Results 221 to 230 of about 75,497 (305)

WSB.APP/PS1 mice develop age‐dependent cerebral amyloid angiopathy, cerebrovascular dysfunction, and white matter deficits

Alzheimer's &Dementia, Volume 22, Issue 6, June 2026.
Abstract INTRODUCTION Cerebrovascular deficits, including cerebral amyloid angiopathy (CAA), play a key role in Alzheimer's disease (AD) pathogenesis. Here, we characterize the susceptibility of the WSB/EiJ genetic context to human AD‐relevant cerebrovascular phenotypes. METHODS CAA and parenchymal plaque analysis and in vivo neurovascular imaging were
Olivia J. Marola, Asli Uyar, Kelly J. Keezer, Juan Antonio K. Chong Chie, Kevin J. Elk, Abigail E. Cullen, Kierra Eldridge, Scott Persohn, Jonathan Nyandu Kanyinda, Jennifer D. Whitesell, Julie A. Harris, Paul Salama, Ashley E. Walker, Gregory W. Carter, Michael Sasner, Paul R. Territo, Gareth R. Howell, Kristen D. Onos   +17 more
wiley   +1 more source

Brucella Omp25 activates the unfolded protein response to promote intracellular proliferation and inflammation. [PDF]

J Biol Chem
Yang JK, Huang S, Hou YP, Yuan HF, Wang Y, Li M, Cao LB, Xia T, Shu HB, Wu X.   +9 more
europepmc   +1 more source

Navigating Unconditional Positive Regard: Counsellors' Perspectives on Client Disclosures of Child Sexual Abuse Offending

Counselling and Psychotherapy Research, Volume 26, Issue 2, June 2026.
ABSTRACT Objective This study explores counsellors' perceptions of working with clients who disclose thoughts regarding, or experience of perpetrating, sexual abuse of a child. Counselling of such clients is often framed as emotionally draining, distressing and a challenge for the core conditions of a productive therapeutic relationship, specifically ...
Abigail Pustkowski, Sarah J. Manso, Amy E. Burton   +2 more
wiley   +1 more source

Selective Induction of Estrogen Receptor-Dependent Stress Signaling as a Therapeutic Strategy in Resistant Breast Cancer. [PDF]

ACS Med Chem Lett
Renner AC, Kargbo RB.
europepmc   +1 more source

PRAS40 activates the IRE1α-XBP-1-mediated unfolded protein response to exacerbate colorectal cancer by enhancing ST6Gal1-dependent α-2, 6 sialylation of GRP78. [PDF]

Neoplasia
Teng H, Guo Y, Chen X, Fan A, Zhang C, Zhang T, Luo Y, Huang L.   +7 more
europepmc   +1 more source

Imperatorin ameliorates myocardial ischemia‐reperfusion injury by inhibiting endoplasmic reticulum stress‐mediated apoptosis via the PI3K/AKT/Nrf2 pathway

Journal of Cell Communication and Signaling, Volume 20, Issue 2, June 2026.
By activating the PI3K/AKT/Nrf2 pathway, imperatorin can reduce endoplasmic reticulum stress and its mediated apoptosis in cardiomyocytes, improve the pathological changes of myocardial tissue, and thus improve myocardial ischemia/reperfusion injury.
Mingjun Han, Fan Yu, Huanhuan Li
wiley   +1 more source

The Interplay Between Ca²⁺ Homeostasis, Endoplasmic Reticulum Stress, and the Unfolded Protein Response in Human Diseases. [PDF]

Cells
Ranzato E, Martinotti S.
europepmc   +1 more source

Selective Rh(II)‐Catalyzed Intermolecular Oxyamidation and Acid‐Promoted Nucleophilic Cyclization Cascade of Enamides

ChemistryEurope, Volume 4, Issue 6, June 2026.
A structurally diverse series of 1‐amino‐izidine scaffolds was accessed through a cascade process combining rhodium‐catalyzed nitrene‐transfer oxyamidation with subsequent nucleophilic cyclization under acidic conditions, proceeding via an in situ generated iminium intermediate.
Grégory Jestin, Romain Rey‐Rodriguez, Romane Manguin, Pascal Retailleau, Philippe Dauban, Isabelle Gillaizeau   +5 more
wiley   +1 more source

Allergic Inflammation Triggers the Unfolded Protein Response and <i>Ormdl3</i> Expression in Rat Adipocytes, While miR-665 Inhibition Selectively Modulates the IRE1/XBP1 Pathway and IL-6 Secretion. [PDF]

Int J Mol Sci
Nowakowska-Lewicka J, Langwiński W, Wojciechowicz T, Skrzypski M, Narożna B, Kachel M, Sakrajda K, Stachowiak Z, Szczepankiewicz A.   +8 more
europepmc   +1 more source

STING Modulating ER‐Phagy in the Prelimbic Cortex Neurons Contributed to Neuropathic Pain and Emotional Comorbidity

CNS Neuroscience &Therapeutics, Volume 32, Issue 6, June 2026.
SNL induced ER‐phagy impairment and ER stress increase in the PrL neuron via STING and the STING pathway. Our data indicated that enhancing ER‐phagy in PrL neurons might provide analgesic and antidepressant effects through STING and its pathways in SNL mice. ABSTRACT Background Our previous data suggested that autophagy is crucial for neuropathic pain.
Yongda Liu, Xu Yang, Shihui Kuai, Xi Chen, Zhibin Wang, Zhongsheng Yang, Xiaochuan Guo, Xin He, Ping Zhao   +8 more
wiley   +1 more source