Results 31 to 40 of about 56,044 (294)

Untargeted lipidomic features associated with colorectal cancer in a prospective cohort. [PDF]

, 2018
BackgroundEpidemiologists are beginning to employ metabolomics and lipidomics with archived blood from incident cases and controls to discover causes of cancer.
Cai, Xiaoming, Dudoit, Sandrine, Edmands, William MB, Grigoryan, Hasmik, Gunter, Marc J, Naccarati, Alessio, Perttula, Kelsi, Petrick, Lauren, Polidoro, Silvia, Rappaport, Stephen M, Schiffman, Courtney, Vineis, Paolo   +11 more
core   +3 more sources

GARANTIA DE QUALIDADE EM METABOLÔMICA NÃO-ALVO [PDF]

Química Nova
Over the last two decades, metabolomics has emerged as a pivotal tool in multidisciplinary research, providing invaluable insights into metabolome modulations and finding applications across various scientific domains, including medicine and agronomy ...
Andrew M. Teixeira, Julia Maia Galvão de Queiroz, Bruno C. Garrido, Antônio Jorge R. Silva, Anelize Bauermeister, Ricardo M. Borges   +5 more
doaj   +1 more source

Mechanistic Insights into the Metabolic Pathways Using High-Resolution Mass Spectrometry and Predictive Models in Pancreatic β-Cell Lines (β-TC-6)

Biology and Life Sciences Forum, 2023
Objectives: We have previously shown that inhibition of the mTORC1 nutrient-sensing complex by rapamycin and mTORC1/mTORC2 inhibition by either Torin-2 or RapaLink-1 have differential effects on the global untargeted metabolomics in in vivo and in vitro ...
Ghada A. Soliman, Ye He, Rinat Abzalimov
doaj   +1 more source

Metabolomic analysis of human oral cancer cells with adenylate kinase 2 or phosphorylate glycerol kinase 1 inhibition. [PDF]

, 2017
The purpose of this study was to use liquid chromatography-mass spectrometry (LC-MS) with XCMS for a quantitative metabolomic analysis of UM1 and UM2 oral cancer cells after knockdown of metabolic enzyme adenylate kinase 2 (AK2) or phosphorylate glycerol
Cheng, Siliangyu, Cui, Li, Hu, Shen, Ji, Eoon Hye, Messadi, Diana, Yan, Xinmin, Yuan, Xiaoqing   +6 more
core   +1 more source

Making It Last: Storage Time and Temperature Have Differential Impacts on Metabolite Profiles of Airway Samples from Cystic Fibrosis Patients. [PDF]

, 2017
Metabolites of human or microbial origin have the potential to be important biomarkers of the disease state in cystic fibrosis (CF). Clinical sample collection and storage conditions may impact metabolite abundances with clinical relevance.
John J. LiPuma, Katrine Whiteson, Lisa Carmody, Peter J. Turnbaugh, Stephen Wandro, Tara Gallagher   +5 more
core   +3 more sources

Metabolomics guides rational development of a simplified cell culture medium for drug screening against Trypanosoma brucei [PDF]

, 2013
n vitro culture methods underpin many experimental approaches to biology and drug discovery. The modification of established cell culture methods to make them more biologically relevant or to optimize growth is traditionally a laborious task.
Alsford, Alsford, Baltz, Barrett, Berger, Berger, Bitonti, Bowling, Bradley, Breitling, Brun, Brunda Nijagal, Creek, Creek, Creek, Darren J. Creek, de Koning, Dong-Hyun Kim, Drexler, Duszenko, Duszenko, Federico Rojas, Geary, Haanstra, Hasne, Hirumi, Hirumi, Hirumi, Jacobs, Keith R. Matthews, Kuettel, Kwon, Lanteri, Lanteri, Mashego, Michael P. Barrett, Mäser, Räz, Saunders, Scalbert, Scheltema, Scheltema, Seed, Sienkiewicz, Smith, Sumner, Sykes, t'Kindt, Tautenhahn, Vincent, Wang, Ward, Wilson, Winder, Wishart, Wu, Zaboikin, Zang, Zhang   +58 more
core   +2 more sources

Nerve damage induced skeletal muscle atrophy is associated with increased accumulation of intramuscular glucose and polyol pathway intermediates [PDF]

, 2020
Perturbations in skeletal muscle metabolism have been reported for a variety of neuromuscular diseases. However, the role of metabolism after constriction injury to a nerve and the associated muscle atrophy is unclear.
Afzal, Shoaib, Kempa, Stefan, Langer, Henning Tim, Spuler, Simone   +3 more
core   +2 more sources

TidyMass an object-oriented reproducible analysis framework for LC–MS data

Nature Communications, 2022
Reproducibility, traceability, and transparency have been long-standing issues in metabolomics data analysis. Here, the authors present tidyMass, an R-based computational framework that allows designing traceable, shareable, and reproducible data ...
Xiaotao Shen, Hong Yan, Chuchu Wang, Peng Gao, Caroline H. Johnson, Michael P. Snyder   +5 more
doaj   +1 more source

Open access repository-scale propagated nearest neighbor suspect spectral library for untargeted metabolomics

Nature Communications, 2023
Despite the increasing availability of tandem mass spectrometry (MS/MS) community spectral libraries for untargeted metabolomics over the past decade, the majority of acquired MS/MS spectra remain uninterpreted. To further aid in interpreting unannotated
Wout Bittremieux, Nicole E. Avalon, Sydney P. Thomas, Sarvar A. Kakhkhorov, Alexander A. Aksenov, Paulo Wender P. Gomes, Christine M. Aceves, Andrés Mauricio Caraballo-Rodríguez, Julia M. Gauglitz, William H. Gerwick, Tao Huan, Alan K. Jarmusch, Rima F. Kaddurah-Daouk, Kyo Bin Kang, Hyun Woo Kim, Todor Kondić, Helena Mannochio-Russo, Michael J. Meehan, Alexey V. Melnik, Louis-Felix Nothias, Claire O’Donovan, Morgan Panitchpakdi, Daniel Petras, Robin Schmid, Emma L. Schymanski, Justin J. J. van der Hooft, Kelly C. Weldon, Heejung Yang, Shipei Xing, Jasmine Zemlin, Mingxun Wang, Pieter C. Dorrestein   +31 more
doaj   +1 more source

Cross-Platform Comparison of Untargeted and Targeted Lipidomics Approaches on Aging Mouse Plasma. [PDF]

, 2018
Lipidomics - the global assessment of lipids - can be performed using a variety of mass spectrometry (MS)-based approaches. However, choosing the optimal approach in terms of lipid coverage, robustness and throughput can be a challenging task.
Brunet, Anne, Contrepois, Kévin, Hornburg, Daniel, Mahmoudi, Salah, Papsdorf, Katharina, Snyder, Michael, Ubhi, Baljit K   +6 more
core   +3 more sources