Time-dependent density functional theory molecular dynamics simulation of doubly charged uracil in gas phase [PDF]
Open Physics, 2014 López-Tarifa Pablo +11 more
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A Prebiotic Ribosylation of Pyrimidine Nucleobases Enabled by Metal Cations and Clay Minerals
Life, 2021 We report a prebiotically relevant solution to the N1-ribosylation of pyrimidine nucleobases, a well-known challenge to the RNA world hypothesis. We found that the presence of metal cations and clay minerals enable the previously unachievable direct ...
Qian-Qian Chen, Ze-Run Zhao, Xiao Wang
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Pharmaceuticals, 2022 A series of quinoline–uracil hybrids (10a–l) has been rationalized and synthesized. The inhibitory activity against hCA isoforms I, II, IX, and XII was explored.
Samar A. El-Kalyoubi +4 more
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Synthesis of Natural Product-Like Tricyclic Higher-Carbon Sugar Nucleosides
Pharmaceutical Fronts, 2021 Because of the structural novelty and interesting biological profiles, the synthesis of higher-carbon sugars has been highly pursued. In this work, we first synthesized a series of structurally novel bis-uracil containing tricyclic higher-carbon sugar ...
Xiao-Han Yuan +4 more
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Electrocatalytic multicomponent assembling of aminouracils, aldehydes and malononitrile: An efficient approach to 7-amino-pyrido[2,3-d]pyrimidine-6-carbonitrile derivatives [PDF]
Journal of the Serbian Chemical Society, 2016 Electrocatalytic multicomponent transformation of 6-aminouracils, aromatic aldehydes and malononitrile in ethanol in an undivided cell in the presence of potassium bromide as an electrolyte leads to 7-amino-pyrido[2,3- d]pyrimidine-6 ...
Kazemi-Rad Reyhaneh +2 more
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Uracil-DNA glycosylases preferentially excise mispaired uracil [PDF]
Biochemical Journal, 1992 We have investigated the substrate specificity of human, viral and bacterial uracil-DNA glycosylases employing as substrate double-stranded oligonucleotides containing in the same position of the 5′-32P-labelled strand an uracil residue facing, on the complementary strand, guanine (mimicking cytosine deamination) or adenine (mimicking dUTP ...
VERRI A +3 more
openaire +3 more sources
Synthesis, Characterization and Antibacterial activities of Uracil and Uracil–Oxalate Complexes with Cr(III) and Fe(III) [PDF]
Engineering and Technology Journal, 2019 New complexes of the some trivalent transition metal ions of the uracil such as [M(Ura)3Cl3] and mixed ligand metal complexes with uracil and oxalic acid [M(Ura)2(OA)(OH2)Cl].H2O type, where (Ura)=Uracil, (OA= Oxalic acid dihydrate, (M= Cr+3 and Fe+3 ...
Shatha Obaid
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Optimisation of the Schizosaccharomyces pombe urg1 expression system [PDF]
, 2013 The ability to study protein function in vivo often relies on systems that regulate the presence and absence of the protein of interest. Two limitations for previously described transcriptional control systems that are used to regulate protein expression
A Yamashita +34 more
core +8 more sources
Uracil-containing DNA in Drosophila: stability, stage-specific accumulation, and developmental involvement. [PDF]
PLoS Genetics, 2012 Base-excision repair and control of nucleotide pools safe-guard against permanent uracil accumulation in DNA relying on two key enzymes: uracil-DNA glycosylase and dUTPase.
Villő Muha +12 more
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Ultrafast Photo-Ion Probing of the Relaxation Dynamics in 2-Thiouracil
Molecules, 2023 In this work, we investigate the relaxation processes of 2-thiouracil after UV photoexcitation to the S2 state through the use of ultrafast, single-colour, pump-probe UV/UV spectroscopy. We place focus on investigating the appearance and subsequent decay
Matthew Scott Robinson +2 more
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