Results 41 to 50 of about 42,982 (161)

The evolving landscape of untargeted metabolomics [PDF]

, 2021
Aims: Untargeted Metabolomics is a "hypothesis-generating discovery strategy" that compares groups of samples (e.g., cases vs controls); identifies the metabolome and establishes (early signs of) perturbations.
Castaldo G., Ruoppolo M, Stornaiuolo M, Di Minno A, Gelzo M   +4 more
core   +1 more source

The Combination of Untargeted Metabolomics and Machine Learning Predicts the Biosynthesis of Phenolic Compounds in Bryophyllum Medicinal Plants (Genus Kalanchoe)

Plants, 2021
Phenolic compounds constitute an important family of natural bioactive compounds responsible for the medicinal properties attributed to Bryophyllum plants (genus Kalanchoe, Crassulaceae), but their production by these medicinal plants has not been ...
Pascual García-Pérez, Leilei Zhang, Begoña Miras-Moreno, Eva Lozano-Milo, Mariana Landin, Luigi Lucini, Pedro P. Gallego   +6 more
doaj   +1 more source

Untargeted LC–MS/MS analysis reveals metabolomics feature of osteosarcoma stem cell response to methotrexate

Cancer Cell International, 2020
Background Cancer stem cell (CSC) is identified in osteosarcoma (OS) and considered resistant to chemotherapeutic agents. However, the mechanism of osteosarcoma stem cell (OSC) resistant to chemotherapy remains debatable and vague, and the metabolomics ...
Feng Wang, Zhiyu Zhang, Qin Li, Tao Yu, Chengbin Ma   +4 more
doaj   +1 more source

untargeted metabolomics data [PDF]

Untargeted metabolomics study.
Karolina Kaźmierczak-Siedlecka (18430263)
core   +1 more source

Symposium 2: Modern approaches to nutritional research challenges: Targeted and non-targeted approaches for metabolite profiling in nutritional research. [PDF]

, 2010
The present report discusses targeted and non-targeted approaches to monitor single nutrients and global metabolite profiles in nutritional research. Non- targeted approaches such as metabolomics allow for the global description of metabolites in a ...
Lodge, John K., Lodge, John
core   +1 more source

An LCMS-based untargeted metabolomics protocol for cochlear perilymph : highlighting metabolic effects of hydrogen gas on the inner ear of noise exposed Guinea pigs [PDF]

, 2019
Introduction Noise-induced hearing loss (NIHL) is an increasing problem in society and accounts for a third of all cases of acquired hearing loss. NIHL is caused by formation of reactive oxygen species (ROS) in the cochlea causing oxidative stress ...
Laurell, Göran,, Pettersson, C, Pirttila, K, Pierre, Pernilla Videhult,, Haglof, J, Laurell, G, Arvidsson, Torbjörn,, Pirttilä, Kristian, Pierre, Pernilla Videhult, Laurell, Göran, Hedeland, Mikael,, Arvidsson, T, Engskog, M, Hedeland, M, Haglöf, Jakob, Pettersson, Curt,, Haglöf, Jakob,, Arvidsson, Torbjörn, Engskog, Mikael,, Engskog, Mikael, Pierre, PV, Hedeland, Mikael, Pettersson, Curt, Pirttilä, Kristian,   +23 more
core   +1 more source

Handling Missing Values in Untargeted Metabolomics Data [PDF]

, 2019
Currently, the majority of studies using metabolomics data assume that missing values are due to low concentration and impute the missing values to a single value, e.g. half detection threshold, which was shown very high bias4.
Diana van Heemst (28182), Ko Willems van Dijk (72970), Astrid van Hylckama Vlieg (335532), Saskia le Cessie (63838), Jiao Luo (7329069), Raymond Noordam (6267194), FR Rosendaal (813750), Dennis O. Mook-Kanamori (148319), Renée de Mutsert (561980), Faquih (7329035), Maarten van Smeden (5514137)   +10 more
core   +1 more source

untargeted metabolomics for IFN-γ treated BMECs, neg [PDF]

, 2022
all the metabolites identified by untargeted metabolomics for IFN-γ treated BMECs in negative ion ...
Li, Fengyang
core   +1 more source

Cross-Omics: Integrating Genomics with Metabolomics in Clinical Diagnostics

Metabolites, 2020
Next-generation sequencing and next-generation metabolic screening are, independently, increasingly applied in clinical diagnostics of inborn errors of metabolism (IEM).
Marten H. P. M. Kerkhofs, Hanneke A. Haijes, A. Marcel Willemsen, Koen L. I. van Gassen, Maria van der Ham, Johan Gerrits, Monique G. M. de Sain-van der Velden, Hubertus C. M. T. Prinsen, Hanneke W. M. van Deutekom, Peter M. van Hasselt, Nanda M. Verhoeven-Duif, Judith J. M. Jans   +11 more
doaj   +1 more source

Reproducible Untargeted Metabolomics Data Analysis Workflow for Exhaustive MS/MS Annotation [PDF]

, 2021
Motivation Unknown features in untargeted metabolomics and non-targeted analysis (NTA) are identified using fragment ions from MS/MS spectra to predict the structures of the unknown compounds.
Miao, Yu, Georgia, Dolios, Lauren, Petrick   +2 more
core   +1 more source