DNA glycosylases: in DNA repair and beyond [PDF]
, 2011 The base excision repair machinery protects DNA in cells from the damaging effects of oxidation, alkylation, and deamination; it is specialized to fix single-base damage in the form of small chemical modifications. Base modifications can be mutagenic and/
A Banerjee +167 more
core +2 more sources
Intrinsic Strand-Incision Activity of Human UNG: Implications for Nick Generation in Immunoglobulin Gene Diversification [PDF]
, 2021 Uracil arises in cellular DNA by cytosine (C) deamination and erroneous replicative incorporation of deoxyuridine monophosphate opposite adenine. The former generates C → thymine transition mutations if uracil is not removed by uracil-DNA glycosylase ...
Alexeeva, Marina +9 more
core +1 more source
The glycine-rich motif of Pyrococcus abyssi DNA polymerase D is critical for protein stability. [PDF]
, 2010 En libre-accès sur Archimer : http://archimer.ifremer.fr/doc/00002/11293/7879.pdfInternational audienceA glycine-rich motif described as being involved in human polymerase delta proliferating cell nuclear antigen (PCNA) binding has also been identified ...
Castrec, Benoît +4 more
core +2 more sources
, 2018 Journal of Extracellular Vesicles, Volume 7, Issue S1, April 2018.
Clotilde Théry, Kenneth Witwer
wiley +1 more source
DNA glycosylases: in DNA repair and beyond [PDF]
, 2018 The base excision repair machinery protects DNA in cells from the damaging effects of oxidation, alkylation, and deamination; it is specialized to fix single-base damage in the form of small chemical modifications. Base modifications can be mutagenic and/
Jacobs, Angelika, Schär, Primo
core
Studies on the Biosynthesis of Menaquinone (Vitamin K) and on the Catabolism of Pseudouridine [PDF]
, 2015 The present work describes studies aimed at characterizing enzymes involved in bacterial metabolic pathways using a variety of biochemical methods, analytical techniques and structural studies.
Mahanta, Nilkamal
core
The Evolutionary Diversity of Uracil DNA Glycosylase Superfamily [PDF]
, 2017 Uracil DNA glycosylase (UDG) is a crucial member in the base excision (BER) pathway that is able to specially recognize and cleave the deaminated DNA bases, including uracil (U), hypoxanthine (inosine, I), xanthine (X) and oxanine (O).
Li, Jing
core +1 more source
A rapid reaction analysis of uracil DNA glycosylase indicates an active mechanism of base flipping [PDF]
, 2007 Uracil DNA glycosylase (UNG) is the primary enzyme for the removal of uracil from the genome of many organisms. A key question is how the enzyme is able to scan large quantities of DNA in search of aberrant uracil residues.
Baldwin, Geoff S. +2 more
core +4 more sources
Helix–hairpin–helix protein MJ1434 from Methanocaldococcus jannaschii and EndoIV homologue TTC0482 from Thermus thermophilus HB27 do not process DNA uracil residues [PDF]
, 2010 The mutagenic threat of hydrolytic DNA cytosine deamination is met mostly by uracil DNA glycosylases (UDG) initiating base excision repair. However, several sequenced genomes of archaeal organisms are devoid of genes coding for homologues of the ...
Aravind +48 more
core +2 more sources
The Methanothermobacter thermautotrophicus ExoIII homologue Mth212 is a DNA uridine endonuclease [PDF]
, 2006 The genome of Methanothermobacter thermautotrophicus, as a hitherto unique case, is apparently devoid of genes coding for general uracil DNA glycosylases, the universal mediators of base excision repair following hydrolytic deamination of DNA cytosine ...
Alan I. Majerník +39 more
core +4 more sources