Results 91 to 100 of about 2,667 (184)

Identification and functional characterization of uric acid transporter Urat1 (Slc22a12) in rats

Biochimica et Biophysica Acta (BBA) - Biomembranes, 2011
Uric acid transporter URAT1 contributes significantly to reabsorption of uric acid in humans to maintain a constant serum uric acid (SUA) level. Since alteration of SUA level is associated with various diseases, it is important to clarify the mechanism of change in SUA.
Sato, Masanobu, Wakayama, Tomohiko, Mamada, Hideaki, Shirasaka, Yoshiyuki, Nakanishi, Takeo, Tamai, Ikumi   +5 more
openaire   +2 more sources

Transport mechanism and structural pharmacology of human urate transporter URAT1

Cell Research
Abstract Urate is an endogenous product of purine metabolism in the liver. High urate levels in the blood lead to gout, a very common and painful inflammatory arthritis. Excreted urate is reabsorbed in the kidney mainly by URAT1 antiporter, a key target for anti-gout drugs.
Yaxin Dai, Chia-Hsueh Lee
openaire   +2 more sources

Homozygous mutations of GLUT9 cause severe renal hypouricemia

, 2009
Hereditary hypouricemia may result from mutations in the renal tubular uric acid transporter URAT1. Whether mutation of other uric acid transporters produces a similar phenotype is unknown.
Sawyer, Lindsay, Amariglio, Ninette, Campbell, Susan, Shu, Xinhua, Richardson, William, Gray, Nicola K., Rechavi, Gideon, Dinour, Dganit, S. Campbell, L. Sawyer, E. J. Holtzman, J. Weissgarten, A. F. Wright, N. K. Gray, G. Rechavi, M. R. Millar, X. Shu, N. Amariglio, D. Dinour, M. Goldman, B.-A. Sela, L. Ganon, H. Bahat, W. Richardson   +23 more
core   +1 more source

Phyllanthi Fructus ameliorates hyperuricemia and kidney injure via inhibiting uric acid synthesis, modulating urate transporters, and alleviating inflammation

Scientific Reports
Phyllanthi Fructus, known as Yuganzi (YGZ), is a unique medicine and food homologous fruit with both medicinal and nutritional properties. Its historical use in treating hyperuricemia (HUA) and gout is well-documented.
Shaoyu Liang, Dandan Xu, Junhong Wu, Qianqian Jiang, Yongchang Zeng   +4 more
doaj   +1 more source

Cathepsin B-dependent glycolysis contributes to reduced renal uric acid excretion in hyperuricemia

Communications Biology
Decreased renal uric acid excretion is a major contributor to hyperuricemia (HUA), but its underlying mechanism remains unclear. Here, we identify cathepsin B (CTSB) as a key regulator of urate handling in HUA.
Huagang Lin, Linjing Nie, Deping Wu, Dexian Zhang, Rui Peng, Sijie Tao, Zhibin Ye, Sibo Zhu, Maoqing Ye, Jing Xiao   +9 more
doaj   +1 more source

A novel method for screening antihyperuricemic drugs by combining aptamer sensor array, exonuclease III-DNA walker and linear discriminant analysis

Journal of Pharmaceutical Analysis
The lack of a cell-based screening method limits urate-lowering drug development. A novel method combining aptamer sensor array (ASA), exonuclease III (Exo III)- powered 3D DNA walker (DW), and linear discriminant analysis (LDA) was developed for ...
Shiquan Zheng, Jiale Ke, Hanren Chen, Huaze Shao, Fengxin Zheng, Runhui Zhang, Zean Zhao, Jianxin Pang, Lihong Liu   +8 more
doaj   +1 more source

Exploration of association mechanism between hyperuricemia and insulin resistance [PDF]

本研究では腎近位尿細管での尿酸再吸収モデルURAT1/GLUT9共発現MDCK2細胞を用いて、インスリンが尿酸の再吸収に及ぼす影響を検討した結果、インスリンによる解糖系の亢進に依存して尿酸再吸収を促進することが示された。URAT1の尿酸輸送の交換基質であるlactateが解糖系による増大することが考えられることから、URAT1単発現HEK293細胞を用いた検討を行った結果、同様に解糖系の亢進が尿酸の細胞内取り込みに寄与することが示された。To determine the effect of ...
00634180, 76443, 小森, 久和
core   +1 more source

Molecular Mechanism of the Urate-lowering Effects of Calcium Channel Blockers [PDF]

Hyperuricemia has recently been recognized as one of the risk factors for cardiovascular diseases. Some calcium channel blockers(CCBs), commonly used in the treatment of hypertension, have been reported to decrease serum urate level.
Tanaka-nakadate, Sawako, Ouchi, Motoshi, Fukuda, Hirotsugu, Hori, Takayuki, Jutabha, Promsuk, Onizawa, Nobuyuki, Otani, Naoyuki, Anzai, Naohiko, Oba, Toru, Tsuchiya, Go, Iseki, Tatou, Hayashi, Keitaro   +11 more
core   +1 more source

Concentration-dependent mode of interaction of angiotensin II receptor blockers with uric acid transporter. J Pharmacol Exp Ther 320

, 2007
Serum uric acid (SUA) is currently recognized as a risk factor for cardiovascular disease. It has been reported that an angiotensin II receptor blocker (ARB), losartan, decreases SUA level, whereas other ARBs, such as candesartan, have no lowering effect.
Ikumi Tamai, Masanobu Sato, Toshio Ogihara, □ S Takashi Iwanaga, Tomoji Maeda   +4 more
core  

<i>Brassica rapa</i> L. (Turnip) Ethanol Extract Alleviates Hyperuricemia by Modulating Purine Metabolism Enzymes and Renal Urate Transporters. [PDF]

Foods
Wang Y, Yang Y, Liu Y, Cheng D, Yao W, Yusuf A, Yang K.   +6 more
europepmc   +1 more source