Results 61 to 70 of about 2,667 (184)

Stronger Uricosuric Effects of the Novel Selective URAT1 Inhibitor UR-1102 Lowered Plasma Urate in Tufted Capuchin Monkeys to a Greater Extent than Benzbromarone s [PDF]

, 2020
Urate-lowering therapy is indispensable for the treatment of gout, but available drugs do not control serum urate levels tightly enough. Although the uricosurics benzbromarone and probenecid inhibit a urate reabsorption transporter known as renal urate ...
Jumpei Kiyokawa, June Kyoung, Ki Hwan Lee, Sung Oh Ahn, Horiba, Mizuki Yamane, Yoshiki Tanaka, Jo Kim, Naoshi Kawabe, Byung Ho Kim, Toshito Nakagawa, Shuichi Ohtomo   +11 more
core  

Interaction of Human Renal Urate Transporter URAT1 and X-Ray Contrast Agent Iodipamide [PDF]

降圧薬などいくつかの薬剤は本来の薬理作用とは別に尿酸降下作用を持つものがあり,水溶性ヨード系造影剤もその一つでiodipamideやdiatrizoateでの尿酸排泄亢進が報告されていた.長らく不明のままであった腎尿酸輸送機構の分子実体は2002年の腎尿細管尿酸トランスポーターURAT1(Urate Transporter 1)の分子同定によりその理解が飛躍的に進んだ.本研究ではURAT1と水溶性造影剤のiodipamideおよびdiatrizoateの相互作用を検討することで ...
大谷, 直由, 花田, 健治, 森田, 亜州華, アベ, トクロウ, ハナダ, ケンジ, Otani, Naoyuki, 林, 啓太朗, 岡本, 和久, 大内, 基司, オカモト, カズヒサ, オオタニ, ナオユキ, Okamoto, Kazuhisa, Hanada, Kenji, 阿部, 篤朗, オオウチ, モトシ, アンザイ, ナオヒコ, ハヤシ, ケイタロウ, 安西, 尚彦, モリタ, アスカ, Morita, Asuka, Ouchi, Motoshi, ジユタバ, プロムスク, Jutabha, Promsuk, Abe, Tokuro, Anzai, Naohiko, Hayashi, Keitaro   +25 more
core   +1 more source

Nucleotide Metabolism in Health and Disease

MedComm, Volume 7, Issue 8, August 2026.
Nucleotide metabolism, including de novo synthesis, salvage pathways, and catabolism, when dysregulated contributes to cancer, immune disorders, metabolic and urological diseases, and radiation injury. Metabolites such as adenosine, cGAMP, NAD, and cAMP and enzymes like RNR are promising therapeutic targets and biomarkers.
Xiaoying Zhao, Yiyu Zeng, Yike Xu, Shu Rao, Mouna Khouchani, Hassna Soummane, Jingyi Li, Rui Liu   +7 more
wiley   +1 more source

A Possible Therapeutic Application of the Selective Inhibitor of Urate Transporter 1, Dotinurad, for Metabolic Syndrome, Chronic Kidney Disease, and Cardiovascular Disease

Cells
The reabsorption of uric acid (UA) is mainly mediated by urate transporter 1 (URAT1) and glucose transporter 9 (GLUT9) in the kidneys. Dotinurad inhibits URAT1 but does not inhibit other UA transporters, such as GLUT9, ATP-binding cassette transporter G2
Hidekatsu Yanai, Hiroki Adachi, Mariko Hakoshima, Sakura Iida, Hisayuki Katsuyama   +4 more
doaj   +1 more source

Modulation of Urate Transport by Drugs

Pharmaceutics, 2021
Background: Serum urate (SU) levels in primates are extraordinarily high among mammals. Urate is a Janus-faced molecule that acts physiologically as a protective antioxidant but provokes inflammation and gout when it precipitates at high concentrations ...
Péter Tátrai, Franciska Erdő, Gabriella Dörnyei, Péter Krajcsi   +3 more
doaj   +1 more source

Exercise-induced changes in renal URAT1 activity and expression in rats

Renal Failure, 2010
During exercise, the plasma urate levels and urinary excretion increase due to the enhanced purine degradation in skeletal muscle. Although urate transporter-1 (URAT1) is the main transporter responsible for the reabsorption of filtered urate, potential changes in its activity and expression during exercise have not been studied yet.
Selma, Cirrik, Bahriye Uğur, Yavuzer, Gülsen, Oner   +2 more
openaire   +2 more sources

Serum Uric Acid Changes in Relation to Nighttime Blood Pressure Dipping Status in Patients on Antihypertensive Therapy

The Journal of Clinical Hypertension, Volume 28, Issue 7, July 2026.
ABSTRACT We performed a post hoc exploratory secondary analysis to investigate whether baseline circadian blood pressure (BP) pattern was associated with changes in serum uric acid (SUA) during 8‐week antihypertensive therapy. Of the 494 hypertensive patients who received amlodipine (5–10 mg) or nifedipine GITS (30–60 mg) for 8 weeks, 369 patients with
Di Zhang, Qi‐Fang Huang, Yan Li, Ji‐Guang Wang   +3 more
wiley   +1 more source

Response to Allopurinol and Febuxostat According to the Fractional Excretion of Urate in Men With Gout

Arthritis Care &Research, Volume 78, Issue 6, Page 781-787, June 2026.
Objective Body mass index (BMI), glomerular filtration rate (GFR), and pretreatment urate levels have been reported to influence the urate‐lowering response to allopurinol. We investigated whether the fractional excretion of uric acid (FEUA) also modulates this response and relates to oxypurinol concentrations.
Pascal Richette, Anouk Walter‐Petrich, Quang Dinh Nguyen, Matthieu Resche‐Rigon, Quang Huy Dinh Nguyen, Minh Duc Do, Thao Phuong Mai, Tuan Duc Nguyen, Fernando Perez‐Ruiz, Emmanuel Letavernier, Tristan Pascart, Augustin Latourte, Hang Korng Ea, Thomas Bardin   +13 more
wiley   +1 more source

Modified Chuanhu anti-gout mixture, a traditional Chinese medicine, protects against potassium oxonate-induced hyperuricemia and renal dysfunction in mice

Journal of International Medical Research, 2019
Objective Acute gout is a painful, inflammatory arthritis that features a rapidly escalating inflammatory response resulting from the formation of monosodium urate crystals in the affected joint space. Previously, we found that Chuanhu anti-gout mixture (
Wenjun You, Jie Wang, Yaowu Zou, Kui Che, Xu Hou, Honghua Fei, Yangang Wang   +6 more
doaj   +1 more source

Absence of SLC22A12/URAT1 Gene Mutations in Patients with Primary Gout [PDF]

The Journal of Rheumatology, 2012
To the Editor: In most patients with primary gout, hyperuricemia has been related to a decreased urinary uric acid excretion, but the specific gene abnormalities that may cause an impaired tubular transport of urate are unknown. The first urate transporter described was SLC22A12/URAT1 1.
Rosa J, Torres, Eugenio, De Miguel, Rebeca, Bailen, Juan G, Puig   +3 more
openaire   +2 more sources