Results 21 to 30 of about 75,036 (262)
Journal of Applied Surfaces and Interfaces, 2020 The thermal degradation of an unsaturated polyester resin and the composite fabricated with porcelain powder obtained from ceramic waste and the resin was studied under non isothermal conditions in argon atmosphere. For kinetic analysis, the TGA/DTG data
Mohamed Farsane +3 more
doaj +1 more source
RNA Biology, 2022 Cells of metazoans respond to internal and external stressors by activating stress response pathways that aim for re-establishing cellular homoeostasis or, if this cannot be achieved, triggering programmed cell death. Problems during translation, arising
Soumasree De, Oliver Mühlemann
doaj +1 more source
Mitochondrial retrograde signaling to the endoplasmic-reticulum regulates unfolded protein responses
Molecular & Cellular Oncology, 2019 Unfolded protein response (UPRs) directs adaption or apoptosis depending on the severity of endoplasmic-reticulum (ER) stress. We found that apoptotic signaling by inositol requiring enzyme 1α (IRE1α), a transducer of UPRs, is suppressed by mitochondrial
Keisuke Takeda, Shigeru Yanagi
doaj +1 more source
Endoplasmic reticulum stress-induced PCD and caspase-like activities involved.
Frontiers in Plant Science, 2014 Plant cells, like cells from other kingdoms, have the ability to self-destruct in a genetically controlled manner. This process is defined as Programmed Cell Death (PCD).
Yao-min eCAI, Jia eYU, Patrick eGALLOIS
doaj +1 more source
Redox controls UPR to control redox [PDF]
Journal of Cell Science, 2014 In many physiological contexts, intracellular reduction–oxidation (redox) conditions and the unfolded protein response (UPR) are important for the control of cell life and death decisions. UPR is triggered by the disruption of endoplasmic reticulum (ER) homeostasis, also known as ER stress. Depending on the duration and severity of the disruption, this
Davide, Eletto +3 more
openaire +2 more sources
Cancer microenvironment and endoplasmic reticulum stress response [PDF]
, 2015 Different stressful conditions such as hypoxia, nutrient deprivation, pH changes, or reduced vascularization, potentially able to act as growth-limiting factors for tumor cells, activate the unfolded protein response (UPR).
Conti, S +5 more
core +4 more sources
TP53 R249S mutation in hepatic organoids captures the predisposing cancer risk
Hepatology, EarlyView., 2022 The systematic approach in elucidating the gain‐of‐function (GOF) roles of TP53 mutations in early liver carcinogenesis. Unique downstream targets of TP53 L3 mutations were identified from chormatin immunoprecipitation sequencing in HCC cell lines, followed by a series of validation assays to substantiate the exclusive transcriptional regulations ...
Yin Kau Lam +10 more
wiley +1 more source
ZIKV infection activates the IRE1-XBP1 and ATF6 pathways of unfolded protein response in neural cells. [PDF]
, 2018 BACKGROUND: Many viruses depend on the extensive membranous network of the endoplasmic reticulum (ER) for their translation, replication, and packaging. Certain membrane modifications of the ER can be a trigger for ER stress, as well as the accumulation ...
Fu, Z +11 more
core +1 more source
Molecular mechanisms involved in endoplasmic reticulum stress development: What do we know today [PDF]
Medicinski PodmladakEndoplasmic reticulum (ER) is an intracellular organelle involved in protein synthesis and folding. When the balance between cell needs for proteins and ER capacity to fold proteins is disrupted, nonfunctional, unfolded, or misfolded proteins accumulate ...
Vidičević-Novaković Sašenka +1 more
doaj +1 more source
The Unfolded Protein Response and its potential role in Huntington's disease [PDF]
, 2012 Huntington's disease (HD) is a progressive, neurodegenerative disease with fatal outcome. Although the disease-causing gene (huntingtin) has been known for some time, the exact cause of neuronal cell death is still unknown.
Kamesh Ayasolla +2 more
core +2 more sources