Results 11 to 20 of about 124,046 (257)

Challenges in ESI-MS-based Untargeted Metabolomics [PDF]

CHIMIA, 2022
Untargeted metabolomics is now widely recognized as a useful tool for exploring metabolic changes taking place in biological systems under different conditions.
Serge Rudaz, Elena Tobolkina, Víctor González-Ruiz, Isabel Meister, Miguel De Figueiredo, Davy Guillarme, Julien Boccard   +6 more
doaj   +2 more sources

Untargeted Metabolomics in Fermented Food Systems

Fermentation
Fermented foods are chemically complex systems in which substrate composition, microbial community dynamics, and physicochemical conditions interact to generate thousands of metabolites across diverse chemical classes.
Clarisse M. Lopes, Luis F. Guido
doaj   +2 more sources

Circulating Metabolites Indicate Differences in High and Low Residual Feed Intake Holstein Dairy Cows

Metabolites, 2021
Selection for more feed efficient dairy cows is key to improving sustainability and profitability of dairy production; however, underlying mechanisms contributing to individual animal feed efficiency are not fully understood.
Malia J. Martin, Ryan S. Pralle, Isabelle R. Bernstein, Michael J. VandeHaar, Kent A. Weigel, Zheng Zhou, Heather M. White   +6 more
doaj   +1 more source

Seminal plasma metabolomics signatures of normosmic congenital hypogonadotropic hypogonadism

Heliyon, 2023
Background: Normosmic congenital hypogonadotropic hypogonadism (nCHH) is a rare disease, whose pathogenesis remains unclear. Here, we conducted untargeted metabolomics and lipidomics to identify seminal plasma signatures of nCHH, and to study the effect ...
Xiaogang Li, Ye Guo, Xi Wang, Haolong Li, Jiangfeng Mao, Songxin Yan, Guoju Luo, Renzhi Wang, Xueyan Wu, Yongzhe Li   +9 more
doaj   +1 more source

Benchmarking Outlier Detection Methods for Detecting IEM Patients in Untargeted Metabolomics Data

Metabolites, 2023
Untargeted metabolomics (UM) is increasingly being deployed as a strategy for screening patients that are suspected of having an inborn error of metabolism (IEM).
Michiel Bongaerts, Purva Kulkarni, Alan Zammit, Ramon Bonte, Leo A. J. Kluijtmans, Henk J. Blom, Udo F. H. Engelke, David M. J. Tax, George J. G. Ruijter, Marcel J. T. Reinders   +9 more
doaj   +1 more source

Application of UPLC-QTOF-MS Based Untargeted Metabolomics in Identification of Metabolites Induced in Pathogen-Infected Rice

Plants, 2021
Metabolomics is a useful tool for comparing metabolite changes in plants. Because of its high sensitivity, metabolomics combined with high-resolution mass spectrometry (HR-MS) is the most widely accepted metabolomics tools. In this study, we compared the
Mira Oh, SeonJu Park, Hun Kim, Gyung Ja Choi, Seung Hyun Kim   +4 more
doaj   +1 more source

Untargeted metabolomics based prediction of therapeutic potential for apigenin and chrysin [PDF]

, 2022
Flavonoids belong to the polyphenol superfamily and present in our foods derived from natural sources including fruits and vegetables. Apigenin and Chrysin, prominent flavonoids have been demonstrated to have systemic benefits.
Angela, Leontyev, Cole , Cochran, Katelyn, Martin, Daniel, Rafferty, Jennifer , Choi, Sonali, Kurup, Prasanth, Puthanveetil, Akanksh, Shetty   +7 more
core   +1 more source

mzMatch-ISO: an R tool for the annotation and relative quantification of isotope-labelled mass spectrometry data [PDF]

, 2013
<p>Motivation: Stable isotope-labelling experiments have recently gained increasing popularity in metabolomics studies, providing unique insights into the dynamics of metabolic fluxes, beyond the steady-state information gathered by routine mass ...
Achcar, Fiona,, Chokkathukalam, Achuthanunni, Creek, DJ, Barrett, M.P., Chokkathukalam, A., Breitling, Rainer, Creek, D.J., Breitling, R., Breitling, Rainer,, Achcar, Fiona, Achcar, F., Chokkathukalam, Achuthanunni,, Breitling, R, Jankevics, A, Jankevics, A., Jankevics, Andris, Creek, Darren J.,, Creek, Darren J., Achcar, F, Barrett, MP, Barrett, Michael P., Chokkathukalam, A, Jankevics, Andris,, Barrett, Michael P.,   +23 more
core   +3 more sources

Spatially resolved sampling of the human oral cavity for metabolic profiling

STAR Protocols, 2021
Summary: Here, we present a spatially resolved sampling protocol for the oral human cavity aimed at untargeted metabolomics. We describe the spatial collection of salivary biospecimens, their preparation, and subsequent mass-spectrometry-based untargeted
Alessio Ciurli, Rico J.E. Derks, Maximilian Liebl, Christine Ammon, Jacques Neefjes, Martin Giera   +5 more
doaj   +1 more source

Inter-laboratory reproducibility of fast gas chromatography-electron impact-time of flight mass spectrometry (GC-EI-TOF/MS) based plant metabolomics [PDF]

, 2009
The application of gas chromatography¿mass spectrometry (GC¿MS) to the `global¿ analysis of metabolites in complex samples (i.e. metabolomics) has now become routine.
Dunn, Warwick, Luedemann, A., Lüdemann, A., Arjen Lommen, Goodacre, R., Lommen, Arjen, Lorraine Kay, Dunn, Warwick B., Joachim Kopka, Allwood, J. William, de Koning, S., Erban, Alexander, Kay, Lorraine, Sjaak de Koning, Ralf Löscher, Erban, A., Alexander Erban, Royston Goodacre, de Koning, Sjaak, Löscher, R., Goodacre, Royston, Allwood, J., Kay, L., Allwood, J.W., Dun, W.B., Lommen, A., Kopka, J., Koning, S., Alexander Luedemann, Dunn, W. B., Allwood, J. W., J. William Allwood, Luedemann, Alexander, Dunn, Warwick B, Dunn, W., Kopka, Joachim, Allwood, James, Löscher, Ralf, Warwick B. Dunn   +38 more
core   +1 more source