Results 241 to 250 of about 75,497 (305)

Metabolite import by SLC33A1 is required for ATF6 activation during endoplasmic reticulum stress. [PDF]

Life Sci Alliance
George G, Harding HP, Kay R, Ron D, Ordoñez A.   +4 more
europepmc   +1 more source

Emerging perspectives in proteostasis: bridging mechanisms and therapeutics for human diseases. [PDF]

Signal Transduct Target Ther
Borlepawar A, Neu M, Ma Z, Deshpande A, Bühringer H, Hajieva P, Frey N, Rangrez AY.   +7 more
europepmc   +1 more source

Vacuolization as a Novel Approach to Cancer Therapy

Journal of Biochemical and Molecular Toxicology, Volume 40, Issue 6, June 2026.
This review discusses the novel strategy of inducing vacuole formation in cancer cells using small molecules, that induce nonapoptotic cell death mechanisms, such as paraptosis, oncosis, autophagy, and methuosis, and its potential in overcoming resistance to apoptosis‐based cancer therapies.
Mariah Pasternak, Noor Hussein, Veronica Piedra, Saloni Malla, Chandrabose Karthikeyan, Haneen Amawi, Harish Rajak, Charles R. Ashby Jr., R. Jayachandra Babu, Amit K. Tiwari   +9 more
wiley   +1 more source

Activation of unfolded protein response pathways promotes keratinocyte differentiation and ameliorates psoriasis phenotypes. [PDF]

Cell Stress Chaperones
Zhang Z, Tan M, Liu X, Wang W, Chen X, Peng C, Zhao S, Wu L.   +7 more
europepmc   +1 more source

Inhibition of PLA2G15 Alleviates Palmitic Acid‐Induced Lysosomal Membrane Permeabilization in Human Nucleus Pulposus Cells During Intervertebral Disc Degeneration

JOR SPINE, Volume 9, Issue 2, June 2026.
LMP is responsible for lysosomal dysfunction in IDD. The lipid composition changes in the lysosomal membrane, mediated by PLA2G15, are the cause of LMP. The C/EBPα significantly promotes PLA2G15 expression under PA overload stress. Inhibition of PLA2G15 alleviates PA‐induced LMP by inhibiting the hydrolysis of lysosomal membrane phospholipids. ABSTRACT
Liqun Duan, Jiang Jiang, Shuangshuang Tu, Chuanfu Li, Yijun Dong, Yongjin Li, Wenzhi Zhang, Xi Chen   +7 more
wiley   +1 more source

Role of the IRE1α-XBP1 Axis in IgE-Dependent Activation of Mast Cells. [PDF]

Int J Mol Sci
Kouda H, Nagata K, Saito R, Nishiyama C.
europepmc   +1 more source

Oral Microbiome Resilience During SARS‐CoV‐2 Infection and Diversity Shifts After COVID‐19 Vaccination in a Hispanic Population

MicrobiologyOpen, Volume 15, Issue 3, June 2026.
The oral microbiome in Hispanics remains largely resilient during mild SARS‐CoV‐2 infection, showing minimal diversity changes, while COVID‐19 vaccination induces increased microbial evenness and compositional shifts. These findings highlight limited infection impact but suggest vaccination transiently reshapes oral microbial ecology.
Daniela Vargas‐Robles, Jean L. Santos Agrait, Jaleniz Suárez‐Pérez, Frances Vázquez, Anelisse Dominicci‐Maura, Carlos A. Sariol, Carmen Zorrilla, Josefina Romaguera, Filipa Godoy‐Vitorino   +8 more
wiley   +1 more source

Pyra-metho-carnil disrupts cancer cell proteostasis and induces apoptosis by binding to KDEL receptors. [PDF]

Sci Rep
Yoshida K, Nishi K, Kitaguchi T, Matsumoto T, Maruta G, Maeoka H, Ishikura S, Shirasawa S, Tsunoda T.   +8 more
europepmc   +1 more source

Host–Pathogen Dual Targeting With Repurposed Drugs Identifies a Synergistic Therapy for Intracellular Staphylococcus aureus

MicrobiologyOpen, Volume 15, Issue 3, June 2026.
A large intracellular drug‐repurposing screen identifies a potent synergy between 5‐fluoro‐2′‐deoxycytidine and rifapentine, acting through dual host–pathogen targeting to reduce Staphylococcus aureus burdens across strains, cell types, and infection models (created with BioRender).
Blanca Lorente‐Torres, Helena Á. Ferrero, Pablo Castañera, Jesús Llano‐Verdeja, Sergio Fernández‐Martínez, Amanda Herrero‐González, Farzaneh Javadimarand, Roberto López, Jesús F. Aparicio, Andrew M. Edwards, Volker Behrends, Luis M. Mateos, Álvaro Mourenza, Michal Letek   +13 more
wiley   +1 more source

Deciphering the interplay between hypoxia, angiogenesis, and endoplasmic reticulum stress in carcinogenesis: A narrative review. [PDF]

World J Exp Med
Bhardwaj S, Pandey S, Ghosh DK, Sharma T, Jain BP.   +4 more
europepmc   +1 more source