Results 21 to 30 of about 42,982 (161)

mzMatch-ISO: an R tool for the annotation and relative quantification of isotope-labelled mass spectrometry data [PDF]

, 2013
<p>Motivation: Stable isotope-labelling experiments have recently gained increasing popularity in metabolomics studies, providing unique insights into the dynamics of metabolic fluxes, beyond the steady-state information gathered by routine mass ...
Achcar, Fiona,, Chokkathukalam, Achuthanunni, Creek, DJ, Barrett, M.P., Chokkathukalam, A., Breitling, Rainer, Creek, D.J., Breitling, R., Breitling, Rainer,, Achcar, Fiona, Achcar, F., Chokkathukalam, Achuthanunni,, Breitling, R, Jankevics, A, Jankevics, A., Jankevics, Andris, Creek, Darren J.,, Creek, Darren J., Achcar, F, Barrett, MP, Barrett, Michael P., Chokkathukalam, A, Jankevics, Andris,, Barrett, Michael P.,   +23 more
core   +1 more source

Inter-laboratory reproducibility of fast gas chromatography-electron impact-time of flight mass spectrometry (GC-EI-TOF/MS) based plant metabolomics [PDF]

, 2009
The application of gas chromatography¿mass spectrometry (GC¿MS) to the `global¿ analysis of metabolites in complex samples (i.e. metabolomics) has now become routine.
Dunn, Warwick, Luedemann, A., Lüdemann, A., Arjen Lommen, Goodacre, R., Lommen, Arjen, Lorraine Kay, Dunn, Warwick B., Joachim Kopka, Allwood, J. William, de Koning, S., Erban, Alexander, Kay, Lorraine, Sjaak de Koning, Ralf Löscher, Erban, A., Alexander Erban, Royston Goodacre, de Koning, Sjaak, Löscher, R., Goodacre, Royston, Allwood, J., Kay, L., Allwood, J.W., Dun, W.B., Lommen, A., Kopka, J., Koning, S., Alexander Luedemann, Dunn, W. B., Allwood, J. W., J. William Allwood, Luedemann, Alexander, Dunn, Warwick B, Dunn, W., Kopka, Joachim, Allwood, James, Löscher, Ralf, Warwick B. Dunn   +38 more
core   +1 more source

Intra- and inter-metabolite correlation spectroscopy of tomato metabolomics data obtained by liquid chromatography-mass spectrometry and nuclear magnetic resonance [PDF]

, 2008
Nuclear magnetic resonance (NMR) and liquid chromatography-mass spectrometry (LCMS) are frequently used as technological platforms for metabolomics applications.
de Vos, C.H., Moco, S.I.A., Forshed, J., Vos, C.H., de, Bino, R.J., Vervoort, J.J.M.   +5 more
core   +1 more source

Improved Annotation of Untargeted Metabolomics Data Through Buffer Modifications That Shift Adduct Mass and Intensity [PDF]

, 2020
Annotation of untargeted high-resolution full-scan LC-MS metabolomics data remains challenging due to individual metabolites generating multiple LC-MS peaks arising from isotopes, adducts and fragments. Adduct annotation is a particular challenge, as the
Li, Chen, Lin, Wang, Melanie, McReynolds, Xi, Xing, Joshua D, Rabinowitz, Sisi, Zhang, Wenyun, Lu   +6 more
core   +1 more source

Establishing a framework for best practices for quality assurance and quality control in untargeted metabolomics. [PDF]

, 2023
BackgroundQuality assurance (QA) and quality control (QC) practices are key tenets that facilitate study and data quality across all applications of untargeted metabolomics. These important practices will strengthen this field and accelerate its success.
Kuligowski, Julia, Wilson, Ian D, Ulmer Holland, Candice Z, Vuckovic, Dajana, Theodoridis, Georgios, Lewis, Matthew R, Beecher, Chris W, Dunn, Warwick B, Mosley, Jonathan D, Zanetti, Krista A, Schock, Tracey B   +10 more
core   +1 more source

A Taguchi Design of Experiments Approach for Untargeted Metabolomics Sample Preparation Optimization [PDF]

, 2022
Metabolomics commonly uses analytical techniques such as nuclear magnetic resonance (NMR) and liquid chromatography coupled to mass spectrometry (LC-MS) to quantify and identify metabolites associated with biological variation.
Arthur S., Edison, I. Jonathan, Amster, Brianna M., Garcia, Goncalo J., Gouveia, Ricardo M., Borges, Franklin E., Leach III, Amanda O., Shaver   +6 more
core   +1 more source

GARANTIA DE QUALIDADE EM METABOLÔMICA NÃO-ALVO [PDF]

Química Nova
Over the last two decades, metabolomics has emerged as a pivotal tool in multidisciplinary research, providing invaluable insights into metabolome modulations and finding applications across various scientific domains, including medicine and agronomy ...
Andrew M. Teixeira, Julia Maia Galvão de Queiroz, Bruno C. Garrido, Antônio Jorge R. Silva, Anelize Bauermeister, Ricardo M. Borges   +5 more
doaj   +1 more source

Mechanistic Insights into the Metabolic Pathways Using High-Resolution Mass Spectrometry and Predictive Models in Pancreatic β-Cell Lines (β-TC-6)

Biology and Life Sciences Forum, 2023
Objectives: We have previously shown that inhibition of the mTORC1 nutrient-sensing complex by rapamycin and mTORC1/mTORC2 inhibition by either Torin-2 or RapaLink-1 have differential effects on the global untargeted metabolomics in in vivo and in vitro ...
Ghada A. Soliman, Ye He, Rinat Abzalimov
doaj   +1 more source

Untargeted Metabolomics and Steroid Signatures in Urine of Male Pattern Baldness Patients after Finasteride Treatment for a Year [PDF]

, 2020
Male pattern baldness (MPB) has been associated with dihydrotestosterone (DHT) expression. Finasteride treats MPB by inhibiting 5-alpha reductase and blocking DHT production.
Yu Ra Lee, Eunju Im, Jeongae Lee, Han Bin Oh, Jongki Hong, Ki Jung Paeng, Bong Chul Chung, Bark Lynn Lew, Haksoon Kim, Woo-Young Sim   +9 more
core   +1 more source

Towards quality assurance and quality control in untargeted metabolomics studies [PDF]

, 2018
We describe here the agreed upon first development steps and priority objectives of a community engagement effort to address current challenges in quality assurance (QA) and quality control (QC) in untargeted metabolomic studies.
Jones, Christina, Broadhurst, David, Souza, Amanda, Spalholz, Barbara, Shaughnessy, Daniel, Clish, Clary B., Tayyari, Fariba, Spaeder, Timothy, Mosley, Jonathan, Wilson, Ian, Walk, Tilman, Bandukwala, Abbas, Hsu, Ping-Ching, Maruvada, Padma, Bearden, Daniel W, Zanetti, Krista A, Fischer, Steve, Beger, Richard D, Dunn, Warwick B., Lippa, Katrice, Ntai, Ioanna, Kruppa, Gary, Playdon, Mary, Witkin, Keren, Higashi, Richard, Beger, Richard D., Karuso, Helen, Herrington, David, Kachman, Maureen, O'Donovan, Claire, Verma, Mukesh, Derr, Leslie, O’donovan, Claire, Dasari, Surendra, Evans, Annie, Bearden, Daniel W., Hartung, Thomas, Bethan, Bianca, Raftery, Daniel, Dunn, Warwick B, Zanetti, Krista A., Clish, Clary B, Ubhi, Baljit, Flynn, Thomas   +43 more
core   +1 more source