Endoplasmic reticulum and Golgi stress in microcephaly
Cell Stress, 2019 Microcephaly is a neurodevelopmental condition characterized by a small brain size associated with intellectual deficiency in most cases and is one of the most frequent clinical sign encountered in neurodevelopmental disorders.
Sandrine Passemard +3 more
doaj +1 more source
Dual EGFR inhibition in combination with anti-VEGF treatment: a phase I clinical trial in non-small cell lung cancer. [PDF]
, 2013 BackgroundPreclinical data indicate EGFR signals through both kinase-dependent and independent pathways and that combining a small-molecule EGFR inhibitor, EGFR antibody, and/or anti-angiogenic agent is synergistic in animal models.MethodsWe conducted a ...
Bastida, Christel +11 more
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Pengembangan Perangkat Lunak Generate File Untuk Migrasi Data EPSBED Ke Format Table Feeder PDDIKTI
Jurnal Saintekom, 2017 Based on SK-03, DIKTI requires all universities provide a report on each semester that corresponding to the report format named EPSBED. EPSBED report is one indicator of a study program at the college as it is called active and abiding by the principle ...
Viktor Handrianus Pranatawijaya
doaj +1 more source
Inhibition of IRE1α-mediated XBP1 mRNA cleavage by XBP1 reveals a novel regulatory process during the unfolded protein response [PDF]
, 2017 Background: The mammalian endoplasmic reticulum (ER) continuously adapts to the cellular secretory load by the activation of an unfolded protein response (UPR).
Bulleid, Neil J. +4 more
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Atherosusceptible Shear Stress Activates Endoplasmic Reticulum Stress to Promote Endothelial Inflammation. [PDF]
, 2017 Atherosclerosis impacts arteries where disturbed blood flow renders the endothelium susceptible to inflammation. Cytokine activation of endothelial cells (EC) upregulates VCAM-1 receptors that target monocyte recruitment to atherosusceptible regions ...
Bailey, Keith A +3 more
core +1 more source
Cell‐nonautonomous control of the UPR [PDF]
EMBO reports, 2012 A study published in this issue of EMBO reports shows that the UPR at the intestine is under the control of the nervous system, to facilitate response to stress. This new way of understanding how the UPR is controlled at an organismal level is discussed here.
Martínez, Gabriela +1 more
openaire +3 more sources
Environmental Stressors and the Unfolded Protein Response (UPR) in Exocrine Pancreatic Function
Frontiers in Physiology, 2011 The exocrine pancreas has the greatest synthetic capacity of any mammalian organ and as such is challenged with synthesis, processing and transporting a large load of digestive enzymes.
Stephen J Pandol +5 more
doaj +1 more source
Modulation of the Unfolded Protein Response by the Human Hepatitis B Virus
Frontiers in Microbiology, 2014 During productive viral infection the host cell is confronted with synthesis of a vast amount of viral proteins which must be folded, quality controlled, assembled and secreted, perturbing the normal function of the endoplasmic reticulum (ER).
Norica eBranza-Nichita +2 more
doaj +1 more source
Effectors Targeting the Unfolded Protein Response during Intracellular Bacterial Infection
Microorganisms, 2021 The unfolded protein response (UPR) is a homeostatic response to endoplasmic reticulum (ER) stress within eukaryotic cells. The UPR initiates transcriptional and post-transcriptional programs to resolve ER stress; or, if ER stress is severe or prolonged,
Manal H. Alshareef +2 more
doaj +1 more source
A multi evaporator desalination system operated with thermocline energy for future sustainability [PDF]
, 2018 All existing commercial seawater desalination processes, i.e. thermally-driven and membrane-based reverse osmosis (RO), are operated with universal performance ratios (UPR) varying up to 105, whilst the UPR for an ideal or thermodynamic limit (TL) of ...
Burhan, Muhammad +3 more
core +2 more sources