Results 221 to 230 of about 111,661 (295)

Use of Small Organic Molecules to Improve Pancreatic Beta Cell Resilience to IAPP-Induced Proteotoxic Stress. [PDF]

Int J Mol Sci
Valshon K, Kondrot K, Uehara H, Alexander M, Ichii H.   +4 more
europepmc   +1 more source

EIF2α–ATF4–CHAC1 Signalling Links ER Stress to Ferroptosis in Human Aortic Smooth Muscle Cells: Mechanistic Insights and Therapeutic Implications

Journal of Cellular and Molecular Medicine, Volume 30, Issue 9, May 2026.
ABSTRACT Ferroptosis—a regulated, iron‐dependent cell death driven by lipid peroxidation—has been implicated in vascular pathology, yet how endoplasmic reticulum (ER) stress couples to ferroptotic execution in vascular smooth muscle cells (VSMCs) remains unclear.
Changwen Fang, Xiaolong Du, Yadan Wang, Yiqi Jin, Wenbin Wang   +4 more
wiley   +1 more source

Quantitative Proteomics and CRISPR/Cas9 Editing Reveal UPR-Mediated Control of Immunoglobulin Homeostasis in Hybridomas. [PDF]

Adv Sci (Weinh)
Zou R, Lu X, Liu Y, Yang P, Sun S, Liu Y, Mo Y, Zhu G, Lee JS, Guo Y.   +9 more
europepmc   +1 more source

Regulation of Endoplasmic Reticulum Stress by Empagliflozin in Doxorubicin‐Induced Cardiotoxicity in Rats

Journal of Cellular and Molecular Medicine, Volume 30, Issue 9, May 2026.
ABSTRACT Although Doxorubicin (Dox) is an effective anticancer drug, it can cause severe cardiotoxicity. While several mechanisms have been proposed to explain Dox‐induced cardiomyopathy (DIC), strategies to prevent it remain limited. In previous research on isolated cardiomyocytes, we identified that Empagliflozin (EMPA), an antidiabetic drug ...
Akshi Malik, David C. Y. Cheung, D. Allison Ledingham, Danielle Desautels, Joerg Herrmann, Pawan K. Singal, Davinder S. Jassal   +6 more
wiley   +1 more source

Molecular Characterization of Endoplasmic Reticulum (ER) Stress-Associated <i>BiP</i>, <i>IRE1</i>, and <i>XBP1</i> Genes in <i>Diaphorina citri</i> and Their Roles During <i>Candidatus</i> Liberibacter asiaticus Infection. [PDF]

Insects
Xuan Z, Yang X, Peng T, Yuan Y, Liu C, Wang Y, Huang A, Yi L, Wang X, Cao M, Zhou C.   +10 more
europepmc   +1 more source

The Basic Helix–Loop–Helix Transcription Factors UvBhlh1 and UvBhlh6 Coordinate Virulence in the Rice False Smut Fungus Ustilaginoidea virens

Molecular Plant Pathology, Volume 27, Issue 5, May 2026.
Transcription factors UvBhlh1 and UvBhlh6 are essential for early infection and virulence in Ustilaginoidea virens. These two proteins form a heterodimer that cooperatively regulates downstream target genes during pathogenesis. ABSTRACT Ustilaginoidea virens is the causal agent of rice false smut, a devastating and globally widespread fungal disease ...
Huijuan Cao, Hao Gong, Xiaohong Huang, Jialin Lei, Mina Yu, Xiayan Pan, Tianqiao Song, Junjie Yu, Zhongqiang Qi, Yan Du, Rongsheng Zhang, Yongfeng Liu   +11 more
wiley   +1 more source

Manipulation of the Unfolded Protein Response by Intracellular Bacterial Pathogens: Mechanisms of ER Hijacking and Therapeutic Implications. [PDF]

FASEB J
Dai E, Sun D, Zhao Y, Zhang M, Wu Y, Ding J.   +5 more
europepmc   +1 more source

ChREBP‐β Exacerbates Renal Tubular Disorders Caused by Fructose via ATF4

The FASEB Journal, Volume 40, Issue 8, 30 April 2026.
Schematic diagram of the mechanism underlying fructose‐induced renal tubular injury via ChREBP‐β‐mediated disruption of endoplasmic reticulum and mitochondrial homeostasis. This diagram illustrates that fructose induces the transcriptional activation of ChREBP‐β, which subsequently triggers endoplasmic reticulum stress, disturbs inter‐organelle calcium
Ting Fang, Xinyu Yang, Xiaoqing Deng, Jingyi Wang, Ting Li, Hang Guo, Bei Sun, Liming Chen   +7 more
wiley   +1 more source

Functional Characterization of <i>Solanum tuberosum</i> ER Lumen Binding Protein (<i>StBiP</i>) Genes Through Complementation in Yeast <i>kar2</i> Deletion Mutants. [PDF]

Int J Mol Sci
Adhikari B, Gordon DM, Verchot J.
europepmc   +1 more source

The Role of Crosstalk Between the Unfolded Protein Response and Autophagy in Diseases Associated with Sympathetic Nervous System Imbalance: Mechanisms and Therapeutic Perspectives. [PDF]

Int J Mol Sci
Xu B, Yang Y, Wang R.
europepmc   +1 more source