Results 91 to 100 of about 62,313 (168)
Influence of Cosolvents on the Pressure Stability of Human Serum Albumin
physica status solidi (a), EarlyView.Human serum albumin is able to bind various hydrophobic substances and drugs. To investigate this interaction, the protein structure is analyzed using small‐angle X‐ray scattering under high hydrostatic pressure. The resulting radius of gyration (see picture) indicates that hydrophobic substances influence the pressure stability of HSA differently ...
Jaqueline Savelkouls +3 more
wiley +1 more source
Small Science, EarlyView.Two‐dimensional graphene‐based nanomaterials are of significant interest in biomedical applications due to their unique physicochemical properties. Computational modeling provides useful insights into their structure and interactions with biological systems, aiding the nanoparticle design.
Alexa Kamboukos +2 more
wiley +1 more source
Hyperspectral Raman imaging to understand patterns in dried biofluids in Alzheimer's disease
VIEW, EarlyView.Raman spectroscopy is commonly used to identify biomarkers in biological fluids, often focusing on the outer ring of dried droplets due to molecular accumulation from the coffee ring effect. However, this approach may overlook important spectral information, so hyperspectral Raman mapping is used to analyze the entire droplet and identify optimal ...
Eneko Lopez +8 more
wiley +1 more source
Molecular Ecology Resources, EarlyView.ABSTRACT The condition of ancient marine ecosystems provides context for contemporary biodiversity changes in human‐impacted oceans. Sequencing sedimentary ancient DNA (sedaDNA) is an emerging method for generating high‐resolution biodiversity time‐series data, offering insights into past ecosystems.
Luke E. Holman +8 more
wiley +1 more source
Designing Epigenetic Clocks for Wildlife Research
Molecular Ecology Resources, EarlyView.ABSTRACT The applications of epigenetic clocks – statistical models that predict an individual's age based on DNA methylation patterns – are expanding in wildlife conservation and management. This growing interest highlights the need for field‐specific design best practices.
Levi Newediuk +5 more
wiley +1 more source
Independent Avian Epigenetic Clocks for Ageing and Development
Molecular Ecology Resources, EarlyView.ABSTRACT Information on individual age is a fundamental aspect in many ecological and evolutionary studies. However, accurate and non‐lethal methods that can be applied to estimate the age of wild animals are often absent. Furthermore, since the process of ageing is accompanied by a physical decline and the deterioration of biological functions, the ...
Ayke Haller +3 more
wiley +1 more source
ERNEST COST action overview on the (patho)physiology of GPCRs and orphan GPCRs in the nervous system
British Journal of Pharmacology, EarlyView.G protein‐coupled receptors (GPCRs) are a large family of cell surface receptors that play a critical role in nervous system function by transmitting signals between cells and their environment. They are involved in many, if not all, nervous system processes, and their dysfunction has been linked to various neurological disorders representing important
Necla Birgül Iyison +15 more
wiley +1 more source
Cancer Science, EarlyView.With the aim of clinical applications, we established a simplified evaluation method for BRCA1 methylation using fragment analysis, called BRCA1‐FAM. We confirmed that high‐grade serous ovarian cancer patients with BRCA1 methylation had poor prognosis.
Saki Tsuchimochi +20 more
wiley +1 more source
Cancer Science, EarlyView.Our study reveals that hypoxia inhibitors ameliorate iodine uptake dysfunction in thyroid cancer by acting on the hsa_circ_0023990/miR‐448/DNMT1/NIS signaling pathway. ABSTRACT This research seeks to investigate how hypoxia inhibitors enhance iodine uptake in thyroid cancer cells. Clinical samples were gathered and assessed for hsa_circ_0023990, DNMT1,
Ruiqin Gou +5 more
wiley +1 more source
Stress‐inducible phosphoprotein 1 (Sti1/Stip1/Hop) sequesters misfolded proteins during stress
The FEBS Journal, EarlyView.Stress‐inducible phosphoprotein 1 (Sti1/Stip1/Hop) is a major co‐chaperone to both Hsp90 and Hsp70. We find that misbalanced expression of Sti1 in yeast and mammalian cells causes severe growth defects. Deletion of STI1 causes an accumulation of soluble misfolded ubiquitinated proteins and a strong activation of the heat shock response.
Benjamin S. Rutledge +7 more
wiley +1 more source