van Henten, Jansen, R.M.C., Hofstee, J.W., Harro Bouwmeester, Jan Willem Hofstee, Henten, E.J., van   +8 more
core   +1 more source

Intermittent Fasting Restores Cardiac Lipid Homeostasis in Diabetic Cardiomyopathy in Association With Akkermansia Muciniphila and 1‐methyl‐L‐histidine

Advanced Science, EarlyView.
Intermittent fasting reshapes the gut microbiota in diabetic cardiomyopathy, restoring Akkermansia muciniphila and the microbiota‐associated metabolite 1‐methyl‐L‐histidine. This shift is linked to improved cardiac lipid homeostasis, reduced lipid peroxidation, and attenuated myocardial injury, highlighting a gut microbiota–metabolite–lipid axis in ...
Kaiyuan Jiang, Fen Xiong, Yiwen Peng, Lingfei Meng, Xinran Wang, Yingruo Xu, Tian Tang, Hongchang Gao   +7 more
wiley   +1 more source

Establishing a framework for best practices for quality assurance and quality control in untargeted metabolomics.

, 2023
BackgroundQuality assurance (QA) and quality control (QC) practices are key tenets that facilitate study and data quality across all applications of untargeted metabolomics. These important practices will strengthen this field and accelerate its success.
Kuligowski, Julia, Wilson, Ian D, Ulmer Holland, Candice Z, Vuckovic, Dajana, Theodoridis, Georgios, Lewis, Matthew R, Beecher, Chris W, Dunn, Warwick B, Mosley, Jonathan D, Zanetti, Krista A, Schock, Tracey B   +10 more
core   +1 more source

Targeted and untargeted metabolomics uncovering the effects of Jiawei Ermiao Granule on patients with persistent HPV infection

Frontiers in Cellular and Infection Microbiology
Jiawei Ermiao Granule (JWEMG) is a traditional Chinese herbal formulation widely used in China for the treatment of human papilloma virus (HPV) infections. However, the mechanisms underlying their efficacy in clearing HPV infections remain unclear.
Xiu Li, Xiu Li, Li Ning, Li Ning, Hongting Zhao, Yating Xu, Yating Xu, Yu Si, Yu Si, Jiayi Hua, Qingling Ren, Qingling Ren   +11 more
doaj   +1 more source