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Science's STKE, 2001
The unfolded protein response (UPR) is a signaling cascade triggered by conditions that cause the accumulation of improperly folded proteins in the endoplasmic reticulum (ER). The ER stress response results in increased expression of genes containing the ER stress response element in their promoters and include the genes for ER chaperones,
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The unfolded protein response (UPR) is a signaling cascade triggered by conditions that cause the accumulation of improperly folded proteins in the endoplasmic reticulum (ER). The ER stress response results in increased expression of genes containing the ER stress response element in their promoters and include the genes for ER chaperones,
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2016
Cancer cells are characterized by mutations in both the nuclear and mitochondrial genomes as well as by an oxidative environment. Both of these events can lead to misfolding of proteins and result in proteotoxic stress. While accumulation of misfolded proteins in the cytoplasm can be directly limited by the activity of the 26S proteasome, the presence ...
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Cancer cells are characterized by mutations in both the nuclear and mitochondrial genomes as well as by an oxidative environment. Both of these events can lead to misfolding of proteins and result in proteotoxic stress. While accumulation of misfolded proteins in the cytoplasm can be directly limited by the activity of the 26S proteasome, the presence ...
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Unfallversicherung mit Beitragsrückgewähr (UPR)
1995Einige Versicherungsgesellschaften bieten seit Jahrzehnten ein sonderbares Produkt: Unseriose Vertreter werben mit dem Slogan „die Versicherung, die nichts kostet“.
Andreas Jung, Günther Jung
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FKBP11 rewires UPR signaling to promote glucose homeostasis in type 2 diabetes and obesity
Cell Metabolism, 2022Mario Andrés Salazar Hernández +1 more
exaly
ERAP1 and the return of the UPR in ankylosing spondylitis
Nature Reviews Rheumatology, 2023Nigil Haroon, Robert D. Inman
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Increasing Stress to Induce Apoptosis in Pancreatic Cancer via the Unfolded Protein Response (UPR)
International Journal of Molecular Sciences, 2023Max Miller +2 more
exaly
Coming Full Circle in the UPR Cycle? Civil Society Stakeholders and Their Role in the UPR
2022Gianni Magazzeni, Eliska Rybar
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The ER Stress/UPR Axis in Chronic Obstructive Pulmonary Disease and Idiopathic Pulmonary Fibrosis
Life, 2021Mahmoud Aghaei +2 more
exaly