Unfolded protein response plays a critical role in heart damage after myocardial ischemia/reperfusion in rats. [PDF]
PLoS ONE, 2017 The unfolded protein response (UPR) plays a critical role in cell death mediated by ischemia/reperfusion (I/R) injury. However, little is known about the exact mechanism of UPR signaling pathways after myocardial I/R injury in rats.
Chengcheng Zhang +6 more
doaj +1 more source
An unfolded protein-induced conformational switch activates mammalian IRE1. [PDF]
, 2017 The unfolded protein response (UPR) adjusts the cell's protein folding capacity in the endoplasmic reticulum (ER) according to need. IRE1 is the most conserved UPR sensor in eukaryotic cells.
Acosta-Alvear, Diego +5 more
core +3 more sources
Getting an UPR hand on recovERy [PDF]
Science, 2016 Cell Biology The endoplasmic reticulum (ER) is an intracellular membranous labyrinth that provides the entry point to the secretory pathway. During proteotoxic stress, the ER expands to cope with the added burden of misfolded or unfolded proteins. This is termed the unfolded protein response (UPR).
openaire +2 more sources
A New Family of Ternary Intermetallic Compounds with Dualistic Atomic Ordering – The ZIP Phases
Advanced Materials, EarlyView.The ZIP phases are ternary intermetallic compounds with dualistic atomic ordering, i.e., they exhibit one face‐centered cubic (fcc; space group Fd3¯$\bar 3$m) variant and one hexagonal (space group P63/mmc) variant. The ZIP phases in the Nb‐Si‐Ni system are the Nb3SiNi2 (fcc) and Ni3SiNb2 (hexagonal) ternary IMCs, crystal structure schematics of which ...
Matheus A. Tunes +24 more
wiley +1 more source
The endoplasmic reticulum in plant immunity and cell death [PDF]
, 2012 The endoplasmic reticulum (ER) is a highly dynamic organelle in eukaryotic cells and a major production site of proteins destined for vacuoles, the plasma membrane, or apoplast in plants.
Eichmann, Ruth, Schäfer, P. (Patrick)
core +2 more sources
Advanced Science, EarlyView.PDAC has a poor prognosis due to chemoresistance. We revealed that MCU upregulation is associated with chemoresistance and stemness in PDAC. MCU‐mediated Ca2+ influx induced ER stress, activating the PERK‐ATF4/NRF2 axis to enhance PSAT1/SLC711 expression and glutathione synthesis, reducing ROS and maintaining stemness.
Zekun Li +17 more
wiley +1 more source
The unfolded protein response is not necessary for the G1/S transition, but it is required for chromosome maintenance in Saccharomyces cerevisiae. [PDF]
PLoS ONE, 2010 BACKGROUND: The unfolded protein response (UPR) is a eukaryotic signaling pathway, from the endoplasmic reticulum (ER) to the nucleus. Protein misfolding in the ER triggers the UPR.
Kelsey A Henry +3 more
doaj +1 more source
Malaysia's Human Rights Performance: Assessment of its First Session of Universal Periodic Review in the United Nations Human Rights Council [PDF]
, 2014 Since its inception, the Universal Periodic Review (UPR) has been subjected to a substantial amount of criticism. The mechanism began functioning in 2008, however there have been little made known about the roles and functions of the UPR.
Khoo, Ying Hooi
core +3 more sources
Alkyltriphenylphosphonium Binding to Cardiolipin Triggers Oncosis in Cancer Cells
Advanced Science, EarlyView.Alkyltriphenylphosphonium, exemplified by TPP+‐C14, preferentially accumulates in mitochondria and selectively binds to cardiolipin, a key phospholipid of the inner mitochondrial membrane, causing loss of mitochondrial membrane potential, severe cellular ATP depletion, and calcium imbalance.
Jin Li +8 more
wiley +1 more source
Materials & Design, 2020 Unsaturated polyester resins (UPR) are usually used in the field of electronic appliances, but their inherent flammability and hygroscopicity severely limit their wide application.
Lubin Liu +5 more
doaj +1 more source