Results 11 to 20 of about 56,044 (294)
Untargeted Metabolomics Strategies—Challenges and Emerging Directions [PDF]
Journal of the American Society for Mass Spectrometry, 2016 Metabolites are building blocks of cellular function. These species are involved in enzyme-catalyzed chemical reactions and are essential for cellular function. Upstream biological disruptions result in a series of metabolomic changes and, as such, the metabolome holds a wealth of information that is thought to be most predictive of phenotype ...
Alexandra C, Schrimpe-Rutledge +3 more
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Nature Communications, 2023 Untargeted metabolomics is an established approach in toxicology for characterising endogenous metabolic responses to xenobiotic exposure. Detecting the xenobiotic and its biotransformation products as part of the metabolomics analysis provides an ...
Tara J. Bowen +8 more
doaj +1 more source
Cell Reports Medicine, 2021 Summary: Untargeted metabolomics is used to refine the development of biomarkers for the diagnosis of cardiovascular disease. Myocardial infarction (MI) has major individual and societal consequences for patients, who remain at high risk of secondary ...
Karla N. Samman +13 more
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Frontiers in Molecular Biosciences, 2023 Background: Early diagnosis of inherited metabolic diseases (IMDs) is important because treatment may lead to reduced mortality and improved prognosis. Due to their diversity, it is a challenge to diagnose IMDs in time, effecting an emerging need for a ...
Anke P. Willems +11 more
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Mass Spectrometry‐Based Untargeted Plant Metabolomics [PDF]
Current Protocols in Plant Biology, 2019 AbstractMetabolomics has grown into one of the major approaches for systems biology studies, in part driven by developments in mass spectrometry (MS), providing high sensitivity and coverage of the metabolome at high throughput. Untargeted metabolomics allows for the investigation of metabolic phenotypes involving several hundreds to thousands of ...
de Souza, L. +3 more
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Intracellular metabolites in marine microorganisms during an experiment evaluating microbial mortality [PDF]
, 2020 © The Author(s), 2020. This article is distributed under the terms of the Creative Commons Attribution License. The definitive version was published in Longnecker, K., & Kujawinski, E. B.
Kujawinski, Elizabeth B. +1 more
core +1 more source
Metabolites, 2021 Selection for more feed efficient dairy cows is key to improving sustainability and profitability of dairy production; however, underlying mechanisms contributing to individual animal feed efficiency are not fully understood.
Malia J. Martin +6 more
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Enhanced Characterization of Drug Metabolism and the Influence of the Intestinal Microbiome: A Pharmacokinetic, Microbiome, and Untargeted Metabolomics Study. [PDF]
, 2020 Determining factors that contribute to interindividual and intra-individual variability in pharmacokinetics (PKs) and drug metabolism is essential for the optimal use of drugs in humans.
Alhaja, Maher +8 more
core +1 more source
mzMatch-ISO: an R tool for the annotation and relative quantification of isotope-labelled mass spectrometry data [PDF]
, 2013 <p>Motivation: Stable isotope-labelling experiments have recently gained increasing popularity in metabolomics studies, providing unique insights into the dynamics of metabolic fluxes, beyond the steady-state information gathered by routine mass ...
Achuthanunni Chokkathukalam +21 more
core +6 more sources
Seminal plasma metabolomics signatures of normosmic congenital hypogonadotropic hypogonadism
Heliyon, 2023 Background: Normosmic congenital hypogonadotropic hypogonadism (nCHH) is a rare disease, whose pathogenesis remains unclear. Here, we conducted untargeted metabolomics and lipidomics to identify seminal plasma signatures of nCHH, and to study the effect ...
Xiaogang Li +9 more
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