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The biological meaning of the UPR [PDF]
Nature Reviews Molecular Cell Biology, 2013 Artículo de publicación ...
Claudio Hetz
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Nature Reviews Molecular Cell Biology, 2018
Rebecca Taylor discusses the elegance and importance of early discoveries from the Walter laboratory on the unfolded protein response, and why they have become landmark studies.
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Rebecca Taylor discusses the elegance and importance of early discoveries from the Walter laboratory on the unfolded protein response, and why they have become landmark studies.
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Seminars in Immunopathology, 2013
The respiratory tract has a surface area of approximately 70 m(2) that is in direct contact with the external environment. Approximately 12,000 l of air are inhaled daily, exposing the airway epithelium to up to 25 million particles an hour. Several inhaled environmental triggers, like cigarette smoke, diesel exhaust, or allergens, are known inducers ...
Fabiola Osorio +2 more
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The respiratory tract has a surface area of approximately 70 m(2) that is in direct contact with the external environment. Approximately 12,000 l of air are inhaled daily, exposing the airway epithelium to up to 25 million particles an hour. Several inhaled environmental triggers, like cigarette smoke, diesel exhaust, or allergens, are known inducers ...
Fabiola Osorio +2 more
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Brain Research, 2016
The aging process is characterized by tissue decline and the onset of age-associated disease. It is not, however, immutable, and aging can be modulated by various genetic and environmental means. One of the interventions that can modulate lifespan is the activation of cellular stress responses, including the unfolded protein response in the endoplasmic
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The aging process is characterized by tissue decline and the onset of age-associated disease. It is not, however, immutable, and aging can be modulated by various genetic and environmental means. One of the interventions that can modulate lifespan is the activation of cellular stress responses, including the unfolded protein response in the endoplasmic
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Mitochondrial UPR: A Double-Edged Sword
Trends in Cell Biology, 2016The mitochondrial unfolded protein response (UPR(mt)) promotes the recovery of dysfunctional mitochondria. Surprisingly, UPR(mt) activation inadvertently maintains and propagates the deleterious mtDNA in a heteroplasmic Caenorhabditis elegans strain, with detrimental consequences.
Ye, Tian +2 more
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Comparative Analysis of the Expression Patterns of UPR-Target Genes Caused by UPR-Inducing Compounds
Bioscience, Biotechnology, and Biochemistry, 2013Endoplasmic reticulum (ER) stress, due to an accumulation of unfolded proteins in the ER, leads to a process known as the unfolded protein response (UPR). Since the several compounds used to induce UPR have different modes of action, their mechanisms of protein accumulation are thought to be different, but it is unclear whether these compounds can ...
Satoko, Shinjo +3 more
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Science Signaling, 2010
Certain pathogen-sensing receptors activate one arm of the unfolded protein response to maximize transcriptional activation of inflammatory genes.
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Certain pathogen-sensing receptors activate one arm of the unfolded protein response to maximize transcriptional activation of inflammatory genes.
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Unfallversicherung mit Beitragsrückgewähr (UPR)
1995Einige Versicherungsgesellschaften bieten seit Jahrzehnten ein sonderbares Produkt: Unseriose Vertreter werben mit dem Slogan „die Versicherung, die nichts kostet“.
Andreas Jung, Günther Jung
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The UPR and synaptic dysfunction in neurodegeneration
Brain Research, 2016Activation of the unfolded protein response (UPR) is emerging as a common theme in neurodegenerative diseases, seen in both human brain tissue and mouse models. Genetic and pharmacological manipulation of the pathway in several mouse models has shown that this is not a passive consequence of the neurodegeneration process. Rather, over-activation of the
Freeman, Oliver J. +1 more
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2016
Cancer cells are characterized by mutations in both the nuclear and mitochondrial genomes as well as by an oxidative environment. Both of these events can lead to misfolding of proteins and result in proteotoxic stress. While accumulation of misfolded proteins in the cytoplasm can be directly limited by the activity of the 26S proteasome, the presence ...
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Cancer cells are characterized by mutations in both the nuclear and mitochondrial genomes as well as by an oxidative environment. Both of these events can lead to misfolding of proteins and result in proteotoxic stress. While accumulation of misfolded proteins in the cytoplasm can be directly limited by the activity of the 26S proteasome, the presence ...
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