Results 81 to 90 of about 2,667 (184)

A System for Discovering Novel Uricosurics Targeting Urate Transporter 1 Based on In Vitro and In Vivo Modeling

Pharmaceutics
Hyperuricemia has become a global burden with the increasing prevalence and risk of associated metabolic disorders and cardiovascular diseases. Uricosurics act as a vital urate-lowering therapy by promoting uric acid excretion via the kidneys.
Xuechen Li, Chufan Qi, Mengjie Shao, Yajun Yang, Yuying Wang, Jiang Li, Zhiyan Xiao, Fei Ye   +7 more
doaj   +1 more source

Antihyperuricemic effect of mangiferin aglycon derivative J99745 by inhibiting xanthine oxidase activity and urate transporter 1 expression in mice

Acta Pharmaceutica Sinica B, 2018
A mangiferin aglycon derivative J99745 has been identified as a potent xanthine oxidase (XOD) inhibitor by previous in vitro study. This study aimed to evaluate the hypouricemic effects of J99745 in experimental hyperuricemia mice, and explore the ...
Zhizhen Qin, Shoubao Wang, Yihuang Lin, Ying Zhao, Shengqian Yang, Junke Song, Tao Xie, Jinlong Tian, Song Wu, Guanhua Du   +9 more
doaj   +1 more source

Production Inhibition and Excretion Promotion of Urate by Fucoidan from Laminaria japonica in Adenine-Induced Hyperuricemic Mice

Marine Drugs, 2018
This work aims to explore the amelioration of fucoidan on adenine-induced hyperuricemia and hepatorental damage. Adenine-induced hyperuricemic mice were administered with fucoidan, allopurinol and vehicle control respectively to compare the effects of ...
Dayan Zhang, Huazhong Liu, Ping Luo, Yanqun Li   +3 more
doaj   +1 more source

Effect of acupuncture stimulation of “Shenshu” (BL23)-“Taixi” (KI3) on levels of serum uric acid and renal URAT1 and OAT1 protein expression in hyperuricemia rats

针刺研究, 2019
Objective To observe the effect of acupuncture at"Shenshu"(BL23)-"Taixi"(KI3)on the levels of serum uric acid(SUA)and expression of renal urate-anion transporter 1(URAT1)and organic anion transporter 1(OAT1)proteins in hyperuricemia(HUA)rats,so as to ...
LIU Xu-feng, CHEN Hong-yi, WANG Jing, YUN Su, HE Xiao-qian, TANG Xue-qing, SUI Ming-he   +6 more
doaj   +2 more sources

Gout management: Patent analytics and computational drug design explores URAT1 inhibitors landscape.

PLoS ONE
Gout, caused by hyperuricemia, has a detrimental impact on patients'quality of life. The urate transporter 1 (URAT1) stands out as a key therapeutic target. However, its clinical development remains uncertain.
Jiaxin Zhang, Liang Hong, Wenfei Xu, Xin Zhang, Huina Fu, Xinan Song, Jing Zhao   +6 more
doaj   +1 more source

Molecular determinants of selective and high-affinity binding of the scaffold protein PDZK1 to the urate transporter URAT1

The renal solute carrier URAT1 (SLC22A12) is essential for urate homeostasis, with loss-of-function linked to renal hypouricemia, nephrolithiasis and lower gout risk. URAT1 function depends on binding the multi-PDZ domain scaffold protein PDZK1 (NHERF3),
Hunte, Carola, Kern, Bianca A., Heinicke, Jonas Immanuel, Iaroslavtceva, Anastasiia K., Mymrikov, Evgeny V., Wirth, Christophe, Steck, Christoph, Mühlethaler, Tobias, Köttgen, Anna, Goll, Julian   +9 more
core   +1 more source

Ethanolic Extract from Limonia acidissima L. Fruit Attenuates Serum Uric Acid Level via URAT1 in Potassium Oxonate-Induced Hyperuricemic Rats

, 2023
A high prevalence of hyperuricemia among adult and older adult populations has intrigued the development of its therapy based on natural products.
Ikhsan Ikhsan, Rika Yusnaini, Nurdin Saidi, Rahmad Bahtiar, Rinaldi Idroes, Teti Arabia, Rosnani Nasution, Muhammad Iqhrammullah, Nasution, Rosnani, Bahtiar, Rahmad, Saidi, Nurdin, Ikhsan, Ikhsan, Iqhrammullah, Muhammad, Idroes, Rinaldi, Arabia, Teti, Yusnaini, Rika   +15 more
core   +1 more source

Solving the mysteries of urate transport: structural insights into GLUT9 and URAT1

Acta Materia Medica
Recent groundbreaking advances in the structural biology of the glucose transporter 9 (GLUT9) and urate transporter 1 (URAT1) have provided critical insights into the molecular mechanisms underlying urate recognition and transport.
Mei Wang, Shujing Xu, Xiaoyu Shi, Edeildo Ferreira da Silva-Júnior, Peng Zhan   +4 more
doaj   +1 more source

Impact of Viral Inflammation on the Expression of Renal Drug Transporters in Pregnant Rats

Pharmaceutics, 2019
Inflammation impacts the expression and function of drug transporters at term-gestation; however, the impact of inflammation on the expression of drug transporters at mid-gestation is largely unknown.
Navaz Karimian Pour, Eliza R. McColl, Micheline Piquette-Miller   +2 more
doaj   +1 more source

Efek Pemberian Ekstrak Etanol Kulit Melinjo (Gnetum gnemon) terhadap Ekspresi Gen URAT1 dan GLUT9 pada Tikus Wistar Model Hiperurisemia

, 2023
Hyperuricemia can occur because uric acid levels in the blood exceed normal limits. Where uric acid itself is the end product of purine metabolism in the body. Prolonged hyperuricemia will lead to gout, the consequences of the disease will be detrimental
Sofyan, Nurul Amalia
core   +1 more source