Results 51 to 60 of about 2,667 (184)
Medicine Bulletin, Volume 2, Issue 4, Page 459-475, September 2026.Allisartan ranked best for serum urate reduction and showed favourable blood pressure control, whereas losartan also performed well overall. These rankings may inform ARB selection but should be interpreted cautiously because of inconsistency, heterogeneity and sparse direct evidence.
Xuanyao Li +5 more
wiley +1 more source
Metabolic Acidosis Alters Expression of Slc22 Transporters in Mouse Kidney
Kidney & Blood Pressure Research, 2020 Introduction: The kidneys play a central role in eliminating metabolic waste products and drugs through transporter-mediated excretion along the proximal tubule.
Janine Gottier Nwafor +4 more
doaj +1 more source
Farnesoid X receptor prevents hyperuricemia via activating ATP‐binding cassette subfamily G member 2
Rheumatology &Autoimmunity, Volume 6, Issue 3, Page 169-176, September 2026.Farnesoid X receptor (FXR) activation reduces serum uric acid levels by upregulating the intestinal urate transporter ATP‐binding cassette subfamily G member 2 (ABCG2). These findings uncover a novel metabolic pathway for urate excretion and suggest that FXR agonists (e.g., obeticholic acid), represent a promising therapeutic strategy for the treatment
Rui Li +5 more
wiley +1 more source
Diabetes, Obesity and Metabolism, Volume 28, Issue 9, Page 8230-8241, September 2026.ABSTRACT Aim Sodium‐glucose cotransporter‐2 inhibitors (SGLT2i) are known to reduce serum urate levels, yet their specific impact on gout incidence in the Korean population remains underexplored. We investigated the association between SGLT2i use and incident gout using real‐world data and Mendelian randomisation (MR) analysis. Materials and Methods We
Hong Sang Choi +7 more
wiley +1 more source
Lactobacillus acidophilus Fermented Dandelion Improves Hyperuricemia and Regulates Gut Microbiota
Fermentation, 2023 Foodborne prevention and treatment of hyperuricemia (HUA) has received widespread attention. Lactic acid bacteria (LAB) can improve intestinal function, while traditional medicine dandelion has the functions of detoxification and detumescence.
Qianwen Ma +9 more
doaj +1 more source
, 2017 Hyperuricemia (HUA) is related to diabetes. Uric acid-induced inflammation and oxidative stress are risk factors for diabetes and its complications. Human urate transporter 1 (URAT1) regulates the renal tubular reabsorption of uric acid.
Jinzhi Fang +12 more
core +1 more source
Clinical and Functional Characterization of URAT1 Variants [PDF]
Idiopathic renal hypouricaemia is an inherited form of hypouricaemia, associated with abnormal renal handling of uric acid. There is excessive urinary wasting of uric acid resulting in hypouricaemia.
Tasic V +8 more
core +4 more sources
Functional cooperation of URAT1 (SLC22A12) and URATv1 (SLC2A9) in renal reabsorption of urate [PDF]
Nephrology Dialysis Transplantation, 2013 Serum urate (SUA) level is affected by alteration in urinary reabsorption caused by clinically important drugs; however, there are no experimental models suitable to assess their effect on renal reabsorption. We, therefore, aimed to establish an experimental system co-expressing the urate transporters URAT1 (SLC22A12) and URATv1 (SLC2A9) (designated ...
Takeo, Nakanishi +4 more
openaire +2 more sources
Food Science &Nutrition, Volume 14, Issue 8, August 2026.In 5773 adults followed for ~5 years, higher EAT–Lancet diet adherence was consistently associated with lower incident hyperuricemia and lower serum uric acid. Associations were observed across three EAT–Lancet scoring approaches and persisted after adjustment for established dietary‐quality indices. Baseline HOMA‐IR may partly mediate this association,
Farzam Kamrani +7 more
wiley +1 more source
Association Between TyG‐WC and Gout in American Adults: A Cross‐Sectional Study of NHANES 2003–2018
Health Science Reports, Volume 9, Issue 8, August 2026.ABSTRACT Background and Aims The triglyceride‐glucose (TyG) index is widely used as a surrogate marker of insulin resistance. Indices that combine TyG with anthropometric measures may better reflect metabolic dysfunction and central adiposity. However, evidence regarding the association between TyG‐waist circumference (TyG‐WC) and gout among U.S ...
Shenlong Yi +7 more
wiley +1 more source