Results 41 to 50 of about 124,046 (257)

Untargeted LC–MS/MS analysis reveals metabolomics feature of osteosarcoma stem cell response to methotrexate

Cancer Cell International, 2020
Background Cancer stem cell (CSC) is identified in osteosarcoma (OS) and considered resistant to chemotherapeutic agents. However, the mechanism of osteosarcoma stem cell (OSC) resistant to chemotherapy remains debatable and vague, and the metabolomics ...
Feng Wang, Zhiyu Zhang, Qin Li, Tao Yu, Chengbin Ma   +4 more
doaj   +1 more source

Bifidobacterium Pseudolongum‐Derived Inosine Mitigates Polystyrene Nanoplastics‐Induced Hepatic Injury by Inhibiting the Polarization of M1 Macrophages

Advanced Science, EarlyView.
Probiotic B.p colonization elevated gut‐derived inosine level in the liver, while elevated inosine activated A2AR and subsequently blocked NPs‐induced polarization of M1 macrophages by repressing the miR155/SOCS1/NF‐κB pathway. This reduced the release of inflammatory cytokines and thereby, mitigated NPs‐induced hepatic injury.
Kaikai Zhang, Yuchuan Chen, Jiayuan Wan, Jianzheng Yang, Lijian Chen, Qingyuan Li, Anding Zhou, Nian Zhou, Jiuyang Ding, Qi Wang, Jian Sun   +10 more
wiley   +1 more source

Single‐Cell Transcriptomic Analysis of Tumor Heterogeneity and the Microenvironment in Pseudomyxoma Peritonei

Advanced Science, EarlyView.
This study presents a single‐cell atlas of pseudomyxoma peritonei spanning primary and paired metastatic lesions. Distinct epithelial substates, stromal remodeling, immune exclusion, lipid metabolic reprogramming, and a candidate angiogenic network were identified in metastatic lesions.
Xi Li, Lei Wang, Lei Ai, Zimeng Li, Zhaochangci Chen, Yuchen Luo, Tianran Zhang, Mengjia Liao, Songhao Wang, Jiajia Cui, Ke Liu, Chengxian Guo, Guodong Liu, Jiye Yin, Wei Wu   +14 more
wiley   +1 more source

Untargeted Metabolomics and Steroid Signatures in Urine of Male Pattern Baldness Patients after Finasteride Treatment for a Year

, 2020
Male pattern baldness (MPB) has been associated with dihydrotestosterone (DHT) expression. Finasteride treats MPB by inhibiting 5-alpha reductase and blocking DHT production.
Yu Ra Lee, Eunju Im, Jeongae Lee, Han Bin Oh, Jongki Hong, Ki Jung Paeng, Bong Chul Chung, Bark Lynn Lew, Haksoon Kim, Woo-Young Sim   +9 more
core   +1 more source

Psychological Stress Associated Bile Acid Reprogramming Promotes Hepatocellular Carcinoma Progression

Advanced Science, EarlyView.
Depression is increasingly recognized as a risk factor for chronic diseases, yet its biological impact on cancer remains unclear. Using data from more than 490 000 participants across three international cohorts, we show that depression significantly increases the risk of liver cancer.
Ruijiang Zeng, Mengmeng Wang, Kang Wang, Zhuo Xing, Yulong Hong, Tongtong Li, Geng Zong, Chong Yang, Dan Zhang, Zhangling Chen, Xin Jin   +10 more
wiley   +1 more source

Towards quality assurance and quality control in untargeted metabolomics studies

, 2018
We describe here the agreed upon first development steps and priority objectives of a community engagement effort to address current challenges in quality assurance (QA) and quality control (QC) in untargeted metabolomic studies.
Jones, Christina, Broadhurst, David, Souza, Amanda, Spalholz, Barbara, Shaughnessy, Daniel, Clish, Clary B., Tayyari, Fariba, Spaeder, Timothy, Mosley, Jonathan, Wilson, Ian, Walk, Tilman, Bandukwala, Abbas, Hsu, Ping-Ching, Maruvada, Padma, Bearden, Daniel W, Zanetti, Krista A, Fischer, Steve, Beger, Richard D, Dunn, Warwick B., Lippa, Katrice, Ntai, Ioanna, Kruppa, Gary, Playdon, Mary, Witkin, Keren, Higashi, Richard, Beger, Richard D., Karuso, Helen, Herrington, David, Kachman, Maureen, O'Donovan, Claire, Verma, Mukesh, Derr, Leslie, O’donovan, Claire, Dasari, Surendra, Evans, Annie, Bearden, Daniel W., Hartung, Thomas, Bethan, Bianca, Raftery, Daniel, Dunn, Warwick B, Zanetti, Krista A., Clish, Clary B, Ubhi, Baljit, Flynn, Thomas   +43 more
core   +1 more source

Multi‐tissue Metabolic GWAS and Drought‐Responsive Multi‐omics Reveal the Genetic Basis of the Quinoa Metabolome

Advanced Science, EarlyView.
A multi‐omics framework combining multitissue genome‐wide association studies, metabolomics, transcriptomics, proteomics, and functional validation uncovers the genetic basis of specialized metabolism in quinoa. The study identifies hundreds of metabolite‐associated loci, prioritizes candidate genes for saponin, betalain, and flavonoid biosynthesis ...
Julia von Steimker, Elodie L. Rey, Clara Stanschewski, Regina Wendenburg, Annabella Klemmer, Markéta Macho, Venkatesh P. Thirumalaikumar, Noha O. Saber, Aleksandra Skirycz, Alisdair R. Fernie, Mark Tester, Saleh Alseekh   +11 more
wiley   +1 more source

An LC-QToF MS based method for untargeted metabolomics of human fecal samples [PDF]

, 2020
Introduction: Consensus in sample preparation for untargeted human fecal metabolomics is lacking. Objectives: To obtain sample preparation with broad metabolite coverage for high-throughput LC–MS.
Landberg, Rikard,, Landberg, Rikard, Fristedt, Rikard,, Fristedt, Rikard, Brunius, Carl,, Cheng, Ken,, Brunius, Carl, Cheng, Ken   +7 more
core   +1 more source

Metabolomics: a review of liquid chromatography mass spectrometry-based methods and clinical applications

Türk Biyokimya Dergisi
Metabolomics is a rapidly growing field that aims to understand the complex metabolic pathways involved in health and disease. Liquid chromatography mass spectrometry (LC-MS) based untargeted metabolomics has emerged as a powerful tool for investigating ...
Doğan Halef Okan
doaj   +1 more source

Cross-Omics: Integrating Genomics with Metabolomics in Clinical Diagnostics

Metabolites, 2020
Next-generation sequencing and next-generation metabolic screening are, independently, increasingly applied in clinical diagnostics of inborn errors of metabolism (IEM).
Marten H. P. M. Kerkhofs, Hanneke A. Haijes, A. Marcel Willemsen, Koen L. I. van Gassen, Maria van der Ham, Johan Gerrits, Monique G. M. de Sain-van der Velden, Hubertus C. M. T. Prinsen, Hanneke W. M. van Deutekom, Peter M. van Hasselt, Nanda M. Verhoeven-Duif, Judith J. M. Jans   +11 more
doaj   +1 more source