Results 41 to 50 of about 56,044 (294)
Untargeted Metabolomic Analysis Hits the Target [PDF]
Clinical Chemistry, 2007 Propionic (PA) and methylmalonic (MMA) acidemias are inborn errors of the metabolism of several important amino acids, the side chain of the cholesterol molecule, and dietary odd chain-length fatty acids. PA results from a deficiency of mitochondrial propionyl-CoA carboxylase, an enzyme that requires biotin as a cofactor and converts propionyl-CoA to D-
openaire +2 more sources
Generation and quality control of lipidomics data for the alzheimers disease neuroimaging initiative cohort. [PDF]
, 2018 Alzheimers disease (AD) is a major public health priority with a large socioeconomic burden and complex etiology. The Alzheimer Disease Metabolomics Consortium (ADMC) and the Alzheimer Disease Neuroimaging Initiative (ADNI) aim to gain new biological ...
AA Willette +42 more
core +2 more sources
A Python-Based Pipeline for Preprocessing LC–MS Data for Untargeted Metabolomics Workflows
Metabolites, 2020 Preprocessing data in a reproducible and robust way is one of the current challenges in untargeted metabolomics workflows. Data curation in liquid chromatography–mass spectrometry (LC–MS) involves the removal of biologically non-relevant features ...
Gabriel Riquelme +4 more
doaj +1 more source
MetAssign: probabilistic annotation of metabolites from LC–MS data using a Bayesian clustering approach [PDF]
, 2014 Motivation: The use of liquid chromatography coupled to mass spectrometry (LC–MS) has enabled the high-throughput profiling of the metabolite composition of biological samples.
Breitling, Rainer +5 more
core +2 more sources
Characterization of Cabernet Sauvignon Wines by Untargeted HS-SPME GC-QTOF-MS
Molecules, 2022 Untargeted metabolomics approaches are emerging as powerful tools for the quality evaluation and authenticity of food and beverages and have been applied to wine science.
Alejandra Chávez-Márquez +3 more
doaj +1 more source
Sugar Alcohols Have a Key Role in Pathogenesis of Chronic Liver Disease and Hepatocellular Carcinoma in Whole Blood and Liver Tissues. [PDF]
, 2020 The major risk factors for hepatocellular carcinoma (HCC) are hepatitis C and B viral infections that proceed to Chronic Liver Disease (CLD). Yet, the early diagnosis and treatment of HCC are challenging because the pathogenesis of HCC is not fully ...
El-Said, Hala +5 more
core +2 more sources
METABOLÔMICA: DEFINIÇÕES, ESTADO-DA-ARTE E APLICAÇÕES REPRESENTATIVAS
Química NovaMetabolomics is an emerging and promising omics approach used to understand biological mechanisms. By untargeted and targeted metabolomics analyses, metabolites are determined in biological samples (fluids, cells, tissues, etc.) by comparison of control ...
Gisele A. B. Canuto +7 more
doaj +1 more source
Frontiers in Molecular Biosciences, 2021 Metabolomics has been increasingly applied to biomarker discovery, as untargeted metabolic profiling represents a powerful exploratory tool for identifying causal links between biomarkers and disease phenotypes.
Hannes Doerfler +3 more
doaj +1 more source
Updates in metabolomics tools and resources: 2014-2015 [PDF]
, 2016 Data processing and interpretation represent the most challenging and time-consuming steps in high-throughput metabolomic experiments, regardless of the analytical platforms (MS or NMR spectroscopy based) used for data acquisition.
Misra, Biswapriya B. +1 more
core +1 more source
Plants, 2021 Phenolic compounds constitute an important family of natural bioactive compounds responsible for the medicinal properties attributed to Bryophyllum plants (genus Kalanchoe, Crassulaceae), but their production by these medicinal plants has not been ...
Pascual García-Pérez +6 more
doaj +1 more source