Results 131 to 140 of about 22,593 (200)

HR‐MS Analysis of the Covalent Binding of Edaravone to 5‐Formylpyrimidine Bases and a DNA Oligonucleotide Containing a 5‐Formylcytidine Residue

Rapid Communications in Mass Spectrometry, Volume 39, Issue 14, 30 July 2025.
ABSTRACT Rationale Edaravone (EDA) is a radical scavenger and an antioxidant drug approved to treat amyotrophic lateral sclerosis and used as a research tool to explore treatment of neurodegenerative diseases and cancers. It is also a reactive agent, known as PMP (1‐phenyl‐3‐methyl‐5‐pyrazolone), used for the analysis of polysaccharides composition ...
Romain Regnault, Mostafa Kouach, Laurence Goossens, Xavier Thuru, Christian Bailly, Jean‐François Goossens   +5 more
wiley   +1 more source

Organic Hazes as a Source of Life’s Building Blocks to Warm Little Ponds on the Hadean Earth

The Planetary Science Journal
Over 4 billion years ago, Earth is thought to have been a hazy world akin to Saturn’s moon Titan. The organic hazes in the atmosphere at this time could have contained a vast inventory of life’s building blocks and thus may have seeded warm little ponds ...
Ben K. D. Pearce, Sarah M. Hörst, Joshua A. Sebree, Chao He   +3 more
doaj   +1 more source

Optimisation of Heated Electrospray Ionisation Parameters to Minimise In‐Source Generated Impurities in the Analysis of Oligonucleotide Therapeutics

Rapid Communications in Mass Spectrometry, Volume 39, Issue 13, 15 July 2025.
ABSTRACT Rationale Oligonucleotides have emerged as an important new class of therapeutic. Due to their structural complexity, this presents significant challenges for the development of analytical methods to characterise and determine their impurity profile.
Mollie A. Glenister, Ulrik Mistarz, Ken Cook, James L. Stephenson, Mark J. Dickman   +4 more
wiley   +1 more source

ERNEST COST action overview on the (patho)physiology of GPCRs and orphan GPCRs in the nervous system

British Journal of Pharmacology, Volume 182, Issue 14, Page 3178-3210, July 2025.
G protein‐coupled receptors (GPCRs) are a large family of cell surface receptors that play a critical role in nervous system function by transmitting signals between cells and their environment. They are involved in many, if not all, nervous system processes, and their dysfunction has been linked to various neurological disorders representing important
Necla Birgül Iyison, Clauda Abboud, Dayana Abboud, Abdulrasheed O. Abdulrahman, Ana‐Nicoleta Bondar, Julie Dam, Zafiroula Georgoussi, Jesús Giraldo, Anemari Horvat, Christos Karoussiotis, Alba Paz‐Castro, Miriam Scarpa, Hannes Schihada, Nicole Scholz, Bilge Güvenc Tuna, Nina Vardjan   +15 more
wiley   +1 more source

Comparison of the composition, immunological activity and anti-fatigue effects of different parts in sika deer antler

Frontiers in Pharmacology
BackgroundSika deer (Cervus nippon Temminck, 1838) antler is a highly esteemed tonic renowned for its abundant assortment of polypeptides, polysaccharides, amino acids, and minerals, and is recognized for its multifarious pharmacological properties ...
Siqi Chen, Yidan Li, Yichun Yang, Shibo Zhao, Huali Shi, Chengkai Yang, Min Wu, Aiwu Zhang   +7 more
doaj   +1 more source

Prevalence and Whole Genome Sequence Analysis of Mycoplasma bovis Isolates From Bulk Tank Milk of Dairy Farms in Tennessee, USA

Journal of Veterinary Internal Medicine, Volume 39, Issue 4, July/August 2025.
ABSTRACT Background Mycoplasma bovis mastitis is an important disease of dairy cows that causes substantial economic losses. However, its prevalence in different states in the United States (US), including Tennessee, is not well known. Furthermore, recent studies showed a high prevalence of bovine hemotropic mycoplasmas in US dairy farms.
Aga E. Gelgie, Benti D. Gelalcha, Daniel Christensen, Trevor Freeman, Jonathan E. Beever, Oudessa Kerro Dego   +5 more
wiley   +1 more source

Multiple transitions to high l‐DOPA 4,5‐dioxygenase activity reveal molecular pathways to convergent betalain pigmentation in Caryophyllales

New Phytologist, Volume 247, Issue 1, Page 341-357, July 2025.
Summary Many specialized metabolic pathways have evolved convergently in plants, but distinguishing multiple origins from alternative evolutionary scenarios can be difficult. Here, we explore the evolution of l‐3,4‐dihydroxyphenylalanine (l‐DOPA) 4,5‐dioxygenase (DODA) enzymes to better resolve the convergent evolution of the betalain biosynthetic ...
Nathanael Walker‐Hale, M. Alejandra Guerrero‐Rubio, Samuel F. Brockington   +2 more
wiley   +1 more source

Patterns of DNMT1 Promoter Methylation in Patients with Acute Lymphoblastic Leukemia

International Journal of Hematology-Oncology and Stem Cell Research, 2016
Background: Acute lymphoblastic leukemia (ALL) is a clonal malignant disorder characterized by an uncontrolled proliferation of immature T or B lymphocytes.
Tirdad Rahmani, Mehdi Azad, Bahram Chahardouli, Hajar Nasiri, Mousa Vatanmakanian, Saeid Kaviani   +5 more
doaj  

The Direct and Individual Transcriptional Function of the Human Homodimeric and Heterodimeric Basic Helix–Loop–Helix Transcription Factors E47 and Scleraxis

The FASEB Journal, Volume 39, Issue 12, 30 June 2025.
The isolated yeast model allowed visualization of the function of the heterodimeric SCX and E47 transcription factors (TFs) in the absence of other interacting proteins. The findings support the need for additional transcription factor binding sites (TFBS) and a permissive chromatin landscape for these TFs to exert a positive transcriptional effect ...
Karla Miranda López‐Delucio, Tania Dessire Sandoval‐Gurubel, Carina Becerril, Carlos Campero‐Basaldua, Alicia González, Ana Lilia Torres‐Machorro   +5 more
wiley   +1 more source

Phylogenetic analysis of the promoter element 2 of paramyxo- and filoviruses

Microbiology Spectrum
Paramyxo- and filovirus genomes are equipped with bipartite promoters at their 3' ends to initiate RNA synthesis. The two elements, the primary promoter element 1 (PE1) and the secondary promoter element 2 (PE2), are separated by a spacer region that ...
Shoichi Ashida, Shohei Kojima, Takashi Okura, Fumihiro Kato, Wakako Furuyama, Shuzo Urata, Yusuke Matsumoto   +6 more
doaj   +1 more source