Results 61 to 70 of about 75,036 (262)
Periplocin and cardiac glycosides suppress the unfolded protein response
Scientific Reports, 2021 The unfolded protein response (UPR) controls protein homeostasis through transcriptional and translational regulation. However, dysregulated UPR signaling has been associated with the pathogenesis of many human diseases.
Muneshige Tokugawa +13 more
doaj +1 more source
Pancreatic adaptive responses in alcohol abuse: Role of the unfolded protein response. [PDF]
, 2015 The majority of those who drink excessive amounts of alcohol do not develop pancreatic disease. One overarching hypothesis is that alcohol abuse requires additional risk factors, either environmental or genetic, for disease to occur.
Lugea, Aurelia +2 more
core +1 more source
The Journal of Cell Biology, 2007 A stress-coping strategy of the ER is needed in every cell cycle, show Bicknell et al. (page 1017). The ER's unfolded protein response (UPR), previously associated only with unusual or stressful conditions, is needed for the routine event of cytokinesis.
openaire +1 more source
Astrocytic PERK Deficiency Drives Prefrontal Circuit Dysfunction and Depressive‐Like Behaviors
Advanced Science, EarlyView.Chen et al. show that the endoplasmic reticulum (ER) stress sensor PERK is downregulated in prefrontal cortex (PFC) astrocytes in major depressive disorder and in chronic‐stress mouse models. In young mice, astrocyte‐specific PERK loss reduces the synaptogenic cue thrombospondin‐1 (TSP1), leading to synaptic and circuit deficits and depressive‐like ...
Kai Chen +8 more
wiley +1 more source
Understanding the impact of ER stress on lung physiology
Frontiers in Cell and Developmental BiologyHuman lungs consist of a distinctive array of cell types, which are subjected to persistent challenges from chemical, mechanical, biological, immunological, and xenobiotic stress throughout life.
Zhiling Fu, Wei Wang, Yuan Gao
doaj +1 more source
Compound C prevents the unfolded protein response during glucose deprivation through a mechanism independent of AMPK and BMP signaling. [PDF]
PLoS ONE, 2012 Inhibiting the unfolded protein response (UPR) can be a therapeutic approach, especially for targeting the tumor microenvironment. Here, we show that compound C (also known as dorsomorphin), a small-molecule inhibitor of AMP-activated protein kinase ...
Sakae Saito +5 more
doaj +1 more source
Endoplasmic reticulum stress, degeneration of pancreatic islet β-cells, and therapeutic modulation of the unfolded protein response in diabetes. [PDF]
, 2019 BackgroundMyriad challenges to the proper folding and structural maturation of secretory pathway client proteins in the endoplasmic reticulum (ER) - a condition referred to as "ER stress" - activate intracellular signaling pathways termed the unfolded ...
Colon-Negron, Kevin +2 more
core +1 more source
Non-perturbative interactions in string theory [PDF]
, 1992 New non-perturbative interactions in the effective action of two dimensional string theory are described. These interactions are due to ``stringy" instantonsComment: 6 pages, double coulumn Latex, 3 figures not included available as eps files on ...
Brustein, R., Ovrut, B.
core +2 more sources
UPR-Mediated Membrane Biogenesis in B Cells [PDF]
Biochemistry Research International, 2012 The unfolded protein response (UPR) can coordinate the regulation of gene transcription and protein translation to balance the load of client proteins with the protein folding and degradative capacities of the ER. Increasing evidence also implicates the UPR in the regulation of lipid synthesis and membrane biogenesis.
Joseph W. Brewer, Suzanne Jackowski
openaire +3 more sources
Advanced Science, EarlyView.This study investigates the role of M2 macrophage‐derived extracellular vesicles (M2 EVs) in prostate cancer (PCa) metastasis. Mechanistically, M2 EVs horizontally transfer TXNDC5 mRNA to PCa cells, where the molecule induces the mesenchymal‐like state (MLS), enhancing PCa migration and invasion.
Cong Hu +14 more
wiley +1 more source