Results 1 to 10 of about 75,036 (262)
Endoplasmic Reticulum Involvement in Yeast Cell Death [PDF]
Frontiers in Oncology, 2012 Yeast cells undergo programmed cell death (PCD) with characteristic markers associated with apoptosis in mammalian cells including chromatin breakage, nuclear fragmentation, reactive oxygen species generation, and metacaspase activation.
Nicanor eAustriaco
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“Translating” Tumor Hypoxia: Unfolded Protein Response (UPR)–Dependent and UPR-Independent Pathways [PDF]
Molecular Cancer Research, 2006 Abstract Poor oxygenation (hypoxia) is present in the majority of human tumors and is associated with poor prognosis due to the protection it affords to radiotherapy and chemotherapy. Hypoxia also elicits multiple cellular response pathways that alter gene expression and affect tumor progression, including two recently identified ...
Constantinos, Koumenis +1 more
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A high-throughput drug discovery pipeline to optimize kidney normothermic machine perfusion
Frontiers in Physiology, 2022 Kidney transplantation is the only definitive therapy for end-stage kidney disease. The shortage of organs for transplantation is the main limitation of this life-saving treatment.
Smilla Hofmann +8 more
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Theme Series – UPR in cancer [PDF]
Seminars in Cancer Biology, 2015 Over the past decade endoplasmic reticulum (ER) stress signaling pathways have collectively emerged as an essential mechanism at the crossroads of the cellular functions involved in key steps of cancer development. ER stress signaling has pleiotropic roles in cancer, and is involved at the level of cell transformation, tumor growth and metastasis as ...
Hetz, Claudio, Chevet, Eric
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The UPR in atherosclerosis [PDF]
Seminars in Immunopathology, 2013 Multiple systemic factors and local stressors in the arterial wall can disturb the functions of endoplasmic reticulum (ER), causing ER stress in endothelial cells (ECs), smooth muscle cells (SMCs), and macrophages during the initiation and progression of atherosclerosis. As a protective response to restore ER homeostasis, the unfolded protein response (
Alex X, Zhou, Ira, Tabas
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Biology of the Cell, 2023 AbstractProtein folding and protein maturation largely occur in the controlled environment of the Endoplasmic Reticulum (ER). Perturbation to the correct functioning of this organelle leads to altered proteostasis and accumulation of misfolded proteins in the ER lumen.
Ilaria Pontisso +3 more
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médecine/sciences, 2007 The endoplasmic reticulum (ER) is the first compartment in the secretory pathway. In the ER, proteins fold into their native configuration and are modified by post-translational modifications. Perturbations that alter ER homeostasis therefore disrupt folding and lead to the accumulation of unfolded proteins. These perturbations include modifications of
Fabienne Foufelle, Pascal Ferré
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Metabolism and the UPR mt [PDF]
Molecular Cell, 2016 During mitochondrial dysfunction or the accumulation of unfolded proteins within mitochondria, cells employ a transcriptional response known as the mitochondrial unfolded protein response (UPR(mt)) to promote cell survival along with the repair and recovery of defective mitochondria.
Lin, Yi-Fan, Haynes, Cole M.
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Crosstalk between RNA Metabolism and Cellular Stress Responses during Zika Virus Replication
Pathogens, 2020 Zika virus (ZIKV) is a mosquito-borne virus associated with neurological disorders such as Guillain-Barré syndrome and microcephaly. In humans, ZIKV is able to replicate in cell types from different tissues including placental cells, neurons, and ...
Aarón Oyarzún-Arrau +4 more
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Crosstalk Between ER Stress, Unfolded Protein Response (UPR) and Wnt Signaling Pathway in Cancer [PDF]
Iranian Journal of Colorectal Research, 2020 : 1. Context Endoplasmic reticulum stress (ER stess) is associated with endoplasmic reticulum perturbation homeostasis. Prolonged ER stress conditions may induce cell death. Unfolded protein response (UPR) attempts to restore normal cell conditions.
Morvarid Siri +3 more
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