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Comparative Analysis of the Expression Patterns of UPR-Target Genes Caused by UPR-Inducing Compounds
Bioscience, Biotechnology, and Biochemistry, 2013Endoplasmic reticulum (ER) stress, due to an accumulation of unfolded proteins in the ER, leads to a process known as the unfolded protein response (UPR). Since the several compounds used to induce UPR have different modes of action, their mechanisms of protein accumulation are thought to be different, but it is unclear whether these compounds can ...
Satoko, Shinjo +3 more
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Science Signaling, 2010
Certain pathogen-sensing receptors activate one arm of the unfolded protein response to maximize transcriptional activation of inflammatory genes.
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Certain pathogen-sensing receptors activate one arm of the unfolded protein response to maximize transcriptional activation of inflammatory genes.
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Unfallversicherung mit Beitragsrückgewähr (UPR)
1995Einige Versicherungsgesellschaften bieten seit Jahrzehnten ein sonderbares Produkt: Unseriose Vertreter werben mit dem Slogan „die Versicherung, die nichts kostet“.
Andreas Jung, Günther Jung
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The UPR and synaptic dysfunction in neurodegeneration
Brain Research, 2016Activation of the unfolded protein response (UPR) is emerging as a common theme in neurodegenerative diseases, seen in both human brain tissue and mouse models. Genetic and pharmacological manipulation of the pathway in several mouse models has shown that this is not a passive consequence of the neurodegeneration process. Rather, over-activation of the
Freeman, Oliver J. +1 more
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2016
Cancer cells are characterized by mutations in both the nuclear and mitochondrial genomes as well as by an oxidative environment. Both of these events can lead to misfolding of proteins and result in proteotoxic stress. While accumulation of misfolded proteins in the cytoplasm can be directly limited by the activity of the 26S proteasome, the presence ...
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Cancer cells are characterized by mutations in both the nuclear and mitochondrial genomes as well as by an oxidative environment. Both of these events can lead to misfolding of proteins and result in proteotoxic stress. While accumulation of misfolded proteins in the cytoplasm can be directly limited by the activity of the 26S proteasome, the presence ...
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Modeling UPR adaptive responses
Nature Chemical Biology, 2014Danilo B Medinas, Claudio Hetz
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