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The biological meaning of the UPR [PDF]
Nature Reviews Molecular Cell Biology, 2013 ArtÃculo de publicación ...
Claudio Hetz, Hetz Claudio
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Brain Research, 2016
The aging process is characterized by tissue decline and the onset of age-associated disease. It is not, however, immutable, and aging can be modulated by various genetic and environmental means. One of the interventions that can modulate lifespan is the activation of cellular stress responses, including the unfolded protein response in the endoplasmic
Rebecca C Taylor
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The aging process is characterized by tissue decline and the onset of age-associated disease. It is not, however, immutable, and aging can be modulated by various genetic and environmental means. One of the interventions that can modulate lifespan is the activation of cellular stress responses, including the unfolded protein response in the endoplasmic
Rebecca C Taylor
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Mitochondrial UPR through generations
Nature Cell Biology, 2021Neuronal mitochondria perturbation elicits a mitochondrial unfolded protein response (UPRmt) in peripheral tissues cell non-autonomously, dependent on the Wnt signalling pathway. A study now reveals that a Wnt-mediated increase in maternally inherited mitochondria DNA is responsible for transgenerational UPRmt induced by neuronal mitochondria ...
Mooncheol Park, Meng C. Wang
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Seminars in Immunopathology, 2013
The respiratory tract has a surface area of approximately 70 m(2) that is in direct contact with the external environment. Approximately 12,000 l of air are inhaled daily, exposing the airway epithelium to up to 25 million particles an hour. Several inhaled environmental triggers, like cigarette smoke, diesel exhaust, or allergens, are known inducers ...
Fabiola Osorio +2 more
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The respiratory tract has a surface area of approximately 70 m(2) that is in direct contact with the external environment. Approximately 12,000 l of air are inhaled daily, exposing the airway epithelium to up to 25 million particles an hour. Several inhaled environmental triggers, like cigarette smoke, diesel exhaust, or allergens, are known inducers ...
Fabiola Osorio +2 more
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The UPR and synaptic dysfunction in neurodegeneration
Brain Research, 2016Activation of the unfolded protein response (UPR) is emerging as a common theme in neurodegenerative diseases, seen in both human brain tissue and mouse models. Genetic and pharmacological manipulation of the pathway in several mouse models has shown that this is not a passive consequence of the neurodegeneration process. Rather, over-activation of the
Freeman, Oliver J. +1 more
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Nature Reviews Molecular Cell Biology, 2018
Rebecca Taylor discusses the elegance and importance of early discoveries from the Walter laboratory on the unfolded protein response, and why they have become landmark studies.
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Rebecca Taylor discusses the elegance and importance of early discoveries from the Walter laboratory on the unfolded protein response, and why they have become landmark studies.
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Science Signaling, 2010
Certain pathogen-sensing receptors activate one arm of the unfolded protein response to maximize transcriptional activation of inflammatory genes.
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Certain pathogen-sensing receptors activate one arm of the unfolded protein response to maximize transcriptional activation of inflammatory genes.
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Mitochondrial UPR: A Double-Edged Sword
Trends in Cell Biology, 2016The mitochondrial unfolded protein response (UPR(mt)) promotes the recovery of dysfunctional mitochondria. Surprisingly, UPR(mt) activation inadvertently maintains and propagates the deleterious mtDNA in a heteroplasmic Caenorhabditis elegans strain, with detrimental consequences.
Ye, Tian +2 more
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Measuring the Impact of Cigarette Smoke on the UPR
2011The unfolded protein response (UPR) is a set of pathways activated by the accumulation of improperly folded proteins. It can be triggered by a broad range of stressful conditions which disrupt successful maturation of proteins in the endoplasmic reticulum (ER) by interfering with proper folding, assembly, and posttranslational modification.
Hong, Zhao +3 more
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Use of Chemical Genomics in Assessment of the UPR
2011Glucose deprivation, one of the major physiological conditions in solid tumor, leads to activation of the unfolded protein response (UPR) in cancer cells. The UPR occurs through the transcriptional and translational regulatory mechanisms that improve the capacity of the endoplasmic reticulum (ER) to fold and traffic proteins and allows the cell to ...
Sakae, Saito, Akihiro, Tomida
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