Results 151 to 160 of about 566,114 (212)
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Enzymic determination of uracil nucleotides in tissues.
Analytical Biochemistry, 1970Abstract An enzymic assay for the sequential determination of UDP-glucose, UDP-galactose, UTP, UDP, and 5′-UMP in tissues is described. Two moles of NAD are reduced per mole of uracil nucleotide by use of UDPG dehydrogenase as indicator enzyme. The procedure is highly specific for the measurement of uridine 5′-phosphates.
D. Keppler, J. Rudigier, K. Decker
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Uracil nucleotides: from metabolic intermediates to neuroprotection and neuroinflammation.
Biochemical Pharmacology, 2008Uracil nucleotides (i.e., UTP and UDP) have been known for years as fundamental intermediates in the de novo synthesis of the other pyrimidine nucleotides, which altogether represent key building blocks for nucleic acid synthesis. In addition, their sugar conjugates (i.e., UDP-glucose and UDP-galactose) enter in several biochemical routes, for example ...
D. Lecca, S. Ceruti
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P2 receptors activated by uracil nucleotides--an update.
Current Medicinal Chemistry, 2006Pyrimidine nucleotides, including UTP, UDP and UDP-glucose, are important signaling molecules which activate G protein-coupled membrane receptors (GPCRs) of the P2Y family.
A. Brunschweiger, C. Müller
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Receptors responsive to extracellular uracil nucleotides
Drug Development Research, 1998The cloning of P2Y 4 and P2Y 3 (chicken) / P2Y 6 (rat, human) receptors has been the ultimate proof that receptors for pyrimidine nucleotides exist. However, on the basis of their structure these receptors do not constitute a family of their own but belong to the P2Y family, which thus encompasses selective purinoceptors (P2Y 1 , P2Y 11 ), nucleotide
D. Communi +4 more
semanticscholar +3 more sources
Interaction of the retinal G-protein transducin with uracil nucleotides.
Biochemical and Biophysical Research Communications, 1999Little is known about the interaction of pyrimidine nucleotides with G-proteins. Here we report that under experimental conditions that exclude transphosphorylation reactions, nucleoside 5'-triphosphates inhibited transducin-catalyzed GTP hydrolysis in ...
J. F. Klinker, R. Seifert
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Journal of the Chemical Society, Chemical Communications, 1984
Unprotected uracil nucleotides and nucleosides are converted into 5-formyluracil derivatives using a palladium(II) coupling reaction followed by oxidation of the intermediate styryl derivative.
J. Park +4 more
semanticscholar +3 more sources
Unprotected uracil nucleotides and nucleosides are converted into 5-formyluracil derivatives using a palladium(II) coupling reaction followed by oxidation of the intermediate styryl derivative.
J. Park +4 more
semanticscholar +3 more sources
Effects of galactose on human leukocyte uracil nucleotides
International Journal of Biochemistry, 1975Abstract 1. 1. Uracil nucleotide contents of human leukocytes were determined by enzymatic analysis. The labelling pattern of uracil nucleotides was studied after incubation of the cells in the presence of [ 14 C]uridine followed by separation of the labelled nucleotides by paper chromatography. 2. 2. A depression of UTP, UDP, and UDP-glucose
J. Forster, D. Keppler
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Potential signalling roles for UTP and UDP: sources, regulation and release of uracil nucleotides.
Trends in Pharmacological Sciences, 1997Increasing evidence for receptors for uracil nucleotides has focused interest on specific signalling mechanisms involving UTP and UDP. At least three metabotropic P2 receptors are stimulated by uracil nucleotides with equal or greater potency than by adenine nucleotides, and there might be ionotropic receptors as well.
C. Anderson, F. Parkinson
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Advances in myocardiology, 1983
The turnover of cardiac adenine and uracil nucleotides was studied in the hypertrophying rat heart by means of the kinetics of incorporation of labeled phosphate into the alpha-phosphate groups of nucleotides. Cardiac hypertrophy was induced either by chronic isoproterenol treatment (5 mg X kg-1 body wt. daily, s.c.) or by abdominal aortic constriction.
A. Ray +3 more
semanticscholar +4 more sources
The turnover of cardiac adenine and uracil nucleotides was studied in the hypertrophying rat heart by means of the kinetics of incorporation of labeled phosphate into the alpha-phosphate groups of nucleotides. Cardiac hypertrophy was induced either by chronic isoproterenol treatment (5 mg X kg-1 body wt. daily, s.c.) or by abdominal aortic constriction.
A. Ray +3 more
semanticscholar +4 more sources