Results 71 to 80 of about 2,667 (184)

Combined Anserine/Carnosine Exerts Anti‐Hyperuricemic, Nephroprotective, and Gut Microbiota‐Modulating Effects in Hyperuricemia Mice

Food Bioengineering, Volume 5, Issue 2, Page 194-208, June 2026.
Mixed carnosine and anserine significantly reduce serum uric acid, protect the kidneys, and modulate gut microbiota, demonstrating potent therapeutic potential against hyperuricemia. ABSTRACT The anti‐hyperuricemic, nephroprotective, and gut microbiota modulation effects of mixed carnosine and anserine (MAC) with the fixed ratio of 10:1 were evaluated ...
Jingjing Huang, Zheng Dang, Yuzhi Zhang, Haisheng Lin, Lei Du, Jie Zhang, Li Zhao, William T. H. Chang, Xiang‐Ru Kong, Wei‐Ting Tseng, Jingli Xie   +10 more
wiley   +1 more source

Antihyperuricemic Effect of Hawthorn Flavonoid Vitexin: LC–MS Analysis, Network Pharmacology, and In Vivo Verification of Molecular Mechanisms

Food Science &Nutrition, Volume 14, Issue 6, June 2026.
UPLC‐MS/MS analysis of hawthorn flavonoids combined with network pharmacology, molecular docking, and molecular dynamics studies predicted vitexin as a key compound acting on the PPARγ/ABCG2 pathway. In a hyperuricemic mouse model, vitexin effectively lowered serum uric acid by enhancing renal and intestinal urate excretion, inhibiting urate production,
Shu‐Yu Wu, Kai‐Wen Kang, Dan‐Yu Huang, Shu‐Ying Li, Hao Zheng, Ri‐Hui Wu, Hui‐Qing Lv, Wan‐Bin Song, Jing Chen, Cheng‐Ping Wen, Li‐She Gan, Xiao Yuan   +11 more
wiley   +1 more source

Immunoreactivity of urate transporters, GLUT9 and URAT1, is located in epithelial cells of the choroid plexus of human brains [PDF]

, 2020
香川大学Kagawa University博士（医学）Abstract It has been suggested that urate plays a protective role in neurons, while hyperuricemia is correlated with atherosclerosis and cardiovascular disease.
Uemura, Naoya, 植村, 直哉, ウエムラ, ナオヤ   +2 more
core   +1 more source

Uric Acid in Metabolic Dysfunction‐Associated Steatotic Liver Disease

Portal Hypertension &Cirrhosis, Volume 5, Issue 2, Page 189-206, June 2026.
MASLD is the most prevalent chronic liver disease worldwide, yet effective pharmacological treatments remain limited. Hyperuricemia is now recognized as a key driver of hepatic steatosis, inflammation, and fibrosis, with elevated serum uric acid levels independently predicting hepatocellular carcinoma and liver‐related mortality.
Rong Wang, Zhenyu Liu, Jun Lin, Weijing Zhang, Xianzhi Liu, Tong Zhang   +5 more
wiley   +1 more source

PFOS increases cellular uric acid content and the abundance of URAT1 and GLUT9 in HK-2 cells

Ecotoxicology and Environmental Safety
Perfluorooctane sulfonate (PFOS) is a persistent environmental pollutant associated with hyperuricemia. How PFOS affects urate-related responses in human proximal-tubule cells remains incompletely understood.
Haotian Cui, Chen Li, Wei Zhang, Weipeng Yang, Ruihan Ge, Xinmin Wang, Le Zhang   +6 more
doaj   +1 more source

Chicory (Cichorium intybus L.) inhibits renal reabsorption by regulating expression of urate transporters in fructose-induced hyperuricemia

Journal of Traditional Chinese Medical Sciences, 2019
Objective: Hyperuricemia is an excess of urate in blood. The kidneys play important parts in urate excretion, which involves handling reabsorption and secretion.
Yu Wang, Zhijian Lin, Bing Zhang, Xiao Wang, Mengzhen Chu   +4 more
doaj   +1 more source

Renal Reabsorptive Transport of Uric Acid Precursor Xanthine by URAT1 and GLUT9

Biological and Pharmaceutical Bulletin, 2020
Xanthine and hypoxanthine are intermediate metabolites of uric acid and a source of reactive oxidative species (ROS) by xanthine oxidoreductase (XOR), suggesting that facilitating their elimination is beneficial. Since they are reabsorbed in renal proximal tubules, we investigated their reabsorption mechanism by focusing on the renal uric acid ...
Arakawa, Hiroshi, Amezawa, Natsumi, Kawakatsu, Yu, Tamai, Ikumi   +3 more
openaire   +3 more sources

Benzofuran‐Based Uricosuric Agents: History, Roles, and Challenges

ChemistrySelect, Volume 11, Issue 24, 25 June 2026.
Benzofuran‐based uricosuric agents represent a privileged medicinal chemistry scaffold for gout therapy. Structural optimization of benzbromarone‐related derivatives has improved hURAT1 inhibitory potency, metabolic stability, and urate‐lowering efficacy, while reducing hepatotoxic liability.
Raed M. Al‐Zoubi, Basma Hanbali, Mai Elaarag, Zainab Fares, Enas A. Al‐Hurani, Sally R. Al‐Zoubi, Mohanad Shkoor, Abdelali Agouni   +7 more
wiley   +1 more source

Efficacy of URAT1 inhibition.

, 2014
(A) Effects of Losartan and Probenecid on UA-induced apoptosis. HK-2 were treated with 1–10 µM Losartan or 20 µM Probenecid and 12 mg/dl UA for 48 hours. Cells were stained by anti-cleaved caspase 3 antibody and examined under microscope. Apoptotic cells
Roberto Pontremoli (675396), Daniela Verzola (675393), Elena Ratto (675394), Barbara Villaggio (11571), Francesca Viazzi (675398), Giacomo Garibotto (675397), Emanuele Luigi Parodi (675395)   +6 more
core   +1 more source

Interaction and Joint Effects of Inflammation and Triglyceride–Glucose (TyG) Index on Hyperuricemia Risk and the Mediating Role of TyG: A Cross‐Sectional Study

Endocrinology, Diabetes &Metabolism, Volume 9, Issue 3, May 2026.
Among 5307 southern Chinese adults, higher TyG index and mINFLA score were associated with increased HUA risk and serum UA levels (p trend < 0.001). A significant interaction was observed between these two indicators. Notably, the TyG index mediated 15.4% of the mINFLA‐HUA association and 14.5% of the mINFLA‐UA association.
Xueran Huang, Pengfei Chen, Yongfen Gao, Zengnan Mo, Haiying Zhang, Rui Lin   +5 more
wiley   +1 more source