Results 41 to 50 of about 8,610 (171)

Integrierte chemo‐enzymatische Synthese des mRNA‐Impfstoff‐Bausteins N1‐Methylpseudouridintriphosphat

Angewandte Chemie, Volume 137, Issue 34, August 18, 2025.
Pseudouridin‐5'‐triphosphat (ΨTP) und sein N1‐methyliertes Derivat (m1ΨTP) sind entscheidende Komponenten in der mRNA‐Impfstofftechnologie. Hier wird ein atomökonomischer, ertragreicher biokatalytischer Weg zur Synthese von ΨTP vorgestellt. Zudem wurde ein neuer chemo‐enzymatischer Weg für die m1ΨTP‐Synthese entwickelt.
Martin Pfeiffer, Leo Krammer, Johannes Zöhrer, Rolf Breinbauer, Bernd Nidetzky   +4 more
wiley   +1 more source

Uremic solutes and risk of end stage renal disease in type 2 diabetes [PDF]

, 2014
Here we studied plasma metabolomic profiles as determinants of progression to ESRD in patients with Type 2 diabetes (T2D). This nested case-control study evaluated 40 cases who progressed to ESRD during 8-12 years of follow-up and 40 controls who ...
Berry, Gerard T, Bonventre, Joseph V, Byun, Jaeman, Huang, Xiaoping, Karoly, Edward D, Kensicki, Elizabeth M, Krolewski, Andrzej S, Mathew, Anna V, Meyer, Timothy W, Mohney, Robert P, Niewczas, Monika A, Pennathur, Subramaniam, Sirich, Tammy L, Skupien, Jan, Smiles, Adam, Walker, Walker, Warram, James H   +16 more
core   +1 more source

El Premi Nobel de Química 2015: els mecanismes de reparació del DNA [PDF]

, 2016
La informació genètica es manté durant generacions en un ambient que pot malbaratar la seva integritat. El Premi Nobel de Química 2015 es va concedir als investigadors Tomas Lindahl, Paul Modrich i Aziz Sancar pel seus treballs en el descobriment dels ...
Eritja, Ramon
core  

C-Nucleoside Formation in the Biosynthesis of the Antifungal Malayamycin A. [PDF]

, 2019
Malayamycin A is an unusual bicyclic C-nucleoside, with interesting antiviral, antifungal, and anticancer bioactivity. We report here the discovery and characterization of the biosynthetic pathway to malayamycin by using genome mining of near-identical ...

core   +2 more sources

Stimuli‐Responsive Silica Silanol Conjugates: Strategic Nanoarchitectonics in Targeted Drug Delivery

Small, Volume 20, Issue 39, September 26, 2024.
The silica surface silanol chemistry and its conjugation to different cargos through stimuli‐responsive linkers are highly desired. This review elucidates silica's surface chemistry, types of silanols, silanol number and chemistry, chemical and physical identification, functionalization, and stimuli‐responsive for precise drug delivery systems ...
Shan Mohanan, Xinwei Guan, Mingtao Liang, Ajay Karakoti, Ajayan Vinu   +4 more
wiley   +1 more source

RNA methylation‐related inhibitors: Biological basis and therapeutic potential for cancer therapy

Clinical and Translational Medicine, Volume 14, Issue 4, April 2024.
In this review, several common types of RNA modifications are reviewed, and the role of regulatory factors related to these modifications in cancer progression is discussed. Finally, the latest advances in small molecule inhibitors of these regulatory factors are especially reviewed. Abstract RNA methylation is widespread in nature. Abnormal expression
Huanxiang Chen, Hongyang Liu, Chenxing Zhang, Nan Xiao, Yang Li, Xiangzhuan Zhao, Ruike Zhang, Huihui Gu, Qiaozhen Kang, Junhu Wan   +9 more
wiley   +1 more source

Magic Permutation: QBEmax Achieves High‐Purity C‐to‐T Base Editing By Combining Cas9 Circular Permutation With Deaminase Domain Inlaying

MedComm – Biomaterials and Applications, Volume 4, Issue 4, December 2025.
Min Li, Shaohua Yao
wiley   +1 more source

Abstracts

Molecular Oncology, Volume 19, Issue S1, Page 1-940, June 2025.
Abstracts submitted to the ‘EACR 2025 Congress: Innovative Cancer Science’, from 16–19 June 2025 and accepted by the Congress Organising Committee are published in this Supplement of Molecular Oncology, an affiliated journal of the European Association for Cancer Research (EACR).
wiley   +2 more sources

DNA repair, genome stability and cancer: a historical perspective [PDF]

, 2015
The multistep process of cancer progresses over many years. The prevention of mutations by DNA repair pathways led to an early appreciation of a role for repair in cancer avoidance.
A Karlsson, AC Minella, AL Murphree, AM Taylor, Antony M. Carr, AP Bird, AR Hartman, AR Lehmann, B Karahalil, B Lindell, B Mintz, B Vogelstein, BN Ames, CE Bronner, CH Spruck, CJ Lord, CJ Lord, CM Eischen, D Hanahan, D Pettijohn, DW Felsher, DW Schoppy, E Callen, E Farber, E Farber, EC Friedberg, EC Friedberg, EJ Fox, EJ Fox, EJ Hall, ER Fearon, F Laval, F Zindy, FS Leach, GL Moldovan, GM Cooper, GM Wahl, H Cavanagh, H Lee, HA Waldron, HJ Muller, HJ Muller, I Berenblum, I Martincorena, J Bartkova, J Cairns, J Laval, J Yamtich, JB Gurdon, JD Watson, JE Cleaver, JF Kerr, JM Bishop, K Illmensee, KW Kinzler, LA Loeb, LA Loeb, Laurence H. Pearl, LH Hartwell, LH Pearl, M Serrano, MB Kastan, MD Gray, MD Waterfield, MD Weitzman, ME Moynahan, MS Lindstrom, N Papadopoulos, NC Denko, O Vafa, P Bouwman, P Brookes, P Brookes, P Brookes, P Pott, PC Nowell, PE Polani, Penny A. Jeggo, PL Chen, R Fishel, RA Weinberg, RB Setlow, RE Franklin, RF Hill, RG McKinnell, S Ekholm-Reed, S Ljungquist, S Mai, SJ Baker, SJ Boulton, SK Sharan, SP Lees-Miller, T Boveri, T Lindahl, T Lindahl, TC Yang, TD Halazonetis, TF Deuel, VG Gorgoulis, WJ Burdette, Y Shiloh, Z Cui   +101 more
core   +1 more source

Family-specific scaling laws in bacterial genomes [PDF]

, 2017
Among several quantitative invariants found in evolutionary genomics, one of the most striking is the scaling of the overall abundance of proteins, or protein domains, sharing a specific functional annotation across genomes of given size.
de Lazzari, Eleonora, Grilli, Jacopo, Lagomarsino, Marco Cosentino, Maslov, Sergei   +3 more
core   +3 more sources