Results 171 to 180 of about 75,036 (262)

Abstract 1866: Loss of CLN1/PPT1 dysregulates anterograde protein-trafficking causing ER-stress and UPR in CLN1 disease

open access: gold, 2023
Nisha Plavelil   +4 more
openalex   +1 more source

Napping during cognitive behavioural therapy for insomnia: Friends or foes?

open access: yesJournal of Sleep Research, Volume 34, Issue 2, April 2025.
Summary Cognitive and Behavioural Therapy for Insomnia (CBT‐I) is the gold standard treatment for chronic insomnia, with one crucial step being the restriction of time spent in bed. This restriction often intensifies early afternoon sleepiness, leading to a natural gateway for a short recuperative nap, which might foster adherence to CBT‐I over time ...
Brice Faraut   +5 more
wiley   +1 more source

IRE1 signaling increases PERK expression during chronic ER stress

open access: yesCell Death and Disease
The Unfolded Protein Response (UPR) is an essential cellular process activated by the accumulation of unfolded proteins within the Endoplasmic Reticulum (ER), a condition referred to as ER stress.
Gideon Ong   +5 more
doaj   +1 more source

Beyond species means – the intraspecific contribution to global wood density variation

open access: yesNew Phytologist, EarlyView.
Summary Wood density is central for estimating vegetation carbon storage and a plant functional trait of great ecological and evolutionary importance. However, the global extent of wood density variation is unclear, especially at the intraspecific level. We assembled the most comprehensive wood density collection to date, including 109 626 records from
Fabian Jörg Fischer   +105 more
wiley   +1 more source

Sensitization of the UPR by loss of PPP1R15A promotes fibrosis and senescence in IPF [PDF]

open access: gold, 2021
Susan J. Monkley   +16 more
openalex   +1 more source

Glucuronoyl Esterase of Pathogenic Phanerochaete carnosa Induces Immune Responses in Aspen Independently of Its Enzymatic Activity

open access: yesPlant Biotechnology Journal, EarlyView.
ABSTRACT Microbial enzymes expressed in plants add new functionalities but occasionally trigger undesirable immune responses. Phanerochaete carnosa glucuronoyl esterase (PcGCE) hydrolyses the bond between lignin and 4‐O‐methyl‐α‐D‐glucuronic acid substituent of glucuronoxylan.
Evgeniy N. Donev   +15 more
wiley   +1 more source

Unpicking the UPR

open access: yesInvestigative Opthalmology & Visual Science, 2012
openaire   +2 more sources

Protoplast‐Based Functional Genomics and Genome Editing: Progress, Challenges and Applications

open access: yesPlant, Cell &Environment, EarlyView.
ABSTRACT Protoplast‐based systems provide a powerful and versatile platform for exploring how plants sense and respond to their environment. By enabling the direct delivery of proteins, DNA, and RNA into plant cells after cell wall removal, this approach facilitates precise molecular dissection of signaling, stress adaptation, and gene regulation ...
Jo‐Wei Allison Hsieh   +8 more
wiley   +1 more source

One day of environment‐induced heat stress causes injury to the murine kidney

open access: yesExperimental Physiology, EarlyView.
Abstract Environment‐induced heat stress (EIHS) results from sustained body temperature elevation owing to prolonged exposure to heat and humidity. We hypothesized that EIHS would cause kidney injury and cellular dysfunction. To test this hypothesis, female C57 mice were exposed to EIHS (n = 14; 37.6°C, 42.0% relative humidity) or thermoneutral (TN ...
Melissa Roths   +3 more
wiley   +1 more source

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